Detail

Contains

UniProtKB-Q5HYA8


Protein	Meckelin
Gene	TMEM67
Status	Reviewed
Source	Breast cancer xenografts; DLBCL cell lines (Diffuse large B-cell lymphoma); OVCAR-3 cell line (Ovarian cancer); Pancreatic islets
Years	2012-2015

Glycosites

Site	Identified Peptides	Year(Publication ID)
141	DInGTLLSQATCELCDGNENSFMVVNALGDR	2015(1);
179	CEPTFVnTSR	2012(48); 2014(16); 2015(unpublished);

Sequence

1	11	21	31	41	51	61	71	81	91
MATRGGAGVA	MAVWSLLSAR	AVTAFLLLFL	PRFLQAQTFS	FPFQQPEKCD	NNQYFDISAL	SCVPCGANQR	QDARGTSCVC	LPGFQMISNN	GGPAIICKKC
101	111	121	131	141	151	161	171	181	191
PENMKGVTED	GWNCISCPSD	LTAEGKCHCP	IGHILVERDI	NGTLLSQATC	ELCDGNENSF	MVVNALGDRC	VRCEPTFVNT	SRSCACSEPN	ILTGGLCFSS
201	211	221	231	241	251	261	271	281	291
TGNFPLRRIS	AARYGEVGMS	LTSEWFAKYL	QSSAAACWVY	ANLTSCQALG	NMCVMNMNSY	DFATFDACGL	FQFIFENTAG	LSTVHSISFW	RQNLPWLFYG
301	311	321	331	341	351	361	371	381	391
DQLGLAPQVL	SSTSLPTNFS	FKGENQNTKL	KFVAASYDIR	GNFLKWQTLE	GGVLQLCPDT	ETRLNAAYSF	GTTYQQNCEI	PISKILIDFP	TPIFYDVYLE
401	411	421	431	441	451	461	471	481	491
YTDENQHQYI	LAVPVLNLNL	QHNKIFVNQD	SNSGKWLLTR	RIFLVDAVSG	RENDLGTQPR	VIRVATQISL	SVHLVPNTIN	GNIYPPLITI	AYSDIDIKDA
501	511	521	531	541	551	561	571	581	591
NSQSVKVSFS	VTYEMDHGEA	HVQTDIALGV	LGGLAVLASL	LKTAGWKRRI	GSPMIDLQTV	VKFLVYYAGD	LANVFFIITV	GTGLYWLIFF	KAQKSVSVLL
601	611	621	631	641	651	661	671	681	691
PMPIQEERFV	TYVGCAFALK	ALQFLHKLIS	QITIDVFFID	WERPKGKVLK	AVEGEGGVRS	ATVPVSIWRT	YFVANEWNEI	QTVRKINSLF	QVLTVLFFLE
701	711	721	731	741	751	761	771	781	791
VVGFKNLALM	DSSSSLSRNP	PSYIAPYSCI	LRYAVSAALW	LAIGIIQVVF	FAVFYERFIE	DKIRQFVDLC	SMSNISVFLL	SHKCFGYYIH	GRSVHGHADT
801	811	821	831	841	851	861	871	881	891
NMEEMNMNLK	REAENLCSQR	GLVPNTDGQT	FEIAISNQMR	QHYDRIHETL	IRKNGPARLL	SSSASTFEQS	IKAYHMMNKF	LGSFIDHVHK	EMDYFIKDKL
901	911	921	931	941	951	961	971	981	991
LLERILGMEF	MEPMEKSIFY	NDEGYSFSSV	LYYGNEATLL	IFDLLFFCVV	DLACQNFILA	SFLTYLQQEI	FRYIRNTVGQ	KNLASKTLVD	QRFLI

Reference

ID	Publication
1	Sun S, Shah P, Eshghi ST, Yang W, Trikannad N, Yang S, Chen L, Aiyetan P, Hoti N, Zhang Z, et al: Comprehensive analysis of protein glycosylation by solid-phase extraction of N-linked glycans and glycosite-containing peptides. Nat Biotech 2015, advance online publication.
16	Deeb SJ, Cox J, Schmidt-Supprian M, Mann M: N-linked Glycosylation Enrichment for In-depth Cell Surface Proteomics of Diffuse Large B-cell Lymphoma Subtypes. Molecular & Cellular Proteomics 2014, 13:240-251.
48	Danzer C, Eckhardt K, Schmidt A, Fankhauser N, Ribrioux S, Wollscheid B, Mueller L, Schiess R, Zuellig R, Lehmann R, et al: Comprehensive Description of the N-Glycoproteome of Mouse Pancreatic beta-Cells and Human Islets. Journal of Proteome Research 2012, 11:1598-1608.