| Protein | Scavenger receptor class B member 1 |
| Gene | SCARB1 |
| Status | Reviewed |
| Source | 22Rv1 cell line (prostate cancer); Breast cancer cell lines; Breast cancer xenografts; Breast cell lines; Breast tumor; Colorectal cancer cell line, HCT-116 (colorectal cancer); DLBCL cell lines (Diffuse large B-cell lymphoma); HCC cell lines (Liver); HEK293T cell line (embryonic kidney); Hela cell line (cervical cancer); K562A cell line (Leukemia); K562S cell line (Leukemia); LNCap/PC3 cell lines (Prostate cancer); Liver; Liver tumor (HCC); Lymphocytes; OVCAR-3 cell line (Ovarian cancer); Ovarian tumor; Pancreatic islets; Prostate; Prostate tumor |
| Years | 2007-2015 |
| Site | Identified Peptides | Year(Publication ID) |
|---|---|---|
| 102 | SnITFNNNDTVSFL | 2014(33); |
| 102 | SnITFNNNDTVSFLE | 2014(33); |
| 102 | RHKSnITFNNNDTVSF | 2014(33); |
| 102 | FRHKSnITFNNNDTVSF | 2009(64); |
| 102 | RHKSnITFNNNDTVSFL | 2014(33); |
| 102 | SnITFNNNDTVSFIEYR | 2014(32); 2014(32); |
| 102 | SnITFNNNDTVSFLEYR | 2011(58); 2012(50); 2012(52); 2014(33); 2015(2); 2015(unpublished);2015(unpublished);2007(unpublished);2007(unpublished);2007;2007; |
| 102 | HKSnITFNNNDTVSFIEYR | 2014(16); |
| 102 | HKSnITFNNNDTVSFLEYR | 2011(58); 2012(52); 2014(33); 2015(2); 2015(12); |
| 102 | RHKSnITFNNNDTVSFLEY | 2014(33); |
| 108 | NNnDTVSFL | 2014(33); |
| 108 | nDTVSFLEYR | 2014(33); |
| 108 | FNNnDTVSFLE | 2014(33); |
| 108 | NnDTVSFLEYR | 2014(33); |
| 108 | NNnDTVSFLEY | 2014(33); |
| 108 | NNnDTVSFLEYR | 2014(33); |
| 108 | SNITFNNnDTVSFL | 2014(33); |
| 108 | SNITFNNnDTVSFLE | 2014(33); |
| 108 | RHKSNITFNNnDTVSF | 2014(33); |
| 108 | FRHKSNITFNNnDTVSF | 2009(64); |
| 108 | RHKSNITFNNnDTVSFL | 2014(33); |
| 108 | SNITFNNnDTVSFIEYR | 2014(32); 2014(32); |
| 108 | SNITFNNnDTVSFLEYR | 2011(58); 2012(50); 2012(52); 2014(33); 2015(2); 2015(unpublished);2015(unpublished);2007(unpublished);2007(unpublished);2007;2007; |
| 108 | HKSNITFNNnDTVSFIEYR | 2014(16); |
| 108 | HKSNITFNNnDTVSFLEYR | 2011(58); 2012(52); 2014(33); 2015(2); 2015(12); |
| 108 | RHKSNITFNNnDTVSFLEY | 2014(33); |
| 173 | nRTVGEIMW | 2014(33); |
| 173 | MnRTVGEIMW | 2014(33); |
| 212 | LnNSDSGLF | 2014(33); |
| 212 | AELnNSDSGLF | 2014(33); |
| 212 | AELnNSDSGLFTVF | 2014(33); |
| 212 | GLFAELnNSDSGLF | 2014(33); |
| 212 | FGLFAELnNSDSGLF | 2011(57); |
| 212 | nNSDSGLFTVFTGVQ | 2015(1); |
| 212 | LnNSDSGLFTVFTGVQNISR | 2014(33); |
| 212 | FGLFAELnNSDSGLFTVFTGVQNISR | 2015(2); |
| 212 | DKFGLFAELnNSDSGLFTVFTGVQNISR | 2015(2); |
| 227 | TGVQnISR | 2011(57); 2014(14); 2014(33); |
| 227 | TGVQnISRIH | 2014(33); |
| 227 | TGVQnISRIHL | 2014(33); |
| 227 | TVFTGVQnISR | 2011(57); 2014(33); |
| 227 | LNNSDSGLFTVFTGVQnISR | 2014(33); |
| 227 | FGLFAELNNSDSGLFTVFTGVQnISR | 2015(2); |
| 227 | DKFGLFAELNNSDSGLFTVFTGVQnISR | 2015(2); |
| 255 | HSDQCNMInGTSGQ | 2014(33); |
| 255 | VDFWHSDQCNMInGTSGQ | 2014(33); |
| 255 | HSDQCNMInGTSGQMWPPFM | 2014(33); |
| 255 | HSDQCNMInGTSGQMWPPFMTPESSL | 2014(33); |
| 255 | HSDQCNMInGTSGQMWPPFMTPESSLEF | 2014(33); |
| 255 | VDFWHSDQCNMInGTSGQMWPPFMTPESSLEFYSPEACR | 2015(12); |
| 310 | AnGSIYPPNEGF | 2014(33); |
| 310 | FAnGSIYPPNEGF | 2014(33); |
| 310 | TLFAnGSIYPPNE | 2014(33); |
| 310 | VAPKTLFAnGSIYPPNEGF | 2014(33); |
| 310 | nGSIYPPNEGFCPCLESGIQ | 2015(1); |
| 310 | TLFAnGSIYPPNEGFCPCLE | 2014(33); |
| 310 | TIFAnGSIYPPNEGFCPCIESGIQNVSTCR | 2014(32); |
| 310 | TLFAnGSIYPPNEGFCPCLESGIQNVSTCR | 2011(58); 2012(52); 2013(40); 2014(25); 2014(25); 2014(33); 2015(12); 2007(unpublished);2007(unpublished);2007(unpublished); |
| 330 | GIQnVSTCR | 2014(33); |
| 330 | SGIQnVSTCR | 2014(33); |
| 330 | ESGIQnVSTCR | 2012(48); |
| 330 | SGIQnVSTCRF | 2014(33); |
| 330 | ESGIQnVSTCRF | 2009(64); |
| 330 | CPCLESGIQnVSTC | 2014(33); |
| 330 | CPCLESGIQnVSTCR | 2014(33); |
| 330 | TIFANGSIYPPNEGFCPCIESGIQnVSTCR | 2014(32); |
| 330 | TLFANGSIYPPNEGFCPCLESGIQnVSTCR | 2011(58); 2012(52); 2013(40); 2014(25); 2014(25); 2014(33); 2015(12); 2007(unpublished);2007(unpublished);2007(unpublished); |
| 383 | nCSVKL | 2014(33); |
| 383 | LDIHPVTGIPMnC | 2014(33); |
| 383 | IHPVTGIPMnCSVK | 2014(33); |
| 383 | DIHPVTGIPMnCSVK | 2014(33); |
| 383 | LDIHPVTGIPMnCSVK | 2014(33); |
| 383 | LDIHPVTGIPMnCSVKL | 2014(33); |
| 383 | AHSLFLDIHPVTGIPMnCSVK | 2014(33); |
| 1 | 11 | 21 | 31 | 41 | 51 | 61 | 71 | 81 | 91 |
| MGCSAKARWA | AGALGVAGLL | CAVLGAVMIV | MVPSLIKQQV | LKNVRIDPSS | LSFNMWKEIP | IPFYLSVYFF | DVMNPSEILK | GEKPQVRERG | PYVYREFRHK |
| 101 | 111 | 121 | 131 | 141 | 151 | 161 | 171 | 181 | 191 |
| SNITFNNNDT | VSFLEYRTFQ | FQPSKSHGSE | SDYIVMPNIL | VLGAAVMMEN | KPMTLKLIMT | LAFTTLGERA | FMNRTVGEIM | WGYKDPLVNL | INKYFPGMFP |
| 201 | 211 | 221 | 231 | 241 | 251 | 261 | 271 | 281 | 291 |
| FKDKFGLFAE | LNNSDSGLFT | VFTGVQNISR | IHLVDKWNGL | SKVDFWHSDQ | CNMINGTSGQ | MWPPFMTPES | SLEFYSPEAC | RSMKLMYKES | GVFEGIPTYR |
| 301 | 311 | 321 | 331 | 341 | 351 | 361 | 371 | 381 | 391 |
| FVAPKTLFAN | GSIYPPNEGF | CPCLESGIQN | VSTCRFSAPL | FLSHPHFLNA | DPVLAEAVTG | LHPNQEAHSL | FLDIHPVTGI | PMNCSVKLQL | SLYMKSVAGI |
| 401 | 411 | 421 | 431 | 441 | 451 | 461 | 471 | 481 | 491 |
| GQTGKIEPVV | LPLLWFAESG | AMEGETLHTF | YTQLVLMPKV | MHYAQYVLLA | LGCVLLLVPV | ICQIRSQVGA | GQRAARADSH | SLACWGKGAS | DRTLWPTAAW |
| 501 | 511 | 521 | 531 | 541 | 551 | ||||
| SPPPAAVLRL | CRSGSGHCWG | LRSTLASFAC | RVATTLPVLE | GLGPSLGGGT | GS |
| ID | Publication |
|---|---|
| 1 | Sun S, Shah P, Eshghi ST, Yang W, Trikannad N, Yang S, Chen L, Aiyetan P, Hoti N, Zhang Z, et al: Comprehensive analysis of protein glycosylation by solid-phase extraction of N-linked glycans and glycosite-containing peptides. Nat Biotech 2015, advance online publication. |
| 2 | Shah P, Wang X, Yang W, Eshghi ST, Sun S, Hoti N, Chen L, Yang S, Pasay J, Rubin A: Integrated Proteomic and Glycoproteomic Analyses of Prostate Cancer Cells Reveal Glycoprotein Alteration in Protein Abundance and Glycosylation. Molecular & Cellular Proteomics 2015, 14:2753-2763. |
| 12 | Weng Y, Sui Z, Jiang H, Shan Y, Chen L, Zhang S, Zhang L, Zhang Y: Releasing N-glycan from Peptide N-terminus by N-terminal Succinylation Assisted Enzymatic Deglycosylation. Scientific Reports 2015, 5. |
| 14 | Liu Y, Chen J, Sethi A, Li QK, Chen L, Collins B, Gillet LC, Wollscheid B, Zhang H, Aebersold R: Glycoproteomic analysis of prostate cancer tissues by SWATH mass spectrometry discovers N-acylethanolamine acid amidase and protein tyrosine kinase 7 as signatures for tumor aggressiveness. Molecular & Cellular Proteomics 2014, 13:1753-1768. |
| 16 | Deeb SJ, Cox J, Schmidt-Supprian M, Mann M: N-linked Glycosylation Enrichment for In-depth Cell Surface Proteomics of Diffuse Large B-cell Lymphoma Subtypes. Molecular & Cellular Proteomics 2014, 13:240-251. |
| 25 | Sun Z, Dong J, Zhang S, Hu Z, Cheng K, Li K, Xu B, Ye M, Nie Y, Fan D, Zou H: Identification of Chemoresistance-Related Cell-Surface Glycoproteins in Leukemia Cells and Functional Validation of Candidate Glycoproteins. Journal of Proteome Research 2014, 13:1593-1601. |
| 32 | Zhang Z, Sun Z, Zhu J, Liu J, Huang G, Ye M, Zou H: High-Throughput Determination of the Site-Specific N-Sialoglycan Occupancy Rates by Differential Oxidation of Glycoproteins Followed with Quantitative Glycoproteomics Analysis. Analytical Chemistry 2014, 86:9830-9837. |
| 33 | Zhu J, Sun Z, Cheng K, Chen R, Ye M, Xu B, Sun D, Wang L, Liu J, Wang F, Zou H: Comprehensive Mapping of Protein N-Glycosylation in Human Liver by Combining Hydrophilic Interaction Chromatography and Hydrazide Chemistry. Journal of Proteome Research 2014, 13:1713-1721. |
| 40 | Li X, Jiang J, Zhao X, Wang J, Han H, Zhao Y, Peng B, Zhong R, Ying W, Qian X: N-glycoproteome Analysis of the Secretome of Human Metastatic Hepatocellular Carcinoma Cell Lines Combining Hydrazide Chemistry, HILIC Enrichment and Mass Spectrometry. Plos One 2013, 8. |
| 48 | Danzer C, Eckhardt K, Schmidt A, Fankhauser N, Ribrioux S, Wollscheid B, Mueller L, Schiess R, Zuellig R, Lehmann R, et al: Comprehensive Description of the N-Glycoproteome of Mouse Pancreatic beta-Cells and Human Islets. Journal of Proteome Research 2012, 11:1598-1608. |
| 50 | Whitmore TE, Peterson A, Holzman T, Eastham A, Amon L, McIntosh M, Ozinsky A, Nelson PS, Martin DB: Integrative Analysis of N-Linked Human Glycoproteomic Data Sets Reveals PTPRF Ectodomain as a Novel Plasma Biomarker Candidate for Prostate Cancer. Journal of Proteome Research 2012, 11:2653-2665. |
| 52 | Yen T-Y, Macher BA, McDonald CA, Alleyne-Chin C, Timpe LC: Glycoprotein Profiles of Human Breast Cells Demonstrate a Clear Clustering of Normal/Benign versus Malignant Cell Lines and Basal versus Luminal Cell Lines. Journal of Proteome Research 2012, 11:656-667. |
| 57 | Chen Y, Cao J, Yan G, Lu H, Yang P: Two-step protease digestion and glycopeptide capture approach for accurate glycosite identification and glycoprotein sequence coverage improvement. Talanta 2011, 85:70-75. |
| 58 | Nagano K, Shinkawa T, Kato K, Inomata N, Yabuki N, Haramura M: Distinct cell surface proteome profiling by biotin labeling and glycoprotein capturing. Journal of Proteomics 2011, 74:1985-1993. |
| 64 | Chen R, Jiang X, Sun D, Han G, Wang F, Ye M, Wang L, Zou H: Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry. J Proteome Res 2009, 8:651-661. |