| Protein | E3 ubiquitin-protein ligase HUWE1 |
| Gene | HUWE1 |
| Status | Reviewed |
| Source | Colorectal tumors; Jurkat T cell line; OVCAR-3 cell line (Ovarian cancer); Prostate tumor; Serum |
| Years | 2007-2015 |
| Site | Identified Peptides | Year(Publication ID) |
|---|---|---|
| 742 | SNHAAEEASSEDEEEEEVQAMQSFnSTQQNETEPNQQVVGTEER | 2015(unpublished); |
| 747 | SNHAAEEASSEDEEEEEVQAMQSFNSTQQnETEPNQQVVGTEER | 2015(unpublished); |
| 1341 | EHAMEALLnTSTMEQATEYLLTHPPPIMGGVVR | 2009(68); |
| 1806 | ILnLTQSSGFNGFTPLVTLLLR | 2007(unpublished);2007(unpublished); |
| 2364 | DGGSGnSTIIVSR | 2014(13); |
| 2389 | nLSQASTLQANR | 2015(1); |
| 3399 | LDNMnVSRK | 2009(68); |
| 1 | 11 | 21 | 31 | 41 | 51 | 61 | 71 | 81 | 91 |
| MKVDRTKLKK | TPTEAPADCR | ALIDKLKVCN | DEQLLLELQQ | IKTWNIGKCE | LYHWVDLLDR | FDGILADAGQ | TVENMSWMLV | CDRPEREQLK | MLLLAVLNFT |
| 101 | 111 | 121 | 131 | 141 | 151 | 161 | 171 | 181 | 191 |
| ALLIEYSFSR | HLYSSIEHLT | TLLASSDMQV | VLAVLNLLYV | FSKRSNYITR | LGSDKRTPLL | TRLQHLAESW | GGKENGFGLA | ECCRDLHMMK | YPPSATTLHF |
| 201 | 211 | 221 | 231 | 241 | 251 | 261 | 271 | 281 | 291 |
| EFYADPGAEV | KIEKRTTSNT | LHYIHIEQLD | KISESPSEIM | ESLTKMYSIP | KDKQMLLFTH | IRLAHGFSNH | RKRLQAVQAR | LHAISILVYS | NALQESANSI |
| 301 | 311 | 321 | 331 | 341 | 351 | 361 | 371 | 381 | 391 |
| LYNGLIEELV | DVLQITDKQL | MEIKAASLRT | LTSIVHLERT | PKLSSIIDCT | GTASYHGFLP | VLVRNCIQAM | IDPSMDPYPH | QFATALFSFL | YHLASYDAGG |
| 401 | 411 | 421 | 431 | 441 | 451 | 461 | 471 | 481 | 491 |
| EALVSCGMME | ALLKVIKFLG | DEQDQITFVT | RAVRVVDLIT | NLDMAAFQSH | SGLSIFIYRL | EHEVDLCRKE | CPFVIKPKIQ | RPNTTQEGEE | METDMDGVQC |
| 501 | 511 | 521 | 531 | 541 | 551 | 561 | 571 | 581 | 591 |
| IPQRAALLKS | MLNFLKKAIQ | DPAFSDGIRH | VMDGSLPTSL | KHIISNAEYY | GPSLFLLATE | VVTVFVFQEP | SLLSSLQDNG | LTDVMLHALL | IKDVPATREV |
| 601 | 611 | 621 | 631 | 641 | 651 | 661 | 671 | 681 | 691 |
| LGSLPNVFSA | LCLNARGLQS | FVQCQPFERL | FKVLLSPDYL | PAMRRRRSSD | PLGDTASNLG | SAVDELMRHQ | PTLKTDATTA | IIKLLEEICN | LGRDPKYICQ |
| 701 | 711 | 721 | 731 | 741 | 751 | 761 | 771 | 781 | 791 |
| KPSIQKADGT | ATAPPPRSNH | AAEEASSEDE | EEEEVQAMQS | FNSTQQNETE | PNQQVVGTEE | RIPIPLMDYI | LNVMKFVESI | LSNNTTDDHC | QEFVNQKGLL |
| 801 | 811 | 821 | 831 | 841 | 851 | 861 | 871 | 881 | 891 |
| PLVTILGLPN | LPIDFPTSAA | CQAVAGVCKS | ILTLSHEPKV | LQEGLLQLDS | ILSSLEPLHR | PIESPGGSVL | LRELACAGNV | ADATLSAQAT | PLLHALTAAH |
| 901 | 911 | 921 | 931 | 941 | 951 | 961 | 971 | 981 | 991 |
| AYIMMFVHTC | RVGQSEIRSI | SVNQWGSQLG | LSVLSKLSQL | YCSLVWESTV | LLSLCTPNSL | PSGCEFGQAD | MQKLVPKDEK | AGTTQGGKRS | DGEQDGAAGS |
| 1001 | 1011 | 1021 | 1031 | 1041 | 1051 | 1061 | 1071 | 1081 | 1091 |
| MDASTQGLLE | GIGLDGDTLA | PMETDEPTAS | DSKGKSKITP | AMAARIKQIK | PLLSASSRLG | RALAELFGLL | VKLCVGSPVR | QRRSHHAAST | TTAPTPAARS |
| 1101 | 1111 | 1121 | 1131 | 1141 | 1151 | 1161 | 1171 | 1181 | 1191 |
| TASALTKLLT | KGLSWQPPPY | TPTPRFRLTF | FICSVGFTSP | MLFDERKYPY | HLMLQKFLCS | GGHNALFETF | NWALSMGGKV | PVSEGLEHSD | LPDGTGEFLD |
| 1201 | 1211 | 1221 | 1231 | 1241 | 1251 | 1261 | 1271 | 1281 | 1291 |
| AWLMLVEKMV | NPTTVLESPH | SLPAKLPGGV | QNFPQFSALR | FLVVTQKAAF | TCIKNLWNRK | PLKVYGGRMA | ESMLAILCHI | LRGEPVIRER | LSKEKEGSRG |
| 1301 | 1311 | 1321 | 1331 | 1341 | 1351 | 1361 | 1371 | 1381 | 1391 |
| EEDTGQEEGG | SRREPQVNQQ | QLQQLMDMGF | TREHAMEALL | NTSTMEQATE | YLLTHPPPIM | GGVVRDLSMS | EEDQMMRAIA | MSLGQDIPMD | QRAESPEEVA |
| 1401 | 1411 | 1421 | 1431 | 1441 | 1451 | 1461 | 1471 | 1481 | 1491 |
| CRKEEEERKA | REKQEEEEAK | CLEKFQDADP | LEQDELHTFT | DTMLPGCFHL | LDELPDTVYR | VCDLIMTAIK | RNGADYRDMI | LKQVVNQVWE | AADVLIKAAL |
| 1501 | 1511 | 1521 | 1531 | 1541 | 1551 | 1561 | 1571 | 1581 | 1591 |
| PLTTSDTKTV | SEWISQMATL | PQASNLATRI | LLLTLLFEEL | KLPCAWVVES | SGILNVLIKL | LEVVQPCLQA | AKEQKEVQTP | KWITPVLLLI | DFYEKTAISS |
| 1601 | 1611 | 1621 | 1631 | 1641 | 1651 | 1661 | 1671 | 1681 | 1691 |
| KRRAQMTKYL | QSNSNNWRWF | DDRSGRWCSY | SASNNSTIDS | AWKSGETSVR | FTAGRRRYTV | QFTTMVQVNE | ETGNRRPVML | TLLRVPRLNK | NSKNSNGQEL |
| 1701 | 1711 | 1721 | 1731 | 1741 | 1751 | 1761 | 1771 | 1781 | 1791 |
| EKTLEESKEM | DIKRKENKGN | DTPLALESTN | TEKETSLEET | KIGEILIQGL | TEDMVTVLIR | ACVSMLGVPV | DPDTLHATLR | LCLRLTRDHK | YAMMFAELKS |
| 1801 | 1811 | 1821 | 1831 | 1841 | 1851 | 1861 | 1871 | 1881 | 1891 |
| TRMILNLTQS | SGFNGFTPLV | TLLLRHIIED | PCTLRHTMEK | VVRSAATSGA | GSTTSGVVSG | SLGSREINYI | LRVLGPAACR | NPDIFTEVAN | CCIRIALPAP |
| 1901 | 1911 | 1921 | 1931 | 1941 | 1951 | 1961 | 1971 | 1981 | 1991 |
| RGSGTASDDE | FENLRIKGPN | AVQLVKTTPL | KPSPLPVIPD | TIKEVIYDML | NALAAYHAPE | EADKSDPKPG | VMTQEVGQLL | QDMGDDVYQQ | YRSLTRQSSD |
| 2001 | 2011 | 2021 | 2031 | 2041 | 2051 | 2061 | 2071 | 2081 | 2091 |
| FDTQSGFSIN | SQVFAADGAS | TETSASGTSQ | GEASTPEESR | DGKKDKEGDR | ASEEGKQKGK | GSKPLMPTST | ILRLLAELVR | SYVGIATLIA | NYSYTVGQSE |
| 2101 | 2111 | 2121 | 2131 | 2141 | 2151 | 2161 | 2171 | 2181 | 2191 |
| LIKEDCSVLA | FVLDHLLPHT | QNAEDKDTPA | LARLFLASLA | AAGSGTDAQV | ALVNEVKAAL | GRALAMAEST | EKHARLQAVM | CIISTIMESC | PSTSSFYSSA |
| 2201 | 2211 | 2221 | 2231 | 2241 | 2251 | 2261 | 2271 | 2281 | 2291 |
| TAKTQHNGMN | NIIRLFLKKG | LVNDLARVPH | SLDLSSPNMA | NTVNAALKPL | ETLSRIVNQP | SSLFGSKSAS | SKNKSEQDAQ | GASQDSSSNQ | QDPGEPGEAE |
| 2301 | 2311 | 2321 | 2331 | 2341 | 2351 | 2361 | 2371 | 2381 | 2391 |
| VQEEDHDVTQ | TEVADGDIMD | GEAETDSVVI | AGQPEVLSSQ | EMQVENELED | LIDELLERDG | GSGNSTIIVS | RSGEDESQED | VLMDEAPSNL | SQASTLQANR |
| 2401 | 2411 | 2421 | 2431 | 2441 | 2451 | 2461 | 2471 | 2481 | 2491 |
| EDSMNILDPE | DEEEHTQEED | SSGSNEDEDD | SQDEEEEEEE | DEEDDQEDDE | GEEGDEDDDD | DGSEMELDED | YPDMNASPLV | RFERFDREDD | LIIEFDNMFS |
| 2501 | 2511 | 2521 | 2531 | 2541 | 2551 | 2561 | 2571 | 2581 | 2591 |
| SATDIPPSPG | NIPTTHPLMV | RHADHSSLTL | GSGSSTTRLT | QGIGRSQRTL | RQLTANTGHT | IHVHYPGNRQ | PNPPLILQRL | LGPSAAADIL | QLSSSLPLQS |
| 2601 | 2611 | 2621 | 2631 | 2641 | 2651 | 2661 | 2671 | 2681 | 2691 |
| RGRARLLVGN | DDVHIIARSD | DELLDDFFHD | QSTATSQAGT | LSSIPTALTR | WTEECKVLDA | ESMHDCVSVV | KVSIVNHLEF | LRDEELEERR | EKRRKQLAEE |
| 2701 | 2711 | 2721 | 2731 | 2741 | 2751 | 2761 | 2771 | 2781 | 2791 |
| ETKITDKGKE | DKENRDQSAQ | CTASKSNDST | EQNLSDGTPM | PDSYPTTPSS | TDAATSESKE | TLGTLQSSQQ | QPTLPTPPAL | GEVPQELQSP | AGEGGSSTQL |
| 2801 | 2811 | 2821 | 2831 | 2841 | 2851 | 2861 | 2871 | 2881 | 2891 |
| LMPVEPEELG | PTRPSGEAET | TQMELSPAPT | ITSLSPERAE | DSDALTAVSS | QLEGSPMDTS | SLASCTLEEA | VGDTSAAGSS | EQPRAGSSTP | GDAPPAVAEV |
| 2901 | 2911 | 2921 | 2931 | 2941 | 2951 | 2961 | 2971 | 2981 | 2991 |
| QGRSDGSGES | AQPPEDSSPP | ASSESSSTRD | SAVAISGADS | RGILEEPLPS | TSSEEEDPLA | GISLPEGVDP | SFLAALPDDI | RREVLQNQLG | IRPPTRTAPS |
| 3001 | 3011 | 3021 | 3031 | 3041 | 3051 | 3061 | 3071 | 3081 | 3091 |
| TNSSAPAVVG | NPGVTEVSPE | FLAALPPAIQ | EEVLAQQRAE | QQRRELAQNA | SSDTPMDPVT | FIQTLPSDLR | RSVLEDMEDS | VLAVMPPDIA | AEAQALRREQ |
| 3101 | 3111 | 3121 | 3131 | 3141 | 3151 | 3161 | 3171 | 3181 | 3191 |
| EARQRQLMHE | RLFGHSSTSA | LSAILRSPAF | TSRLSGNRGV | QYTRLAVQRG | GTFQMGGSSS | HNRPSGSNVD | TLLRLRGRLL | LDHEALSCLL | VLLFVDEPKL |
| 3201 | 3211 | 3221 | 3231 | 3241 | 3251 | 3261 | 3271 | 3281 | 3291 |
| NTSRLHRVLR | NLCYHAQTRH | WVIRSLLSIL | QRSSESELCI | ETPKLTTSEE | KGKKSSKSCG | SSSHENRPLD | LLHKMESKSS | NQLSWLSVSM | DAALGCRTNI |
| 3301 | 3311 | 3321 | 3331 | 3341 | 3351 | 3361 | 3371 | 3381 | 3391 |
| FQIQRSGGRK | HTEKHASGGS | TVHIHPQAAP | VVCRHVLDTL | IQLAKVFPSH | FTQQRTKETN | CESDRERGNK | ACSPCSSQSS | SSGICTDFWD | LLVKLDNMNV |
| 3401 | 3411 | 3421 | 3431 | 3441 | 3451 | 3461 | 3471 | 3481 | 3491 |
| SRKGKNSVKS | VPVSAGGEGE | TSPYSLEASP | LGQLMNMLSH | PVIRRSSLLT | EKLLRLLSLI | SIALPENKVS | EAQANSGSGA | SSTTTATSTT | STTTTTAAST |
| 3501 | 3511 | 3521 | 3531 | 3541 | 3551 | 3561 | 3571 | 3581 | 3591 |
| TPTPPTAPTP | VTSAPALVAA | TAISTIVVAA | STTVTTPTTA | TTTVSISPTT | KGSKSPAKVS | DGGSSSTDFK | MVSSGLTENQ | LQLSVEVLTS | HSCSEEGLED |
| 3601 | 3611 | 3621 | 3631 | 3641 | 3651 | 3661 | 3671 | 3681 | 3691 |
| AANVLLQLSR | GDSGTRDTVL | KLLLNGARHL | GYTLCKQIGT | LLAELREYNL | EQQRRAQCET | LSPDGLPEEQ | PQTTKLKGKM | QSRFDMAENV | VIVASQKRPL |
| 3701 | 3711 | 3721 | 3731 | 3741 | 3751 | 3761 | 3771 | 3781 | 3791 |
| GGRELQLPSM | SMLTSKTSTQ | KFFLRVLQVI | IQLRDDTRRA | NKKAKQTGRL | GSSGLGSASS | IQAAVRQLEA | EADAIIQMVR | EGQRARRQQQ | AATSESSQSE |
| 3801 | 3811 | 3821 | 3831 | 3841 | 3851 | 3861 | 3871 | 3881 | 3891 |
| ASVRREESPM | DVDQPSPSAQ | DTQSIASDGT | PQGEKEKEER | PPELPLLSEQ | LSLDELWDML | GECLKELEES | HDQHAVLVLQ | PAVEAFFLVH | ATERESKPPV |
| 3901 | 3911 | 3921 | 3931 | 3941 | 3951 | 3961 | 3971 | 3981 | 3991 |
| RDTRESQLAH | IKDEPPPLSP | APLTPATPSS | LDPFFSREPS | SMHISSSLPP | DTQKFLRFAE | THRTVLNQIL | RQSTTHLADG | PFAVLVDYIR | VLDFDVKRKY |
| 4001 | 4011 | 4021 | 4031 | 4041 | 4051 | 4061 | 4071 | 4081 | 4091 |
| FRQELERLDE | GLRKEDMAVH | VRRDHVFEDS | YRELHRKSPE | EMKNRLYIVF | EGEEGQDAGG | LLREWYMIIS | REMFNPMYAL | FRTSPGDRVT | YTINPSSHCN |
| 4101 | 4111 | 4121 | 4131 | 4141 | 4151 | 4161 | 4171 | 4181 | 4191 |
| PNHLSYFKFV | GRIVAKAVYD | NRLLECYFTR | SFYKHILGKS | VRYTDMESED | YHFYQGLVYL | LENDVSTLGY | DLTFSTEVQE | FGVCEVRDLK | PNGANILVTE |
| 4201 | 4211 | 4221 | 4231 | 4241 | 4251 | 4261 | 4271 | 4281 | 4291 |
| ENKKEYVHLV | CQMRMTGAIR | KQLAAFLEGF | YEIIPKRLIS | IFTEQELELL | ISGLPTIDID | DLKSNTEYHK | YQSNSIQIQW | FWRALRSFDQ | ADRAKFLQFV |
| 4301 | 4311 | 4321 | 4331 | 4341 | 4351 | 4361 | 4371 | ||
| TGTSKVPLQG | FAALEGMNGI | QKFQIHRDDR | STDRLPSAHT | CFNQLDLPAY | ESFEKLRHML | LLAIQECSEG | FGLA |
| ID | Publication |
|---|---|
| 1 | Sun S, Shah P, Eshghi ST, Yang W, Trikannad N, Yang S, Chen L, Aiyetan P, Hoti N, Zhang Z, et al: Comprehensive analysis of protein glycosylation by solid-phase extraction of N-linked glycans and glycosite-containing peptides. Nat Biotech 2015, advance online publication. |
| 13 | Yang W, Laeyendecker O, Wendel SK, Zhang B, Sun S, Zhou J-Y, Ao M, Moore RD, Jackson JB, Zhang H: Glycoproteomic Study Reveals Altered Plasma Proteins Associated with HIV Elite Suppressors. Theranostics 2014, 4:1153. |
| 68 | Zhang L, Xu Y, Yao H, Xie L, Yao J, Lu H, Yang P: Boronic Acid Functionalized Core-Satellite Composite Nanoparticles for Advanced Enrichment of Glycopeptides and Glycoproteins. Chemistry-a European Journal 2009, 15:10158-10166. |