Contains      

UniProtKB-Q8TB96

Protein T-cell immunomodulatory protein
Gene ITFG1
Status Reviewed
Source Breast cancer cell lines; Breast cancer xenografts; Breast cell lines; Breast tumor; HEK293T cell line (embryonic kidney); LNCap/PC3 cell lines (Prostate cancer); Liver; OVCAR-3 cell line (Ovarian cancer); Ovarian tumor; Pancreatic islets; Prostate tumor; Urine
Years 2007-2015

Glycosites

Site Identified Peptides Year(Publication ID)
36 LHnVTAELF 2014(33);
36 LHnVTAELFGAEAWGTLAAFGDLNSDK 2015(unpublished);
95 nHSALITSVVPGDYDGDSQMDVLLTYLPK 2011(57); 2012(52); 2015(unpublished);2015(2);
95 VSFKnHSALITSVVPGDYDGDSQMDVLLTYLPK 2015(1); 2015(2);
139 SELGAVIFWGQnQTLDPNNMTILNR 2012(52);
146 SELGAVIFWGQNQTLDPNnMTILNR 2012(52);
151 SELGAVIFWGQNQTLDPNNMTILnR 2012(52);
176 IFGITnE 2014(33);
176 GITnESNQPQIL 2014(33);
176 nESNQPQILLGG 2015(1);
176 TFQDEPLIMDFNGDLIPDIFGITnESNQPQILLGGNLSWHPALTTTSK 2015(1);
188 LGGnLSWHPAL 2009(64);
188 LGGnLSWHPALT 2014(33);
188 LGGnLSWHPALTTT 2014(33);
188 LGGnLSWHPALTTTSK 2007(unpublished);2007(unpublished);2007;
188 TFQDEPLIMDFNGDLIPDIFGITNESNQPQILLGGnLSWHPALTTTSK 2015(1);
226 LTTLnATTSTF 2014(33);
226 LFLTTLnATTSTF 2014(33);
353 nTSGSNQQAFLLE 2014(33);
353 VILKnTSGSNQQAF 2014(33);
353 nTSGSNQQAFLLENVPCNNASCEEAR 2012(52); 2015(unpublished);2015(unpublished);2015(unpublished);
353 nTSGSNQQAFLLENVPCNNASCEEARR 2012(52);
371 nASCEEAR 2015(1);
371 nASCEEARR 2015(1);
371 PCNnASCEEAR 2012(48);
371 LLENVPCNnASCEEAR 2007(48); 2012(unpublished);2007(unpublished);2007(unpublished);2007(unpublished);2007(unpublished);2007;
371 NTSGSNQQAFLLENVPCNnASCEEAR 2012(52); 2015(unpublished);2015(unpublished);2015(unpublished);
371 NTSGSNQQAFLLENVPCNnASCEEARR 2012(52);
482 LKnGSAGQL 2014(33);
482 LKnGSAGQLSQSAHL 2014(33);
482 TTVDANGYLKnGSAGQL 2014(33);
482 nGSAGQLSQSAHLALQLPYNVLGLGR 2013(45);

Sequence

1112131415161718191
MAAAGRLPSSWALFSPLLAGLALLGVGPVPARALHNVTAELFGAEAWGTLAAFGDLNSDKQTDLFVLRERNDLIVFLADQNAPYFKPKVKVSFKNHSALI
101111121131141151161171181191
TSVVPGDYDGDSQMDVLLTYLPKNYAKSELGAVIFWGQNQTLDPNNMTILNRTFQDEPLIMDFNGDLIPDIFGITNESNQPQILLGGNLSWHPALTTTSK
201211221231241251261271281291
MRIPHSHAFIDLTEDFTADLFLTTLNATTSTFQFEIWENLDGNFSVSTILEKPQNMMVVGQSAFADFDGDGHMDHLLPGCEDKNCQKSTIYLVRSGMKQW
301311321331341351361371381391
VPVLQDFSNKGTLWGFVPFVDEQQPTEIPIPITLHIGDYNMDGYPDALVILKNTSGSNQQAFLLENVPCNNASCEEARRMFKVYWELTDLNQIKDAMVAT
401411421431441451461471481491
FFDIYEDGILDIVVLSKGYTKNDFAIHTLKNNFEADAYFVKVIVLSGLCSNDCPRKITPFGVNQPGPYIMYTTVDANGYLKNGSAGQLSQSAHLALQLPY
501511521531541551561571581591
NVLGLGRSANFLDHLYVGIPRPSGEKSIRKQEWTAIIPNSQLIVIPYPHNVPRSWSAKLYLTPSNIVLLTAIALIGVCVFILAIIGILHWQEKKADDREK
601611
RQEAHRFHFDAM

Reference

ID Publication
1Sun S, Shah P, Eshghi ST, Yang W, Trikannad N, Yang S, Chen L, Aiyetan P, Hoti N, Zhang Z, et al: Comprehensive analysis of protein glycosylation by solid-phase extraction of N-linked glycans and glycosite-containing peptides. Nat Biotech 2015, advance online publication.
2Shah P, Wang X, Yang W, Eshghi ST, Sun S, Hoti N, Chen L, Yang S, Pasay J, Rubin A: Integrated Proteomic and Glycoproteomic Analyses of Prostate Cancer Cells Reveal Glycoprotein Alteration in Protein Abundance and Glycosylation. Molecular & Cellular Proteomics 2015, 14:2753-2763.
33Zhu J, Sun Z, Cheng K, Chen R, Ye M, Xu B, Sun D, Wang L, Liu J, Wang F, Zou H: Comprehensive Mapping of Protein N-Glycosylation in Human Liver by Combining Hydrophilic Interaction Chromatography and Hydrazide Chemistry. Journal of Proteome Research 2014, 13:1713-1721.
45Zhou H, Froehlich JW, Briscoe AC, Lee RS: The GlycoFilter: A Simple and Comprehensive Sample Preparation Platform for Proteomics, N-Glycomics and Glycosylation Site Assignment. Molecular & Cellular Proteomics 2013, 12:2981-2991.
48Danzer C, Eckhardt K, Schmidt A, Fankhauser N, Ribrioux S, Wollscheid B, Mueller L, Schiess R, Zuellig R, Lehmann R, et al: Comprehensive Description of the N-Glycoproteome of Mouse Pancreatic beta-Cells and Human Islets. Journal of Proteome Research 2012, 11:1598-1608.
52Yen T-Y, Macher BA, McDonald CA, Alleyne-Chin C, Timpe LC: Glycoprotein Profiles of Human Breast Cells Demonstrate a Clear Clustering of Normal/Benign versus Malignant Cell Lines and Basal versus Luminal Cell Lines. Journal of Proteome Research 2012, 11:656-667.
57Chen Y, Cao J, Yan G, Lu H, Yang P: Two-step protease digestion and glycopeptide capture approach for accurate glycosite identification and glycoprotein sequence coverage improvement. Talanta 2011, 85:70-75.
64Chen R, Jiang X, Sun D, Han G, Wang F, Ye M, Wang L, Zou H: Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry. J Proteome Res 2009, 8:651-661.