Contains      

UniProtKB-Q8IZA0

Protein Dyslexia-associated protein KIAA0319-like protein
Gene KIAA0319L
Status Reviewed
Source Breast cancer xenografts; Breast cell lines; Breast tumor; Cerebrospinal fluid; Colorectal cancer cell line, HCT-116 (colorectal cancer); DLBCL cell lines (Diffuse large B-cell lymphoma); Hela cell line (cervical cancer); LNCap/PC3 cell lines (Prostate cancer); Liver; Liver tumor (HCC); OVCAR-3 cell line (Ovarian cancer); Ovarian tumor; Pancreatic islets; Prostate; Prostate tumor; Urine
Years 2007-2015

Glycosites

Site Identified Peptides Year(Publication ID)
207 VnDSNEIGGITTSGSAEVHK 2014(16);
207 VnDSNELGGLTTSGSAEVHK 2015(unpublished);2015(1); 2015(2); 2015(unpublished);2015(unpublished);2015(unpublished);
247 nVSVQPEISEGLATTPSTQQVK 2015(unpublished);
395 nVTVKPEPR 2015(1);
395 VnVTVKPEPR 2014(33);
395 GYVnVTVKPEPR 2014(33);
395 GEGYVnVTVKPEPR 2012(48);
395 VIVEGQNAHGEGYVnVTVKPEPR 2007(52); 2012(14); 2014(33); 2014(1); 2015(2); 2015(unpublished);2015(unpublished);2015(unpublished);2015;2015;2007;2007;2007;
472 SKLVPGnY 2014(33);
472 KLSKLVPGnY 2014(33);
472 LVPGnYTFSLT 2012(48);
472 KLSKLVPGnYTF 2009(64);
487 nSTTANLTVNK 2015(1);
487 DSDGATnSTTANLTVNK 2007(unpublished);2007(unpublished);2007(unpublished);
487 SLTVVDSDGATnSTTANLTVNK 2015(unpublished);
492 NSTTAnLTVNK 2015(1);
492 DSDGATNSTTAnLTVNK 2007(unpublished);2007(unpublished);2007(unpublished);
492 SLTVVDSDGATNSTTAnLTVNK 2015(unpublished);
525 GnQSTDDHGITSY 2014(33);
525 FGnQSTDDHGITSY 2014(33);
525 FGnQSTDDHGITSYE 2009(64);
649 TQGPDGVQLENAnSSVA 2007(unpublished);2007(unpublished);
742 VLnHSDHHPILFLSNLVE 2014(33);
742 DEGSPAAGEVLnHSDHHPILF 2012(48); 2014(33);
742 TRDEGSPAAGEVLnHSDHHPILF 2014(33);
742 DEGSPAAGEVLnHSDHHPILFLSNLVEGTYTFHLK 2015(2);
890 nCSDHGHCDSFTK 2015(1);
890 VNTVTCQLnCSDHGHCDSFTK 2014(33);
890 VNTVTCQLnCSDHGHCDSFTKR 2014(33);
890 RALEVNTVTCQLnCSDHGHCDSF 2014(33);
890 AIEVNTVTCQInCSDHGHCDSFTK 2014(32); 2014(32);
890 ALEVNTVTCQLnCSDHGHCDSFTK 2011(58); 2012(48); 2012(52); 2014(33); 2015(1);
890 AIEVNTVTCQInCSDHGHCDSFTKR 2014(16);
890 ALEVNTVTCQLnCSDHGHCDSFTKR 2014(33); 2015(12);

Sequence

1112131415161718191
MEKRLGVKPNPASWILSGYYWQTSAKWLRSLYLFYTCFCFSVLWLSTDASESRCQQGKTQFGVGLRSGGENHLWLLEGTPSLQSCWAACCQDSACHVFWW
101111121131141151161171181191
LEGMCIQADCSRPQSCRAFRTHSSNSMLVFLKKFQTADDLGFLPEDDVPHLLGLGWNWASWRQSPPRAALRPAVSSSDQQSLIRKLQKRGSPSDVVTPIV
201211221231241251261271281291
TQHSKVNDSNELGGLTTSGSAEVHKAITISSPLTTDLTAELSGGPKNVSVQPEISEGLATTPSTQQVKSSEKTQIAVPQPVAPSYSYATPTPQASFQSTS
301311321331341351361371381391
APYPVIKELVVSAGESVQITLPKNEVQLNAYVLQEPPKGETYTYDWQLITHPRDYSGEMEGKHSQILKLSKLTPGLYEFKVIVEGQNAHGEGYVNVTVKP
401411421431441451461471481491
EPRKNRPPIAIVSPQFQEISLPTTSTVIDGSQSTDDDKIVQYHWEELKGPLREEKISEDTAILKLSKLVPGNYTFSLTVVDSDGATNSTTANLTVNKAVD
501511521531541551561571581591
YPPVANAGPNQVITLPQNSITLFGNQSTDDHGITSYEWSLSPSSKGKVVEMQGVRTPTLQLSAMQEGDYTYQLTVTDTIGQQATAQVTVIVQPENNKPPQ
601611621631641651661671681691
ADAGPDKELTLPVDSTTLDGSKSSDDQKIISYLWEKTQGPDGVQLENANSSVATVTGLQVGTYVFTLTVKDERNLQSQSSVNVIVKEEINKPPIAKITGN
701711721731741751761771781791
VVITLPTSTAELDGSKSSDDKGIVSYLWTRDEGSPAAGEVLNHSDHHPILFLSNLVEGTYTFHLKVTDAKGESDTDRTTVEVKPDPRKNNLVEIILDINV
801811821831841851861871881891
SQLTERLKGMFIRQIGVLLGVLDSDIIVQKIQPYTEQSTKMVFFVQNEPPHQIFKGHEVAAMLKSELRKQKADFLIFRALEVNTVTCQLNCSDHGHCDSF
901911921931941951961971981991
TKRCICDPFWMENFIKVQLRDGDSNCEWSVLYVIIATFVIVVALGILSWTVICCCKRQKGKPKRKSKYKILDATDQESLELKPTSRAGIKQKGLLLSSSL
10011011102110311041
MHSESELDSDDAIFTWPDREKGKLLHGQNGSVPNGQTPLKARSPREEIL

Reference

ID Publication
1Sun S, Shah P, Eshghi ST, Yang W, Trikannad N, Yang S, Chen L, Aiyetan P, Hoti N, Zhang Z, et al: Comprehensive analysis of protein glycosylation by solid-phase extraction of N-linked glycans and glycosite-containing peptides. Nat Biotech 2015, advance online publication.
2Shah P, Wang X, Yang W, Eshghi ST, Sun S, Hoti N, Chen L, Yang S, Pasay J, Rubin A: Integrated Proteomic and Glycoproteomic Analyses of Prostate Cancer Cells Reveal Glycoprotein Alteration in Protein Abundance and Glycosylation. Molecular & Cellular Proteomics 2015, 14:2753-2763.
12Weng Y, Sui Z, Jiang H, Shan Y, Chen L, Zhang S, Zhang L, Zhang Y: Releasing N-glycan from Peptide N-terminus by N-terminal Succinylation Assisted Enzymatic Deglycosylation. Scientific Reports 2015, 5.
14Liu Y, Chen J, Sethi A, Li QK, Chen L, Collins B, Gillet LC, Wollscheid B, Zhang H, Aebersold R: Glycoproteomic analysis of prostate cancer tissues by SWATH mass spectrometry discovers N-acylethanolamine acid amidase and protein tyrosine kinase 7 as signatures for tumor aggressiveness. Molecular & Cellular Proteomics 2014, 13:1753-1768.
16Deeb SJ, Cox J, Schmidt-Supprian M, Mann M: N-linked Glycosylation Enrichment for In-depth Cell Surface Proteomics of Diffuse Large B-cell Lymphoma Subtypes. Molecular & Cellular Proteomics 2014, 13:240-251.
32Zhang Z, Sun Z, Zhu J, Liu J, Huang G, Ye M, Zou H: High-Throughput Determination of the Site-Specific N-Sialoglycan Occupancy Rates by Differential Oxidation of Glycoproteins Followed with Quantitative Glycoproteomics Analysis. Analytical Chemistry 2014, 86:9830-9837.
33Zhu J, Sun Z, Cheng K, Chen R, Ye M, Xu B, Sun D, Wang L, Liu J, Wang F, Zou H: Comprehensive Mapping of Protein N-Glycosylation in Human Liver by Combining Hydrophilic Interaction Chromatography and Hydrazide Chemistry. Journal of Proteome Research 2014, 13:1713-1721.
48Danzer C, Eckhardt K, Schmidt A, Fankhauser N, Ribrioux S, Wollscheid B, Mueller L, Schiess R, Zuellig R, Lehmann R, et al: Comprehensive Description of the N-Glycoproteome of Mouse Pancreatic beta-Cells and Human Islets. Journal of Proteome Research 2012, 11:1598-1608.
52Yen T-Y, Macher BA, McDonald CA, Alleyne-Chin C, Timpe LC: Glycoprotein Profiles of Human Breast Cells Demonstrate a Clear Clustering of Normal/Benign versus Malignant Cell Lines and Basal versus Luminal Cell Lines. Journal of Proteome Research 2012, 11:656-667.
58Nagano K, Shinkawa T, Kato K, Inomata N, Yabuki N, Haramura M: Distinct cell surface proteome profiling by biotin labeling and glycoprotein capturing. Journal of Proteomics 2011, 74:1985-1993.
64Chen R, Jiang X, Sun D, Han G, Wang F, Ye M, Wang L, Zou H: Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry. J Proteome Res 2009, 8:651-661.