Protein | Endoplasmic reticulum aminopeptidase 2 |
Gene | ERAP2 |
Status | Reviewed |
Source | Breast Cancer cell lines; Colorectal tumor; DLBCL cell lines (Diffuse large B-cell lymphoma); HCC cell lines (Liver); HCC cell lines (Liver)Jurkat T cell line; Jurkat T cell line; LNCap/PC3 cell lines (Prostate cancer); Liver; Liver tumor (HCC); OVCAR-3 cell line (Ovarian cancer); Ovarian tumor; Pancreatic islets; Plasma; Platelet; Prostate; Prostate tumor; SKOV-3 cell line (Ovarian cancer); SW1990 cell line (Pancreatic cancer); Serum; Urine; UrineJurkat T cell line |
Years | 2005-2015 |
Site | Identified Peptides | Year(Publication ID) |
---|---|---|
85 | VHPnLTSL | 2014(33); |
85 | VHPnLTSLDF | 2014(33); |
85 | DLFVHPnLTSL | 2014(33); |
85 | DLFVHPnLTSLD | 2014(33); |
85 | DLFVHPnLTSLDF | 2014(33); |
85 | VHPnLTSLDFVASEK | 2014(33); |
85 | DLFVHPnLTSLDFVASE | 2014(33); |
85 | LFVHPnLTSLDFVASEK | 2014(33); |
85 | DLFVHPnLTSLDFVASEK | 2014(33); |
85 | SVVIPLHYDLFVHPnLTSLDFVASEK | 2015(unpublished); |
85 | IPSVVIPIHYDIFVHPnITSIDFVASEK | 2014(16); |
85 | LPSVVIPLHYDLFVHPnLTSLDFVASEK | 2014(33); 2015(unpublished); |
103 | VLVSnATQF | 2014(33); |
103 | IEVLVSnATQF | 2014(33); |
103 | IEVLVSnATQFIILH | 2015(unpublished); |
103 | VLVSnATQFIILHSK | 2014(33); |
103 | IEVIVSnATQFIIIHSK | 2014(16); 2014(32); 2014(32); |
103 | IEVLVSnATQFIILHSK | 2013(34); 2014(13); 2014(33); 2015(unpublished);2015(unpublished);2015(2); 2015(10); |
119 | ITnATLQSE | 2014(33); |
119 | ITnATLQSEE | 2014(33); |
119 | ITnATLQSEEDSR | 2014(33); |
119 | KDIEITnATIQSE | 2013(37); |
119 | DIEITnATIQSEEDSR | 2014(16); |
119 | DLEITnATLQSEEDSR | 2005( 81); 2012(47); 2012(48); 2013(34); 2013(34); 2013(40); 2014(13); 2014(14); 2014(22); 2014(33); 2015(1); 2015(2); 2015(unpublished);2015(unpublished);2015(unpublished);2015;2015;2007;2007;2007; |
119 | HSKDLEITnATLQSEEDSRY | 2014(33); |
119 | IILHSKDLEITnATLQSEEDSRY | 2014(33); |
219 | AnFSIK | 2014(33); 2015(2); |
219 | AnFSIKIRR | 2007(unpublished);2007(unpublished);2007; |
294 | ASPDKRnQTHY | 2014(33); |
294 | nQTHYALQASLK | 2013(40); 2014(13); 2014(33); 2015(unpublished); |
294 | RnQTHYAIQASIK | 2014(16); |
405 | LIAVnATYPE | 2014(33); |
431 | DSLnSSRPISK | 2012(48); 2014(14); 2014(33); 2015(unpublished);2015(unpublished); |
431 | ITKDSInSSRPIS | 2013(37); |
431 | EVITKDSLnSSRPI | 2014(33); |
431 | DSLnSSRPISKPAETPTQIQE | 2014(33); |
431 | VITKDSLnSSRPISKPAETPTQIQE | 2014(33); |
431 | DSInSSRPISKPAETPTQIQEMFDEVSYNK | 2014(16); |
650 | NQnHTLL | 2014(33); |
650 | EGHGWDQLITQLNQnHTLL | 2014(33); |
650 | GHGWDQLITQLNQnHTLLRPK | 2014(33); |
650 | FNVDSNGYYIVHYEGHGWDQLITQLNQnHTLLRPK | 2015(unpublished); |
714 | nISDISENLK | 2013(40); 2014(33); 2015(unpublished); |
714 | nISDISENLKR | 2014(33); 2015(unpublished);2015(unpublished); |
714 | RnISDISENLK | 2012(48); 2014(33); 2015(unpublished); |
714 | RnISDISENIKR | 2014(16); |
714 | RnISDISENLKR | 2007(13); 2014(unpublished);2007(unpublished);2007; |
1 | 11 | 21 | 31 | 41 | 51 | 61 | 71 | 81 | 91 |
MFHSSAMVNS | HRKPMFNIHR | GFYCLTAILP | QICICSQFSV | PSSYHFTEDP | GAFPVATNGE | RFPWQELRLP | SVVIPLHYDL | FVHPNLTSLD | FVASEKIEVL |
101 | 111 | 121 | 131 | 141 | 151 | 161 | 171 | 181 | 191 |
VSNATQFIIL | HSKDLEITNA | TLQSEEDSRY | MKPGKELKVL | SYPAHEQIAL | LVPEKLTPHL | KYYVAMDFQA | KLGDGFEGFY | KSTYRTLGGE | TRILAVTDFE |
201 | 211 | 221 | 231 | 241 | 251 | 261 | 271 | 281 | 291 |
PTQARMAFPC | FDEPLFKANF | SIKIRRESRH | IALSNMPKVK | TIELEGGLLE | DHFETTVKMS | TYLVAYIVCD | FHSLSGFTSS | GVKVSIYASP | DKRNQTHYAL |
301 | 311 | 321 | 331 | 341 | 351 | 361 | 371 | 381 | 391 |
QASLKLLDFY | EKYFDIYYPL | SKLDLIAIPD | FAPGAMENWG | LITYRETSLL | FDPKTSSASD | KLWVTRVIAH | ELAHQWFGNL | VTMEWWNDIW | LKEGFAKYME |
401 | 411 | 421 | 431 | 441 | 451 | 461 | 471 | 481 | 491 |
LIAVNATYPE | LQFDDYFLNV | CFEVITKDSL | NSSRPISKPA | ETPTQIQEMF | DEVSYNKGAC | ILNMLKDFLG | EEKFQKGIIQ | YLKKFSYRNA | KNDDLWSSLS |
501 | 511 | 521 | 531 | 541 | 551 | 561 | 571 | 581 | 591 |
NSCLESDFTS | GGVCHSDPKM | TSNMLAFLGE | NAEVKEMMTT | WTLQKGIPLL | VVKQDGCSLR | LQQERFLQGV | FQEDPEWRAL | QERYLWHIPL | TYSTSSSNVI |
601 | 611 | 621 | 631 | 641 | 651 | 661 | 671 | 681 | 691 |
HRHILKSKTD | TLDLPEKTSW | VKFNVDSNGY | YIVHYEGHGW | DQLITQLNQN | HTLLRPKDRV | GLIHDVFQLV | GAGRLTLDKA | LDMTYYLQHE | TSSPALLEGL |
701 | 711 | 721 | 731 | 741 | 751 | 761 | 771 | 781 | 791 |
SYLESFYHMM | DRRNISDISE | NLKRYLLQYF | KPVIDRQSWS | DKGSVWDRML | RSALLKLACD | LNHAPCIQKA | AELFSQWMES | SGKLNIPTDV | LKIVYSVGAQ |
801 | 811 | 821 | 831 | 841 | 851 | 861 | 871 | 881 | 891 |
TTAGWNYLLE | QYELSMSSAE | QNKILYALST | SKHQEKLLKL | IELGMEGKVI | KTQNLAALLH | AIARRPKGQQ | LAWDFVRENW | THLLKKFDLG | SYDIRMIISG |
901 | 911 | 921 | 931 | 941 | 951 | ||||
TTAHFSSKDK | LQEVKLFFES | LEAQGSHLDI | FQTVLETITK | NIKWLEKNLP | TLRTWLMVNT |
ID | Publication |
---|---|
1 | Sun S, Shah P, Eshghi ST, Yang W, Trikannad N, Yang S, Chen L, Aiyetan P, Hoti N, Zhang Z, et al: Comprehensive analysis of protein glycosylation by solid-phase extraction of N-linked glycans and glycosite-containing peptides. Nat Biotech 2015, advance online publication. |
2 | Shah P, Wang X, Yang W, Eshghi ST, Sun S, Hoti N, Chen L, Yang S, Pasay J, Rubin A: Integrated Proteomic and Glycoproteomic Analyses of Prostate Cancer Cells Reveal Glycoprotein Alteration in Protein Abundance and Glycosylation. Molecular & Cellular Proteomics 2015, 14:2753-2763. |
10 | Tan ZJ, Yin HD, Nie S, Lin ZX, Zhu JH, Ruffin MT, Anderson MA, Simone DM, Lubman DM: Large-Scale Identification of Core-Fucosylated Glycopeptide Sites in Pancreatic Cancer Serum Using Mass Spectrometry. Journal of Proteome Research 2015, 14:1968-1978. |
13 | Yang W, Laeyendecker O, Wendel SK, Zhang B, Sun S, Zhou J-Y, Ao M, Moore RD, Jackson JB, Zhang H: Glycoproteomic Study Reveals Altered Plasma Proteins Associated with HIV Elite Suppressors. Theranostics 2014, 4:1153. |
14 | Liu Y, Chen J, Sethi A, Li QK, Chen L, Collins B, Gillet LC, Wollscheid B, Zhang H, Aebersold R: Glycoproteomic analysis of prostate cancer tissues by SWATH mass spectrometry discovers N-acylethanolamine acid amidase and protein tyrosine kinase 7 as signatures for tumor aggressiveness. Molecular & Cellular Proteomics 2014, 13:1753-1768. |
16 | Deeb SJ, Cox J, Schmidt-Supprian M, Mann M: N-linked Glycosylation Enrichment for In-depth Cell Surface Proteomics of Diffuse Large B-cell Lymphoma Subtypes. Molecular & Cellular Proteomics 2014, 13:240-251. |
22 | Nicastri A, Gaspari M, Sacco R, Elia L, Gabriele C, Romano R, Rizzuto A, Cuda G: N-Glycoprotein Analysis Discovers New Up-Regulated Glycoproteins in Colorectal Cancer Tissue. Journal of Proteome Research 2014, 13:4932-4941. |
32 | Zhang Z, Sun Z, Zhu J, Liu J, Huang G, Ye M, Zou H: High-Throughput Determination of the Site-Specific N-Sialoglycan Occupancy Rates by Differential Oxidation of Glycoproteins Followed with Quantitative Glycoproteomics Analysis. Analytical Chemistry 2014, 86:9830-9837. |
33 | Zhu J, Sun Z, Cheng K, Chen R, Ye M, Xu B, Sun D, Wang L, Liu J, Wang F, Zou H: Comprehensive Mapping of Protein N-Glycosylation in Human Liver by Combining Hydrophilic Interaction Chromatography and Hydrazide Chemistry. Journal of Proteome Research 2014, 13:1713-1721. |
34 | Sun S, Zhang B, Aiyetan P, Zhou J-Y, Shah P, Yang W, Levine DA, Zhang Z, Chan DW, Zhang H: Analysis of N-glycoproteins using Genomic N-glycosite Prediction. Journal of Proteome Research 2013, 12:5609-5615. |
37 | Boersema PJ, Geiger T, Wisniewski JR, Mann M: Quantification of the N-glycosylated Secretome by Super-SILAC During Breast Cancer Progression and in Human Blood Samples. Molecular & Cellular Proteomics 2013, 12:158-171. |
40 | Li X, Jiang J, Zhao X, Wang J, Han H, Zhao Y, Peng B, Zhong R, Ying W, Qian X: N-glycoproteome Analysis of the Secretome of Human Metastatic Hepatocellular Carcinoma Cell Lines Combining Hydrazide Chemistry, HILIC Enrichment and Mass Spectrometry. Plos One 2013, 8. |
47 | Almaraz RT, Tian Y, Bhattarcharya R, Tan E, Chen S-H, Dallas MR, Chen L, Zhang Z, Zhang H, Konstantopoulos K: Metabolic flux increases glycoprotein sialylation: implications for cell adhesion and cancer metastasis. Molecular & Cellular Proteomics 2012, 11:M112. 017558. |
48 | Danzer C, Eckhardt K, Schmidt A, Fankhauser N, Ribrioux S, Wollscheid B, Mueller L, Schiess R, Zuellig R, Lehmann R, et al: Comprehensive Description of the N-Glycoproteome of Mouse Pancreatic beta-Cells and Human Islets. Journal of Proteome Research 2012, 11:1598-1608. |