Detail

UniProtKB-Q8IY17


Protein	Neuropathy target esterase
Gene	PNPLA6
Status	Reviewed
Source	DLBCL cell lines (Diffuse large B-cell lymphoma); Liver; OVCAR-3 cell line (Ovarian cancer); Ovarian tumor; Pancreatic islets
Years	2012-2015

Glycosites

Site	Identified Peptides	Year(Publication ID)
11	GTSSHGIATnSSGAK	2014(16);
11	GTSSHGLATnSSGAK	2012(48); 2014(33); 2015(unpublished);2015(1);

Sequence

1	11	21	31	41	51	61	71	81	91
MGTSSHGLAT	NSSGAKVAER	DGFQDVLAPG	EGSAGRICGA	QPVPFVPQVL	GVMIGAGVAV	VVTAVLILLV	VRRLRVPKTP	APDGPRYRFR	KRDKVLFYGR
101	111	121	131	141	151	161	171	181	191
KIMRKVSQST	SSLVDTSVSA	TSRPRMRKKL	KMLNIAKKIL	RIQKETPTLQ	RKEPPPAVLE	ADLTEGDLAN	SHLPSEVLYM	LKNVRVLGHF	EKPLFLELCR
201	211	221	231	241	251	261	271	281	291
HMVFQRLGQG	DYVFRPGQPD	ASIYVVQDGL	LELCLPGPDG	KECVVKEVVP	GDSVNSLLSI	LDVITGHQHP	QRTVSARAAR	DSTVLRLPVE	AFSAVFTKYP
301	311	321	331	341	351	361	371	381	391
ESLVRVVQII	MVRLQRVTFL	ALHNYLGLTN	ELFSHEIQPL	RLFPSPGLPT	RTSPVRGSKR	MVSTSATDEP	RETPGRPPDP	TGAPLPGPTG	DPVKPTSLET
401	411	421	431	441	451	461	471	481	491
PSAPLLSRCV	SMPGDISGLQ	GGPRSDFDMA	YERGRISVSL	QEEASGGSLA	APARTPTQEP	REQPAGACEY	SYCEDESATG	GCPFGPYQGR	QTSSIFEAAK
501	511	521	531	541	551	561	571	581	591
QELAKLMRIE	DPSLLNSRVL	LHHAKAGTII	ARQGDQDVSL	HFVLWGCLHV	YQRMIDKAED	VCLFVAQPGE	LVGQLAVLTG	EPLIFTLRAQ	RDCTFLRISK
601	611	621	631	641	651	661	671	681	691
SDFYEIMRAQ	PSVVLSAAHT	VAARMSPFVR	QMDFAIDWTA	VEAGRALYRQ	GDRSDCTYIV	LNGRLRSVIQ	RGSGKKELVG	EYGRGDLIGV	VEALTRQPRA
701	711	721	731	741	751	761	771	781	791
TTVHAVRDTE	LAKLPEGTLG	HIKRRYPQVV	TRLIHLLSQK	ILGNLQQLQG	PFPAGSGLGV	PPHSELTNPA	SNLATVAILP	VCAEVPMVAF	TLELQHALQA
801	811	821	831	841	851	861	871	881	891
IGPTLLLNSD	IIRARLGASA	LDSIQEFRLS	GWLAQQEDAH	RIVLYQTDAS	LTPWTVRCLR	QADCILIVGL	GDQEPTLGQL	EQMLENTAVR	ALKQLVLLHR
901	911	921	931	941	951	961	971	981	991
EEGAGPTRTV	EWLNMRSWCS	GHLHLRCPRR	LFSRRSPAKL	HELYEKVFSR	RADRHSDFSR	LARVLTGNTI	ALVLGGGGAR	GCSHIGVLKA	LEEAGVPVDL
1001	1011	1021	1031	1041	1051	1061	1071	1081	1091
VGGTSIGSFI	GALYAEERSA	SRTKQRAREW	AKSMTSVLEP	VLDLTYPVTS	MFTGSAFNRS	IHRVFQDKQI	EDLWLPYFNV	TTDITASAMR	VHKDGSLWRY
1101	1111	1121	1131	1141	1151	1161	1171	1181	1191
VRASMTLSGY	LPPLCDPKDG	HLLMDGGYIN	NLPADIARSM	GAKTVIAIDV	GSQDETDLST	YGDSLSGWWL	LWKRLNPWAD	KVKVPDMAEI	QSRLAYVSCV
1201	1211	1221	1231	1241	1251	1261	1271	1281	1291
RQLEVVKSSS	YCEYLRPPID	CFKTMDFGKF	DQIYDVGYQY	GKAVFGGWSR	GNVIEKMLTD	RRSTDLNESR	RADVLAFPSS	GFTDLAEIVS	RIEPPTSYVS
1301	1311	1321	1331	1341	1351	1361
DGCADGEESD	CLTEYEEDAG	PDCSRDEGGS	PEGASPSTAS	EMEEEKSILR	QRRCLPQEPP	GSATDA

Reference

ID	Publication
1	Sun S, Shah P, Eshghi ST, Yang W, Trikannad N, Yang S, Chen L, Aiyetan P, Hoti N, Zhang Z, et al: Comprehensive analysis of protein glycosylation by solid-phase extraction of N-linked glycans and glycosite-containing peptides. Nat Biotech 2015, advance online publication.
16	Deeb SJ, Cox J, Schmidt-Supprian M, Mann M: N-linked Glycosylation Enrichment for In-depth Cell Surface Proteomics of Diffuse Large B-cell Lymphoma Subtypes. Molecular & Cellular Proteomics 2014, 13:240-251.
33	Zhu J, Sun Z, Cheng K, Chen R, Ye M, Xu B, Sun D, Wang L, Liu J, Wang F, Zou H: Comprehensive Mapping of Protein N-Glycosylation in Human Liver by Combining Hydrophilic Interaction Chromatography and Hydrazide Chemistry. Journal of Proteome Research 2014, 13:1713-1721.
48	Danzer C, Eckhardt K, Schmidt A, Fankhauser N, Ribrioux S, Wollscheid B, Mueller L, Schiess R, Zuellig R, Lehmann R, et al: Comprehensive Description of the N-Glycoproteome of Mouse Pancreatic beta-Cells and Human Islets. Journal of Proteome Research 2012, 11:1598-1608.