Contains      

UniProtKB-Q92673

Protein Sortilin-related receptor
Gene SORL1
Status Reviewed
Source Bladder tumor; Breast Cancer cell lines; Breast cancer cell lines; Breast cancer xenografts; Breast cell lines; Breast cell linesJurkat T cell line; Breast tumor; Cerebrospinal fluid; Colorectal tumor; DLBCL cell lines (Diffuse large B-cell lymphoma); HCC cell lines (Liver); HEK293 cell line (embryonic kidney); HEK293T cell line (embryonic kidney), HEK293T cell line (embryonic kidney); Hela cell line (cervical cancer); HuH-7 cell line (Liver)Jurkat T cell line; IGROV-1/CP cell line (Ovarian cancer)IGROV-1/CP; Jurkat T cell line; LNCap/PC3 cell lines (Prostate cancer); Liver; Liver tumor (HCC); Non-small Cell Lung Carcinoma; OVCAR-3 cell line (Ovarian cancer); Ovarian cancer cell lines; Ovarian tumor; Pancreatic islets; Prostate; Prostate cancer metastasis to liver; Prostate tumor; Saliva; Serum; Urine; UrineJurkat T cell line; ovarian tumor
Years 2007-2015

Glycosites

Site Identified Peptides Year(Publication ID)
99 nDSHNQMVVHWAGEK 2015(1);
99 GQVSLnDSHNQMVVHW 2014(33);
99 VYGQVSLnDSHNQMVVH 2012(48); 2015(unpublished);
99 GQVSLnDSHNQMVVHWAGEK 2014(33);
99 VYGQVSInDSHNQMVVHWAGEK 2014(16);
99 VYGQVSLnDSHNQMVVHWAGEK 2007(64); 2009(48); 2012(33); 2014(1); 2015(2); 2015(unpublished);2015(unpublished);2015;2015;2015;2007;2007;
99 SAAIQPEPIKVYGQVSInDSHNQMVVHWAGEK 2014(16);
158 LNFGLGnR 2007(13); 2014(33); 2014(1); 2015(unpublished);2015(unpublished);2015;2015;2015;2007;2007;
158 ISDKINFGIGnR 2014(16);
158 ISDKLNFGLGnR 2014(33); 2015(1); 2015(unpublished);2015(unpublished);2015(unpublished);
158 GLGnRSEAVIAQF 2014(33);
158 INFGIGnRSEAVI 2013(37);
158 KISDKLNFGLGnR 2014(33);
158 GLGnRSEAVIAQFY 2014(33);
368 VCVSHSNnRTNL 2014(33);
368 DQVFVCVSHSNnR 2014(33);
368 VCVSHSNnRTNLY 2014(33);
368 HPINEYYIADASEDQVFVCVSHSNnR 2014(16);
430 nGSMNEENMR 2015(1);
430 TLInGSMNEENMR 2014(14);
430 IATLInGSMNEENMR 2012(48); 2014(33);
430 VEGIQGVYIATIInGSMNEENMR 2014(16); 2014(32); 2014(32);
430 VEGLQGVYIATLInGSMNEENMR 2012(48); 2012(52); 2014(33); 2015(unpublished);2015(1); 2015(unpublished);
430 YFANEPFADFHRVEGLQGVYIATLInGSMNEENMR 2012(52); 2015(2);
616 nATDALGVPCTENDYK 2015(1);
616 ENVHSWLILQVnATDALGVPCTENDYK 2015(unpublished);2015(1);
674 RPVVVSnCSCTRE 2013(37);
674 NGEDFDRPVVVSnCSCTR 2014(33);
674 ATCFNGEDFDRPVVVSnCSCTR 2012(48);
674 TPHATCFNGEDFDRPVVVSnCSCTR 2013(45); 2014(16); 2014(33);
674 TPHATCFNGEDFDRPVVVSnCSCTRE 2014(33);
871 nSSVLDRPR 2012(48); 2015(1);
871 RLTIVnSSVL 2014(33);
871 VnSSVLDRPR 2012(48);
871 IVnSSVLDRPR 2012(48);
871 TIVnSSVLDRPR 2012(48);
871 FRITIVnSSVIDR 2013(37);
871 ITIVnSSVIDRPR 2014(16);
871 LTIVnSSVLDRPR 2007(56); 2011(48); 2012(52); 2012(45); 2013(13); 2014(22); 2014(33); 2014(1); 2015(2); 2015(12); 2015(unpublished);2015(unpublished);2015(unpublished);2015(unpublished);2015(unpublished);2015;2007;2007;2007;2007;2007;
1068 nNTCVK 2015(1);
1068 nNTCVKQENTCLR 2014(33);
1068 QLKnNTCVKQENTCL 2014(33);
1068 CPEDVSSSVIPSGDIMCDCPQGYQIKnNTCVK 2014(16);
1164 nCSSGMCIR 2015(1);
1164 YnCSSGMCIR 2014(33);
1164 CRSDEYnCSSGMC 2013(37);
1164 SDEYnCSSGMCIR 2012(52); 2014(13); 2014(16); 2014(18); 2014(22); 2014(33); 2015(12); 2015(unpublished);2015(unpublished);2015;2007;2007;
1191 AnCTAIYHTCE 2014(33);
1191 nCTAIYHTCEASNFQCR 2015(1);
1191 DWSDEAnCTAIYHTCEASNFQCR 2014(16);
1191 SSWVCDGDNDCRDWSDEAnCTAIYHTCEASNFQCR 2014(16);
1246 CPnGTCIPSSK 2014(16); 2014(33); 2015(unpublished);2015(12);
1246 NGFRCPnGTCIPS 2013(37);
1458 LAnVTAASTPTQL 2014(33);
1458 nVTAASTPTQLGR 2015(1);
1458 ACPLLAnVTAASTPTQLGR 2014(33);
1458 DCADGSDEEACPLLAnVTAASTPTQLGR 2012(48); 2014(33); 2015(1);
1608 TIETHSnK 2014(16);
1608 TLETHSnK 2014(14); 2014(33); 2015(unpublished);2015(unpublished);
1608 THSnKTNTVLK 2014(33);
1608 KTLETHSnKTNTVL 2014(33);
1608 TIETHSnKTNTVIK 2014(16);
1608 TLETHSnKTNTVLK 2014(13); 2014(33); 2015(2);
1706 AASnFTEIK 2007(48); 2012(34); 2013(38); 2013(13); 2014(14); 2014(15); 2014(16); 2014(18); 2014(22); 2014(32); 2014(33); 2014(1); 2015(2); 2015(12); 2015(unpublished);2015(unpublished);2015(unpublished);2015;2015;2015;2007;2007;2007;
1706 SQRAASnFTEIKN 2013(37);
1706 AASnFTEIKNLLVNTLYTVR 2014(33); 2015(2);
1733 GIGnWSDSK 2012(48); 2012(52); 2014(13); 2014(15); 2014(16); 2014(18); 2014(22); 2014(32); 2014(32); 2014(33); 2015(unpublished);2015(1); 2015(2); 2015(unpublished);2015(unpublished);2015(unpublished);2015(unpublished);2015(12);
1733 IGnWSDSKS 2009(64);
1733 TSRGIGnWSDSKS 2013(37);
1809 VGnLTAH 2014(33); 2015(unpublished);
1809 SHKVGnLTAH 2014(33);
1809 VGnLTAHTSY 2014(33);
1809 VGnLTAHTSYE 2014(33);
1809 SHKVGnLTAHTSY 2014(33);
1809 VGnITAHTSYEISAWAK 2014(16);
1809 VGnLTAHTSYEISAWAK 2014(33); 2015(unpublished);
1854 IKAKAInQTAVEC 2013(37);
1854 KAKAInQTAVECTW 2014(33);
1854 AInQTAVECTWTGPR 2007(75); 2011(54); 2012(52); 2014(13); 2014(15); 2014(16); 2014(17); 2014(18); 2014(22); 2014(32); 2014(33); 2015(1); 2015(12); 2015(unpublished);2015(unpublished);2007(unpublished);2007(unpublished);2007(unpublished);2007(Unpublished ); 2007;2007 ;
1894 SITTSIHnK 2014(16);
1894 SLTTSLHnK 2014(13); 2014(15); 2014(22); 2014(33); 2015(unpublished);2015(unpublished);
1894 HnKTVIVSKDEQY 2014(33);
1894 ITTSIHnKTVIVS 2013(37);
1894 TTSLHnKTVIVSKDEQY 2014(33);
1986 SRnSTVEY 2014(33);
1986 nSTVEYTLNK 2013(40); 2014(14); 2014(33); 2015(2); 2015(unpublished);2015(Unpublished ); 2015;2007;2007 ;
1986 SRnSTVEYTLNK 2014(13); 2015(1); 2015(unpublished);2015(unpublished);2015(unpublished);2015(9);
1986 YKVKSRnSTVEYT 2013(37);
1986 SRnSTVEYTINKIEPGGK 2014(16);
1986 SRnSTVEYTLNKLEPGGK 2014(13); 2015(2);
2010 HIIVQLGnMSK 2014(33);
2010 YHIIVQIGnMSK 2014(16);
2010 YHIIVQLGnMSK 2007(64); 2009(48); 2012(33); 2014(1); 2015(2); 2015(unpublished);2015(unpublished);2015;2015;2015;2015;2007;2007;
2054 HFnESR 2013(40); 2014(22);
2054 EKHFnESR 2015(unpublished);
2054 ALKEKHFnESRGY 2014(33);
2054 SIAIKEKHFnESR 2014(16);
2069 IHMFDSAMnITAY 2014(33);
2069 EIHMFDSAMnITAY 2014(33);
2069 GYEIHMFDSAMnITAY 2014(33);

Sequence

1112131415161718191
MATRSSRRESRLPFLFTLVALLPPGALCEVWTQRLHGGSAPLPQDRGFLVVQGDPRELRLWARGDARGASRADEKPLRRKRSAALQPEPIKVYGQVSLND
101111121131141151161171181191
SHNQMVVHWAGEKSNVIVALARDSLALARPKSSDVYVSYDYGKSFKKISDKLNFGLGNRSEAVIAQFYHSPADNKRYIFADAYAQYLWITFDFCNTLQGF
201211221231241251261271281291
SIPFRAADLLLHSKASNLLLGFDRSHPNKQLWKSDDFGQTWIMIQEHVKSFSWGIDPYDKPNTIYIERHEPSGYSTVFRSTDFFQSRENQEVILEEVRDF
301311321331341351361371381391
QLRDKYMFATKVVHLLGSEQQSSVQLWVSFGRKPMRAAQFVTRHPINEYYIADASEDQVFVCVSHSNNRTNLYISEAEGLKFSLSLENVLYYSPGGAGSD
401411421431441451461471481491
TLVRYFANEPFADFHRVEGLQGVYIATLINGSMNEENMRSVITFDKGGTWEFLQAPAFTGYGEKINCELSQGCSLHLAQRLSQLLNLQLRRMPILSKESA
501511521531541551561571581591
PGLIIATGSVGKNLASKTNVYISSSAGARWREALPGPHYYTWGDHGGIITAIAQGMETNELKYSTNEGETWKTFIFSEKPVFVYGLLTEPGEKSTVFTIF
601611621631641651661671681691
GSNKENVHSWLILQVNATDALGVPCTENDYKLWSPSDERGNECLLGHKTVFKRRTPHATCFNGEDFDRPVVVSNCSCTREDYECDFGFKMSEDLSLEVCV
701711721731741751761771781791
PDPEFSGKSYSPPVPCPVGSTYRRTRGYRKISGDTCSGGDVEARLEGELVPCPLAEENEFILYAVRKSIYRYDLASGATEQLPLTGLRAAVALDFDYEHN
801811821831841851861871881891
CLYWSDLALDVIQRLCLNGSTGQEVIINSGLETVEALAFEPLSQLLYWVDAGFKKIEVANPDGDFRLTIVNSSVLDRPRALVLVPQEGVMFWTDWGDLKP
901911921931941951961971981991
GIYRSNMDGSAAYHLVSEDVKWPNGISVDDQWIYWTDAYLECIERITFSGQQRSVILDNLPHPYAIAVFKNEIYWDDWSQLSIFRASKYSGSQMEILANQ
1001101110211031104110511061107110811091
LTGLMDMKIFYKGKNTGSNACVPRPCSLLCLPKANNSRSCRCPEDVSSSVLPSGDLMCDCPQGYQLKNNTCVKQENTCLRNQYRCSNGNCINSIWWCDFD
1101111111211131114111511161117111811191
NDCGDMSDERNCPTTICDLDTQFRCQESGTCIPLSYKCDLEDDCGDNSDESHCEMHQCRSDEYNCSSGMCIRSSWVCDGDNDCRDWSDEANCTAIYHTCE
1201121112211231124112511261127112811291
ASNFQCRNGHCIPQRWACDGDTDCQDGSDEDPVNCEKKCNGFRCPNGTCIPSSKHCDGLRDCSDGSDEQHCEPLCTHFMDFVCKNRQQCLFHSMVCDGII
1301131113211331134113511361137113811391
QCRDGSDEDAAFAGCSQDPEFHKVCDEFGFQCQNGVCISLIWKCDGMDDCGDYSDEANCENPTEAPNCSRYFQFRCENGHCIPNRWKCDRENDCGDWSDE
1401141114211431144114511461147114811491
KDCGDSHILPFSTPGPSTCLPNYYRCSSGTCVMDTWVCDGYRDCADGSDEEACPLLANVTAASTPTQLGRCDRFEFECHQPKTCIPNWKRCDGHQDCQDG
1501151115211531154115511561157115811591
RDEANCPTHSTLTCMSREFQCEDGEACIVLSERCDGFLDCSDESDEKACSDELTVYKVQNLQWTADFSGDVTLTWMRPKKMPSASCVYNVYYRVVGESIW
1601161116211631164116511661167116811691
KTLETHSNKTNTVLKVLKPDTTYQVKVQVQCLSKAHNTNDFVTLRTPEGLPDAPRNLQLSLPREAEGVIVGHWAPPIHTHGLIREYIVEYSRSGSKMWAS
1701171117211731174117511761177117811791
QRAASNFTEIKNLLVNTLYTVRVAAVTSRGIGNWSDSKSITTIKGKVIPPPDIHIDSYGENYLSFTLTMESDIKVNGYVVNLFWAFDTHKQERRTLNFRG
1801181118211831184118511861187118811891
SILSHKVGNLTAHTSYEISAWAKTDLGDSPLAFEHVMTRGVRPPAPSLKAKAINQTAVECTWTGPRNVVYGIFYATSFLDLYRNPKSLTTSLHNKTVIVS
1901191119211931194119511961197119811991
KDEQYLFLVRVVVPYQGPSSDYVVVKMIPDSRLPPRHLHVVHTGKTSVVIKWESPYDSPDQDLLYAVAVKDLIRKTDRSYKVKSRNSTVEYTLNKLEPGG
2001201120212031204120512061207120812091
KYHIIVQLGNMSKDSSIKITTVSLSAPDALKIITENDHVLLFWKSLALKEKHFNESRGYEIHMFDSAMNITAYLGNTTDNFFKISNLKMGHNYTFTVQAR
2101211121212131214121512161217121812191
CLFGNQICGEPAILLYDELGSGADASATQAARSTDVAAVVVPILFLILLSLGVGFAILYTKHRRLQSSFTAFANSHYSSRLGSAIFSSGDDLGEDDEDAP
22012211
MITGFSDDVPMVIA

Reference

ID Publication
1Sun S, Shah P, Eshghi ST, Yang W, Trikannad N, Yang S, Chen L, Aiyetan P, Hoti N, Zhang Z, et al: Comprehensive analysis of protein glycosylation by solid-phase extraction of N-linked glycans and glycosite-containing peptides. Nat Biotech 2015, advance online publication.
2Shah P, Wang X, Yang W, Eshghi ST, Sun S, Hoti N, Chen L, Yang S, Pasay J, Rubin A: Integrated Proteomic and Glycoproteomic Analyses of Prostate Cancer Cells Reveal Glycoprotein Alteration in Protein Abundance and Glycosylation. Molecular & Cellular Proteomics 2015, 14:2753-2763.
9Smeekens JM, Chen WX, Wu RH: Mass Spectrometric Analysis of the Cell Surface N-Glycoproteome by Combining Metabolic Labeling and Click Chemistry. Journal of the American Society for Mass Spectrometry 2015, 26:604-614.
12Weng Y, Sui Z, Jiang H, Shan Y, Chen L, Zhang S, Zhang L, Zhang Y: Releasing N-glycan from Peptide N-terminus by N-terminal Succinylation Assisted Enzymatic Deglycosylation. Scientific Reports 2015, 5.
13Yang W, Laeyendecker O, Wendel SK, Zhang B, Sun S, Zhou J-Y, Ao M, Moore RD, Jackson JB, Zhang H: Glycoproteomic Study Reveals Altered Plasma Proteins Associated with HIV Elite Suppressors. Theranostics 2014, 4:1153.
14Liu Y, Chen J, Sethi A, Li QK, Chen L, Collins B, Gillet LC, Wollscheid B, Zhang H, Aebersold R: Glycoproteomic analysis of prostate cancer tissues by SWATH mass spectrometry discovers N-acylethanolamine acid amidase and protein tyrosine kinase 7 as signatures for tumor aggressiveness. Molecular & Cellular Proteomics 2014, 13:1753-1768.
15Chen R, Seebun D, Ye M, Zou H, Figeys D: Site-specific characterization of cell membrane N-glycosylation with integrated hydrophilic interaction chromatography solid phase extraction and LC-MS/MS. Journal of Proteomics 2014, 103:194-203.
16Deeb SJ, Cox J, Schmidt-Supprian M, Mann M: N-linked Glycosylation Enrichment for In-depth Cell Surface Proteomics of Diffuse Large B-cell Lymphoma Subtypes. Molecular & Cellular Proteomics 2014, 13:240-251.
17Fang C, Xiong Z, Qin H, Huang G, Liu J, Ye M, Feng S, Zou H: One-pot synthesis of magnetic colloidal nanocrystal clusters coated with chitosan for selective enrichment of glycopeptides. Analytica Chimica Acta 2014, 841:99-105.
18Hirao Y, Matsuzaki H, Iwaki J, Kuno A, Kaji H, Ohkura T, Togayachi A, Abe M, Nomura M, Noguchi M, et al: Glycoproteomics Approach for Identifying Glycobiomarker Candidate Molecules for Tissue Type Classification of Non-small Cell Lung Carcinoma. Journal of Proteome Research 2014, 13:4705-4716.
22Nicastri A, Gaspari M, Sacco R, Elia L, Gabriele C, Romano R, Rizzuto A, Cuda G: N-Glycoprotein Analysis Discovers New Up-Regulated Glycoproteins in Colorectal Cancer Tissue. Journal of Proteome Research 2014, 13:4932-4941.
32Zhang Z, Sun Z, Zhu J, Liu J, Huang G, Ye M, Zou H: High-Throughput Determination of the Site-Specific N-Sialoglycan Occupancy Rates by Differential Oxidation of Glycoproteins Followed with Quantitative Glycoproteomics Analysis. Analytical Chemistry 2014, 86:9830-9837.
33Zhu J, Sun Z, Cheng K, Chen R, Ye M, Xu B, Sun D, Wang L, Liu J, Wang F, Zou H: Comprehensive Mapping of Protein N-Glycosylation in Human Liver by Combining Hydrophilic Interaction Chromatography and Hydrazide Chemistry. Journal of Proteome Research 2014, 13:1713-1721.
34Sun S, Zhang B, Aiyetan P, Zhou J-Y, Shah P, Yang W, Levine DA, Zhang Z, Chan DW, Zhang H: Analysis of N-glycoproteins using Genomic N-glycosite Prediction. Journal of Proteome Research 2013, 12:5609-5615.
37Boersema PJ, Geiger T, Wisniewski JR, Mann M: Quantification of the N-glycosylated Secretome by Super-SILAC During Breast Cancer Progression and in Human Blood Samples. Molecular & Cellular Proteomics 2013, 12:158-171.
38Kaji H, Ocho M, Togayachi A, Kuno A, Sogabe M, Ohkura T, Nozaki H, Angata T, Chiba Y, Ozaki H, et al: Glycoproteomic Discovery of Serological Biomarker Candidates for HCV/HBV Infection-Associated Liver Fibrosis and Hepatocellular Carcinoma. Journal of Proteome Research 2013, 12:2630-2640.
40Li X, Jiang J, Zhao X, Wang J, Han H, Zhao Y, Peng B, Zhong R, Ying W, Qian X: N-glycoproteome Analysis of the Secretome of Human Metastatic Hepatocellular Carcinoma Cell Lines Combining Hydrazide Chemistry, HILIC Enrichment and Mass Spectrometry. Plos One 2013, 8.
45Zhou H, Froehlich JW, Briscoe AC, Lee RS: The GlycoFilter: A Simple and Comprehensive Sample Preparation Platform for Proteomics, N-Glycomics and Glycosylation Site Assignment. Molecular & Cellular Proteomics 2013, 12:2981-2991.
48Danzer C, Eckhardt K, Schmidt A, Fankhauser N, Ribrioux S, Wollscheid B, Mueller L, Schiess R, Zuellig R, Lehmann R, et al: Comprehensive Description of the N-Glycoproteome of Mouse Pancreatic beta-Cells and Human Islets. Journal of Proteome Research 2012, 11:1598-1608.
52Yen T-Y, Macher BA, McDonald CA, Alleyne-Chin C, Timpe LC: Glycoprotein Profiles of Human Breast Cells Demonstrate a Clear Clustering of Normal/Benign versus Malignant Cell Lines and Basal versus Luminal Cell Lines. Journal of Proteome Research 2012, 11:656-667.
54Tian Y, Yao Z, Roden R, Zhang H: Identification of glycoproteins associated with different histological subtypes of ovarian tumors using quantitative glycoproteomics. Proteomics 2011, 11:4677-4687.
56Bandhakavi S, Van Riper SK, Tawfik PN, Stone MD, Haddad T, Rhodus NL, Carlis JV, Griffin TJ: Hexapeptide Libraries for Enhanced Protein PTM Identification and Relative Abundance Profiling in Whole Human Saliva. Journal of Proteome Research 2011, 10:1052-1061.
64Chen R, Jiang X, Sun D, Han G, Wang F, Ye M, Wang L, Zou H: Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry. J Proteome Res 2009, 8:651-661.
75Sun B, Ranish JA, Utleg AG, White JT, Yan X, Lin B, Hood L: Shotgun glycopeptide capture approach coupled with mass Spectrometry for comprehensive glycoproteomics. Molecular & Cellular Proteomics 2007, 6:141-149.