Contains      

UniProtKB-Q16620

Protein BDNF/NT-3 growth factors receptor
Gene NTRK2
Status Reviewed
Source Breast Cancer cell lines; Breast cancer cell lines; Breast cancer xenografts; Breast tumor; Cerebrospinal fluid; Colorectal tumor; Liver; Ovarian tumor; Pancreatic islets; Plasma; Prostate; Prostate tumor; Serum; Urine
Years 2005-2015

Glycosites

Site Identified Peptides Year(Publication ID)
67 LEPNSVDPEnITEIFIANQK 2005( 81); 2013(45); 2015(unpublished);2015(unpublished);2007(unpublished);2007;2007;
95 nLTIVDSGLK 2012(48); 2013(45); 2014(33); 2015(unpublished);2015(unpublished);2007(unpublished);2007(unpublished);2007;2007;
95 AYVGIRnITIVDS 2013(37);
121 HInFTR 2012(48);
121 NSNLQHInFTR 2005( 81); 2007(42); 2013(13); 2014(33); 2014(unpublished);2015(unpublished);2015(unpublished);2015(unpublished);2007;2007;2007;2007;
121 SNIQHInFTRNKI 2013(37);
178 SSPDTQDLYCLnESSK 2012(48); 2015(unpublished);2015(unpublished);2015;2007;2007;
205 PnLTVEEGK 2012(48);
205 APnLTVEEGK 2012(48);
205 LAAPnLTVEEGK 2012(48);
205 AAPnLTVEEGKSITL 2014(33);
241 MnETSHTQGSLR 2012(48);
241 HMnETSHTQGSLR 2012(48); 2013(45); 2014(33); 2015(10);
241 IVSKHMnETSHTQ 2013(37);
254 ITnISSDDSGK 2005( 81); 2012(48); 2013(45); 2014(13); 2014(14); 2014(22); 2014(33); 2015(10); 2015(unpublished);2015(unpublished);2015;2015;2015;2007;2007;
254 GSIRITnISSDDS 2013(37);
325 FYNGAILnESKY 2014(33);
325 PALQWFYNGAILnESK 2012(48);
325 GNPKPALQWFYNGAILnESK 2012(48); 2013(45);
338 IHVTnHTE 2012(48); 2014(33);
338 IHVTnHTEYH 2012(48);
338 IHVTnHTEYHGCLQ 2012(48);
486 FGMKGPASVISNDDDSASPLHHISnGSNTPSSSEGGPDAVIIGMTK 2015(unpublished);

Sequence

1112131415161718191
MSSWIRWHGPAMARLWGFCWLVVGFWRAAFACPTSCKCSASRIWCSDPSPGIVAFPRLEPNSVDPENITEIFIANQKRLEIINEDDVEAYVGLRNLTIVD
101111121131141151161171181191
SGLKFVAHKAFLKNSNLQHINFTRNKLTSLSRKHFRHLDLSELILVGNPFTCSCDIMWIKTLQEAKSSPDTQDLYCLNESSKNIPLANLQIPNCGLPSAN
201211221231241251261271281291
LAAPNLTVEEGKSITLSCSVAGDPVPNMYWDVGNLVSKHMNETSHTQGSLRITNISSDDSGKQISCVAENLVGEDQDSVNLTVHFAPTITFLESPTSDHH
301311321331341351361371381391
WCIPFTVKGNPKPALQWFYNGAILNESKYICTKIHVTNHTEYHGCLQLDNPTHMNNGDYTLIAKNEYGKDEKQISAHFMGWPGIDDGANPNYPDVIYEDY
401411421431441451461471481491
GTAANDIGDTTNRSNEIPSTDVTDKTGREHLSVYAVVVIASVVGFCLLVMLFLLKLARHSKFGMKGPASVISNDDDSASPLHHISNGSNTPSSSEGGPDA
501511521531541551561571581591
VIIGMTKIPVIENPQYFGITNSQLKPDTFVQHIKRHNIVLKRELGEGAFGKVFLAECYNLCPEQDKILVAVKTLKDASDNARKDFHREAELLTNLQHEHI
601611621631641651661671681691
VKFYGVCVEGDPLIMVFEYMKHGDLNKFLRAHGPDAVLMAEGNPPTELTQSQMLHIAQQIAAGMVYLASQHFVHRDLATRNCLVGENLLVKIGDFGMSRD
701711721731741751761771781791
VYSTDYYRVGGHTMLPIRWMPPESIMYRKFTTESDVWSLGVVLWEIFTYGKQPWYQLSNNEVIECITQGRVLQRPRTCPQEVYELMLGCWQREPHMRKNI
801811821
KGIHTLLQNLAKASPVYLDILG

Reference

ID Publication
10Tan ZJ, Yin HD, Nie S, Lin ZX, Zhu JH, Ruffin MT, Anderson MA, Simone DM, Lubman DM: Large-Scale Identification of Core-Fucosylated Glycopeptide Sites in Pancreatic Cancer Serum Using Mass Spectrometry. Journal of Proteome Research 2015, 14:1968-1978.
13Yang W, Laeyendecker O, Wendel SK, Zhang B, Sun S, Zhou J-Y, Ao M, Moore RD, Jackson JB, Zhang H: Glycoproteomic Study Reveals Altered Plasma Proteins Associated with HIV Elite Suppressors. Theranostics 2014, 4:1153.
14Liu Y, Chen J, Sethi A, Li QK, Chen L, Collins B, Gillet LC, Wollscheid B, Zhang H, Aebersold R: Glycoproteomic analysis of prostate cancer tissues by SWATH mass spectrometry discovers N-acylethanolamine acid amidase and protein tyrosine kinase 7 as signatures for tumor aggressiveness. Molecular & Cellular Proteomics 2014, 13:1753-1768.
22Nicastri A, Gaspari M, Sacco R, Elia L, Gabriele C, Romano R, Rizzuto A, Cuda G: N-Glycoprotein Analysis Discovers New Up-Regulated Glycoproteins in Colorectal Cancer Tissue. Journal of Proteome Research 2014, 13:4932-4941.
33Zhu J, Sun Z, Cheng K, Chen R, Ye M, Xu B, Sun D, Wang L, Liu J, Wang F, Zou H: Comprehensive Mapping of Protein N-Glycosylation in Human Liver by Combining Hydrophilic Interaction Chromatography and Hydrazide Chemistry. Journal of Proteome Research 2014, 13:1713-1721.
37Boersema PJ, Geiger T, Wisniewski JR, Mann M: Quantification of the N-glycosylated Secretome by Super-SILAC During Breast Cancer Progression and in Human Blood Samples. Molecular & Cellular Proteomics 2013, 12:158-171.
42Ma C, Zhao X, Han H, Tong W, Zhang Q, Qin P, Chang C, Peng B, Ying W, Qian X: N-linked glycoproteome profiling of human serum using tandem enrichment and multiple fraction concatenation. Electrophoresis 2013, 34:2440-2450.
45Zhou H, Froehlich JW, Briscoe AC, Lee RS: The GlycoFilter: A Simple and Comprehensive Sample Preparation Platform for Proteomics, N-Glycomics and Glycosylation Site Assignment. Molecular & Cellular Proteomics 2013, 12:2981-2991.
48Danzer C, Eckhardt K, Schmidt A, Fankhauser N, Ribrioux S, Wollscheid B, Mueller L, Schiess R, Zuellig R, Lehmann R, et al: Comprehensive Description of the N-Glycoproteome of Mouse Pancreatic beta-Cells and Human Islets. Journal of Proteome Research 2012, 11:1598-1608.