Contains      

UniProtKB-Q92820

Protein Gamma-glutamyl hydrolase
Gene GGH
Status Reviewed
Source Breast cancer xenografts; Breast cell lines; Breast tumor; Colorectal tumors; DLBCL cell lines (Diffuse large B-cell lymphoma); HCC cell lines (Liver); LNCap/PC3 cell lines (Prostate cancer); Liver; Non-small Cell Lung Carcinoma; OVCAR-3 cell line (Ovarian cancer); Ovarian tumor; Platelet; Prostate; Prostate cancer metastasis to liver; Prostate tumor; Serum; Spermatozoa; TPC-1 Cell Line (Thyroid Cance); Urine
Years 2007-2015

Glycosites

Site Identified Peptides Year(Publication ID)
116 IFYnLSI 2014(33);
116 IFYnLSIQ 2014(33);
116 IFYnLSIQS 2014(33);
116 IFYnLSIQSF 2014(33);
116 IFYnLSIQSFD 2014(33);
116 IFYnLSIQSFDDGDYFPV 2007(unpublished);2007 (Unpublished );
163 nFTGGQLHSR 2014(33); 2015(unpublished);2015(1);
163 nFTGGQLHSRMF 2014(33);
163 PLnFTGGQLHSR 2007(33); 2014(unpublished);2007(unpublished);2007;
163 TATDTVDVAMPLnF 2014(33);
163 VDVAMPLnFTGGQLHSR 2014(14); 2014(33); 2015(unpublished);
163 TDTVDVAMPLnFTGGQLHSR 2014(14);
163 TATDTVDVAMPLnFTGGQLHSR 2014(33);
163 TATDTVDVAMPLnFTGGQLHSRMF 2014(33);
163 CLLTATDTVDVAMPLnFTGGQLHSR 2014(33);
203 nFTMNEK 2013(40); 2014(14); 2014(16); 2014(33); 2015(unpublished);2015(1); 2015(2); 2015(unpublished);2015(unpublished);
203 nFTMNEKLK 2014(18);
203 WSISVKnFTMNEK 2013(43);
203 WSLSVKnFTMNEK 2007(62); 2009(68); 2009(52); 2012(18); 2014(2); 2015(unpublished);2015(unpublished);2007(unpublished);2007(unpublished);2007;2007;
307 IYTGnISSF 2014(33);
307 SPIYTGnISSF 2014(33);
307 FSPIYTGnISSF 2014(33);
307 QFSPIYTGnISSF 2014(33);
307 ALIYQFSPIYTGnISSF 2014(33);
307 KALIYQFSPIYTGnISSF 2014(33);
307 ALIYQFSPIYTGnISSFQQ 2015(unpublished);
307 ALIYQFSPIYTGnISSFQQCYIF 2007(unpublished);
307 ALIYQFSPIYTGnISSFQQCYIFD 2015(2); 2015(unpublished);2015(unpublished);
307 SESEEEKAIIYQFSPIYTGnISSFQQCYIFD 2013(43);

Sequence

1112131415161718191
MASPGCLLCVLGLLLCGAASLELSRPHGDTAKKPIIGILMQKCRNKVMKNYGRYYIAASYVKYLESAGARVVPVRLDLTEKDYEILFKSINGILFPGGSV
101111121131141151161171181191
DLRRSDYAKVAKIFYNLSIQSFDDGDYFPVWGTCLGFEELSLLISGECLLTATDTVDVAMPLNFTGGQLHSRMFQNFPTELLLSLAVEPLTANFHKWSLS
201211221231241251261271281291
VKNFTMNEKLKKFFNVLTTNTDGKIEFISTMEGYKYPVYGVQWHPEKAPYEWKNLDGISHAPNAVKTAFYLAEFFVNEARKNNHHFKSESEEEKALIYQF
301311
SPIYTGNISSFQQCYIFD

Reference

ID Publication
1Sun S, Shah P, Eshghi ST, Yang W, Trikannad N, Yang S, Chen L, Aiyetan P, Hoti N, Zhang Z, et al: Comprehensive analysis of protein glycosylation by solid-phase extraction of N-linked glycans and glycosite-containing peptides. Nat Biotech 2015, advance online publication.
2Shah P, Wang X, Yang W, Eshghi ST, Sun S, Hoti N, Chen L, Yang S, Pasay J, Rubin A: Integrated Proteomic and Glycoproteomic Analyses of Prostate Cancer Cells Reveal Glycoprotein Alteration in Protein Abundance and Glycosylation. Molecular & Cellular Proteomics 2015, 14:2753-2763.
14Liu Y, Chen J, Sethi A, Li QK, Chen L, Collins B, Gillet LC, Wollscheid B, Zhang H, Aebersold R: Glycoproteomic analysis of prostate cancer tissues by SWATH mass spectrometry discovers N-acylethanolamine acid amidase and protein tyrosine kinase 7 as signatures for tumor aggressiveness. Molecular & Cellular Proteomics 2014, 13:1753-1768.
16Deeb SJ, Cox J, Schmidt-Supprian M, Mann M: N-linked Glycosylation Enrichment for In-depth Cell Surface Proteomics of Diffuse Large B-cell Lymphoma Subtypes. Molecular & Cellular Proteomics 2014, 13:240-251.
18Hirao Y, Matsuzaki H, Iwaki J, Kuno A, Kaji H, Ohkura T, Togayachi A, Abe M, Nomura M, Noguchi M, et al: Glycoproteomics Approach for Identifying Glycobiomarker Candidate Molecules for Tissue Type Classification of Non-small Cell Lung Carcinoma. Journal of Proteome Research 2014, 13:4705-4716.
33Zhu J, Sun Z, Cheng K, Chen R, Ye M, Xu B, Sun D, Wang L, Liu J, Wang F, Zou H: Comprehensive Mapping of Protein N-Glycosylation in Human Liver by Combining Hydrophilic Interaction Chromatography and Hydrazide Chemistry. Journal of Proteome Research 2014, 13:1713-1721.
40Li X, Jiang J, Zhao X, Wang J, Han H, Zhao Y, Peng B, Zhong R, Ying W, Qian X: N-glycoproteome Analysis of the Secretome of Human Metastatic Hepatocellular Carcinoma Cell Lines Combining Hydrazide Chemistry, HILIC Enrichment and Mass Spectrometry. Plos One 2013, 8.
43Wang GG, Wu YB, Zhou T, Guo YS, Zheng B, Wang J, Bi Y, Liu FJ, Zhou ZM, Guo XJ, Sha JH: Mapping of the N-Linked Glycoproteome of Human Spermatozoa. Journal of Proteome Research 2013, 12:5750-5759.
52Yen T-Y, Macher BA, McDonald CA, Alleyne-Chin C, Timpe LC: Glycoprotein Profiles of Human Breast Cells Demonstrate a Clear Clustering of Normal/Benign versus Malignant Cell Lines and Basal versus Luminal Cell Lines. Journal of Proteome Research 2012, 11:656-667.
62Arcinas A, Yen T-Y, Kebebew E, Macher BA: Cell Surface and Secreted Protein Profiles of Human Thyroid Cancer Cell Lines Reveal Distinct Glycoprotein Patterns. Journal of Proteome Research 2009, 8:3958-3968.
68Zhang L, Xu Y, Yao H, Xie L, Yao J, Lu H, Yang P: Boronic Acid Functionalized Core-Satellite Composite Nanoparticles for Advanced Enrichment of Glycopeptides and Glycoproteins. Chemistry-a European Journal 2009, 15:10158-10166.