Detail


Protein	FRAS1-related extracellular matrix protein 1
Gene	FREM1
Status	Reviewed
Source	HepG2 cell line (Liver); Prostate; Prostate tumor; Urine
Years	2007-2014

Site	Identified Peptides	Year(Publication ID)
374	DLSDMQIAYQPPnSSHSER	2014(14);
1683	HGHLEnTTTGEFIHEK	2007(38); 2013(unpublished);2007(unpublished);2007;

Sequence

1	11	21	31	41	51	61	71	81	91
MNSLSWGAAN	AVLLLLLLAW	ASPTFISINR	GVRVMKGHSA	FLSGDDLKFA	IPKEKDACKV	EVVMNEPITQ	RVGKLTPQVF	DCHFLPNEVK	YVHNGCPILD
101	111	121	131	141	151	161	171	181	191
EDTVKLRLYR	FTERDTFIET	FILWVYLLEP	DCNIIHMSNN	VLEVPEFNGL	SQAIDKNLLR	FDYDRMASLE	CTVSLDTART	RLPAHGQMVL	GEPRPEEPRG
201	211	221	231	241	251	261	271	281	291
DQPHSFFPES	QLRAKLKCPG	GSCTPGLKKI	GSLKVSCEEF	LLMGLRYQHL	DPPSPNIDYI	SIQLDLTDTR	SKIVYKSESA	WLPVYIRAGI	PNQIPKAAFM
301	311	321	331	341	351	361	371	381	391
AVFILEVDQF	ILTSLTTSVL	DCEEDETPKP	LLVFNITKAP	LQGYVTHLLD	HTRPISSFTW	KDLSDMQIAY	QPPNSSHSER	RHDEVELEVY	DFFFERSAPM
401	411	421	431	441	451	461	471	481	491
TVHISIRTAD	TNAPRVSWNT	GLSLLEGQSR	AITWEQFQVV	DNDDIGAVRL	VTVGGLQHGW	LTLRGGKGFL	FTVADLQAGV	VRYHHDDSDS	TKDFVVFRIF
501	511	521	531	541	551	561	571	581	591
DGHHSIRHKF	PINVLPKDDS	PPFLITNVVI	ELEEGQTILI	QGSMLRASDV	DASDDYIFFN	ITKPPQAGEI	MKKPGPGLIG	YPVHGFLQRD	LFNGIIYYRH
601	611	621	631	641	651	661	671	681	691
FGGEIFEDSF	QFVLWDSHEP	PNLSVPQVAT	IHITPVDDQL	PKEAPGVSRH	LVVKETEVAY	ITKKQLHFID	SESYDRELVY	TITTPPFFSF	SHRHLDAGKL
701	711	721	731	741	751	761	771	781	791
FMVDSIPKVV	KNPTALELRS	FTQHAVNYMK	VAYMPPMQDI	GPHCRDVQFT	FSVSNQHGGT	LHGICFNITI	LPVDNQVPEA	FTNPLKVTEG	GQSIISTEHI
801	811	821	831	841	851	861	871	881	891
LISDADTKLD	NIDLSLRELP	LHGRVELNGF	PLNSGGTFSW	GDLHTLKVRY	QHDGTEVLQD	DLLLEVTDGT	NSAEFVLHVE	VFPVNDEPPV	LKADLMPVMN
901	911	921	931	941	951	961	971	981	991
CSEGGEVVIT	SEYIFATDVD	SDNLKLMFVI	AREPQHGVVR	RAGVTVDQFS	QRDVISEAVT	YKHTGGEIGL	MPCFDTITLV	VSDGEAGPFV	NGCCYNGPNP
1001	1011	1021	1031	1041	1051	1061	1071	1081	1091
SVPLHASFPV	YDLNITVYPV	DNQPPSIAIG	PVFVVDEGCS	TALTVNHLSA	TDPDTAADDL	EFVLVSPPQF	GYLENILPSV	GFEKSNIGIS	IDSFQWKDMN
1101	1111	1121	1131	1141	1151	1161	1171	1181	1191
AFHINYVQSR	HLRIEPTADQ	FTVYVTDGKH	HSLEIPFSII	INPTNDEAPD	FVVQNITVCE	GQMKELDSSI	ISAVDLDIPQ	DALLFSITQK	PRHGLLIDRG
1201	1211	1221	1231	1241	1251	1261	1271	1281	1291
FSKDFSENKQ	PANPHQKHAP	VHSFSMELLK	TGMRLTYMHD	DSESLADDFT	IQLSDGKHKI	LKTISVEVIP	VNDEKPMLSK	KAEIAMNMGE	TRIISSAILS
1301	1311	1321	1331	1341	1351	1361	1371	1381	1391
AIDEDSPREK	IYYVFERLPQ	NGQLQLKIGR	DWVPLSPGMK	CTQEEVDLNL	LRYTHTGAMD	SQNQDSFTFY	LWDGNNRSPA	LDCQITIKDM	EKGDIVILTK
1401	1411	1421	1431	1441	1451	1461	1471	1481	1491
PLVVSKGDRG	FLTTTTLLAV	DGTDKPEELL	YVITSPPRYG	QIEYVHYPGV	PITNFSQMDV	VGQTVCYVHK	SKVTVSSDRF	RFIISNGLRT	EHGVFEITLE
1501	1511	1521	1531	1541	1551	1561	1571	1581	1591
TVDRALPVVT	RNKGLRLAQG	AVGLLSPDLL	QLTDPDTPAE	NLTFLLVQLP	QHGQLYLWGT	GLLQHNFTQQ	DVDSKNVAYR	HSGGDSQTDC	FTFMATDGTN
1601	1611	1621	1631	1641	1651	1661	1671	1681	1691
QGFIVNGRVW	EEPVLFTIQV	DQLDKTAPRI	TLLHSPSQVG	LLKNGCYGIY	ITSRVLKASD	PDTEDDQIIF	KILQGPKHGH	LENTTTGEFI	HEKFSQKDLN
1701	1711	1721	1731	1741	1751	1761	1771	1781	1791
SKTILYIINP	SLEVNSDTVE	FQIMDPTGNS	ATPQILELKW	SHIEWSQTEY	EVCENVGLLP	LEIIRRGYSM	DSAFVGIKVN	QVSAAVGKDF	TVIPSKLIQF
1801	1811	1821	1831	1841	1851	1861	1871	1881	1891
DPGMSTKMWN	IAITYDGLEE	DDEVFEVILN	SPVNAVLGTK	TKAAVKILDS	KGGQCHPSYS	SNQSKHSTWE	KGIWHLLPPG	SSSSTTSGSF	HLERRPLPSS
1901	1911	1921	1931	1941	1951	1961	1971	1981	1991
MQLAVIRGDT	LRGFDSTDLS	QRKLRTRGNG	KTVRPSSVYR	NGTDIIYNYH	GIVSLKLEDD	SFPTHKRKAK	VSIISQPQKT	IKVAELPQAD	KVESTTDSHF
2001	2011	2021	2031	2041	2051	2061	2071	2081	2091
PRQDQLPSFP	KNCTLELKGL	FHFEEGIQKL	YQCNGIAWKA	WSPQTKDVED	KSCPAGWHQH	SGYCHILITE	QKGTWNAAAQ	ACREQYLGNL	VTVFSRQHMR
2101	2111	2121	2131	2141	2151	2161	2171
WLWDIGGRKS	FWIGLNDQVH	AGHWEWIGGE	PVAFTNGRRG	PSQRSKLGKS	CVLVQRQGKW	QTKDCRRAKP	HNYVCSRKL

UniProtKB-Q5H8C1

Glycosites

Sequence

Reference

ID	Publication
14	Liu Y, Chen J, Sethi A, Li QK, Chen L, Collins B, Gillet LC, Wollscheid B, Zhang H, Aebersold R: Glycoproteomic analysis of prostate cancer tissues by SWATH mass spectrometry discovers N-acylethanolamine acid amidase and protein tyrosine kinase 7 as signatures for tumor aggressiveness. Molecular & Cellular Proteomics 2014, 13:1753-1768.
38	Kaji H, Ocho M, Togayachi A, Kuno A, Sogabe M, Ohkura T, Nozaki H, Angata T, Chiba Y, Ozaki H, et al: Glycoproteomic Discovery of Serological Biomarker Candidates for HCV/HBV Infection-Associated Liver Fibrosis and Hepatocellular Carcinoma. Journal of Proteome Research 2013, 12:2630-2640.