Contains      

UniProtKB-Q86SQ4

Protein G-protein coupled receptor 126
Gene GPR126
Status Reviewed
Source Breast Cancer cell lines; Breast cancer xenografts; Breast cell lines; Colorectal cancer cell line, HCT-116 (colorectal cancer); Colorectal tumor; HCC cell lines (Liver); Hela cell line (cervical cancer); HepG2 cell line (Liver); HuH-7 cell line (Liver); LNCap/PC3 cell lines (Prostate cancer); Liver; OVCAR-3 cell line (Ovarian cancer); Ovarian tumor; Plasma; Prostate tumor; Serum; Urine; prostate cancer cell lines
Years 2005-2015

Glycosites

Site Identified Peptides Year(Publication ID)
121 SFnSSANEMHVSF 2014(33);
121 GLSFnSSANEMHVSF 2014(33);
121 GLSFnSSANEMHVSFSSDFSIQK 2015(2);
143 GFnASYIR 2005( 81); 2007(40); 2013(32); 2014(33); 2014(1); 2015(2); 2015(unpublished);2015(unpublished);2015(unpublished);2015;2015;2015;2015;2007;2007;2007;
143 KGFnASYIR 2014(33); 2015(2); 2015(unpublished);2015(unpublished);
143 IQKKGFnASYIRV 2013(37);
206 SYSnASFTQLL 2014(33);
206 nASFTQLLSFGK 2015(1);
206 VGHEDSDWTAFSYSnASFTQLLSFGK 2013(38); 2015(2);
314 LWnFTMNAK 2007(38); 2013(40); 2013(33); 2014(2); 2015(unpublished);2007(unpublished);2007;
314 YNFRIWnFTMNAK 2013(37);
324 ILSnLSCNVK 2007(52); 2012(38); 2013(38); 2013(40); 2013(22); 2014(33); 2014(1); 2015(12); 2015(unpublished);2015(unpublished);2015;2015;2015;2007;2007;
324 NAKIISnISCNVK 2013(37);
353 KAESnLSCGSY 2014(33);
485 nATNNTNLEGK 2015(1);
485 VYnATNNTNLEGK 2014(33);
485 LVYnATNNTNLEGK 2007(unpublished);2007(unpublished);2007;
485 LVLWALLVYnATNNTNLEGK 2015(1); 2015(2);
488 NATnNTNLEGK 2015(1);
488 VYNATnNTNLEGK 2014(33);
488 LVYNATnNTNLEGK 2007(unpublished);2007(unpublished);2007;
488 LVLWALLVYNATnNTNLEGK 2015(1); 2015(2);
505 NnESLDEGLR 2013(38); 2014(22); 2014(33); 2015(2); 2015(unpublished);2015(unpublished);2015(unpublished);
505 LLKNnESLDEGLR 2007(72); 2015(1); 2015(2); 2015(unpublished);2015(unpublished);
505 QKIIKNnESIDEG 2013(37);
505 NnESLDEGLRLHTVNVR 2011(58); 2013(38); 2013(38);
505 LLKNnESLDEGLRLHTVNVR 2011(58);
605 nITNIVEQVK 2015(1);
667 IDLnSTSHVNITTR 2007(72); 2007(38); 2013(33); 2014(1); 2015(2); 2015(unpublished);2015(unpublished);2015;2015;2015;2007;2007;
667 TIDELAFKIDLnSTSHVNI 2005(81);
673 IDLNSTSHVnITTR 2007(72); 2007(38); 2013(33); 2014(1); 2015(2); 2015(unpublished);2015(unpublished);2015;2015;2015;2007;2007;
673 TIDELAFKIDLNSTSHVnI 2005(81);
704 SIGLPSNnESYF 2014(33);
750 AQFTFFnK 2007(33); 2014(2); 2015(unpublished);2015(unpublished);2015;2015;2015;2015;2007;2007;
750 RAQFTFFnK 2015(2);
750 AQFTFFnKTGIFQ 2013(37);
750 AQFTFFnKTGLFQDVGPQRK 2011(58);
776 nITIQNLK 2015(1);
776 nITIQNLKDPVQIK 2015(1);
776 KTLVSYVMACSIGnITIQN 2007(unpublished);2007(unpublished);2007;
811 DLNKnKSF 2014(33);
811 DLNKnKSFGGW 2014(33);
811 FWDINKnKSFGGW 2013(37);
811 TQEVHHPICAFWDLNKnK 2014(33);
818 nTSGCVAHR 2015(1);
818 KSFGGWnTSGCVA 2013(37);
818 SFGGWnTSGCVAHR 2011(58); 2013(45); 2014(33); 2015(unpublished);
818 nTSGCVAHRDSDASETVCL 2014(33);

Sequence

1112131415161718191
MMFRSDRMWSCHWKWKPSPLLFLFALYIMCVPHSVWGCANCRVVLSNPSGTFTSPCYPNDYPNSQACMWTLRAPTGYIIQITFNDFDIEEAPNCIYDSLS
101111121131141151161171181191
LDNGESQTKFCGATAKGLSFNSSANEMHVSFSSDFSIQKKGFNASYIRVAVSLRNQKVILPQTSDAYQVSVAKSISIPELSAFTLCFEATKVGHEDSDWT
201211221231241251261271281291
AFSYSNASFTQLLSFGKAKSGYFLSISDSKCLLNNALPVKEKEDIFAESFEQLCLVWNNSLGSIGVNFKRNYETVPCDSTISKVIPGNGKLLLGSNQNEI
301311321331341351361371381391
VSLKGDIYNFRLWNFTMNAKILSNLSCNVKGNVVDWQNDFWNIPNLALKAESNLSCGSYLIPLPAAELASCADLGTLCQATVNSPSTTPPTVTTNMPVTN
401411421431441451461471481491
RIDKQRNDGIIYRISVVIQNILRHPEVKVQSKVAEWLNSTFQNWNYTVYVVNISFHLSAGEDKIKVKRSLEDEPRLVLWALLVYNATNNTNLEGKIIQQK
501511521531541551561571581591
LLKNNESLDEGLRLHTVNVRQLGHCLAMEEPKGYYWPSIQPSEYVLPCPDKPGFSASRICFYNATNPLVTYWGPVDISNCLKEANEVANQILNLTADGQN
601611621631641651661671681691
LTSANITNIVEQVKRIVNKEENIDITLGSTLMNIFSNILSSSDSDLLESSSEALKTIDELAFKIDLNSTSHVNITTRNLALSVSSLLPGTNAISNFSIGL
701711721731741751761771781791
PSNNESYFQMDFESGQVDPLASVILPPNLLENLSPEDSVLVRRAQFTFFNKTGLFQDVGPQRKTLVSYVMACSIGNITIQNLKDPVQIKIKHTRTQEVHH
801811821831841851861871881891
PICAFWDLNKNKSFGGWNTSGCVAHRDSDASETVCLCNHFTHFGVLMDLPRSASQLDARNTKVLTFISYIGCGISAIFSAATLLTYVAFEKLRRDYPSKI
901911921931941951961971981991
LMNLSTALLFLNLLFLLDGWITSFNVDGLCIAVAVLLHFFLLATFTWMGLEAIHMYIALVKVFNTYIRRYILKFCIIGWGLPALVVSVVLASRNNNEVYG
1001101110211031104110511061107110811091
KESYGKEKGDEFCWIQDPVIFYVTCAGYFGVMFFLNIAMFIVVMVQICGRNGKRSNRTLREEVLRNLRSVVSLTFLLGMTWGFAFFAWGPLNIPFMYLFS
1101111111211131114111511161117111811191
IFNSLQGLFIFIFHCAMKENVQKQWRQHLCCGRFRLADNSDWSKTATNIIKKSSDNLGKSLSSSSIGSNSTYLTSKSKSSSTTYFKRNSHTDNVSYEHSF
120112111221
NKSGSLRQCFHGQVLVKTGPC

Reference

ID Publication
1Sun S, Shah P, Eshghi ST, Yang W, Trikannad N, Yang S, Chen L, Aiyetan P, Hoti N, Zhang Z, et al: Comprehensive analysis of protein glycosylation by solid-phase extraction of N-linked glycans and glycosite-containing peptides. Nat Biotech 2015, advance online publication.
2Shah P, Wang X, Yang W, Eshghi ST, Sun S, Hoti N, Chen L, Yang S, Pasay J, Rubin A: Integrated Proteomic and Glycoproteomic Analyses of Prostate Cancer Cells Reveal Glycoprotein Alteration in Protein Abundance and Glycosylation. Molecular & Cellular Proteomics 2015, 14:2753-2763.
12Weng Y, Sui Z, Jiang H, Shan Y, Chen L, Zhang S, Zhang L, Zhang Y: Releasing N-glycan from Peptide N-terminus by N-terminal Succinylation Assisted Enzymatic Deglycosylation. Scientific Reports 2015, 5.
22Nicastri A, Gaspari M, Sacco R, Elia L, Gabriele C, Romano R, Rizzuto A, Cuda G: N-Glycoprotein Analysis Discovers New Up-Regulated Glycoproteins in Colorectal Cancer Tissue. Journal of Proteome Research 2014, 13:4932-4941.
32Zhang Z, Sun Z, Zhu J, Liu J, Huang G, Ye M, Zou H: High-Throughput Determination of the Site-Specific N-Sialoglycan Occupancy Rates by Differential Oxidation of Glycoproteins Followed with Quantitative Glycoproteomics Analysis. Analytical Chemistry 2014, 86:9830-9837.
33Zhu J, Sun Z, Cheng K, Chen R, Ye M, Xu B, Sun D, Wang L, Liu J, Wang F, Zou H: Comprehensive Mapping of Protein N-Glycosylation in Human Liver by Combining Hydrophilic Interaction Chromatography and Hydrazide Chemistry. Journal of Proteome Research 2014, 13:1713-1721.
37Boersema PJ, Geiger T, Wisniewski JR, Mann M: Quantification of the N-glycosylated Secretome by Super-SILAC During Breast Cancer Progression and in Human Blood Samples. Molecular & Cellular Proteomics 2013, 12:158-171.
38Kaji H, Ocho M, Togayachi A, Kuno A, Sogabe M, Ohkura T, Nozaki H, Angata T, Chiba Y, Ozaki H, et al: Glycoproteomic Discovery of Serological Biomarker Candidates for HCV/HBV Infection-Associated Liver Fibrosis and Hepatocellular Carcinoma. Journal of Proteome Research 2013, 12:2630-2640.
40Li X, Jiang J, Zhao X, Wang J, Han H, Zhao Y, Peng B, Zhong R, Ying W, Qian X: N-glycoproteome Analysis of the Secretome of Human Metastatic Hepatocellular Carcinoma Cell Lines Combining Hydrazide Chemistry, HILIC Enrichment and Mass Spectrometry. Plos One 2013, 8.
45Zhou H, Froehlich JW, Briscoe AC, Lee RS: The GlycoFilter: A Simple and Comprehensive Sample Preparation Platform for Proteomics, N-Glycomics and Glycosylation Site Assignment. Molecular & Cellular Proteomics 2013, 12:2981-2991.
52Yen T-Y, Macher BA, McDonald CA, Alleyne-Chin C, Timpe LC: Glycoprotein Profiles of Human Breast Cells Demonstrate a Clear Clustering of Normal/Benign versus Malignant Cell Lines and Basal versus Luminal Cell Lines. Journal of Proteome Research 2012, 11:656-667.
58Nagano K, Shinkawa T, Kato K, Inomata N, Yabuki N, Haramura M: Distinct cell surface proteome profiling by biotin labeling and glycoprotein capturing. Journal of Proteomics 2011, 74:1985-1993.
72Hanson SR, Hsu T-L, Weerapana E, Kishikawa K, Simon GM, Cravatt BF, Wong C-H: Tailored glycoproteomics and glycan site mapping using saccharide-selective bioorthogonal probes. Journal of the American Chemical Society 2007, 129:7266-+.
81Liu T, Qian WJ, Gritsenko MA, Camp DG, Monroe ME, Moore RJ, Smith RD: Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry. Journal of Proteome Research 2005, 4:2070-2080.