Detail

UniProtKB-Q92824


Protein	Proprotein convertase subtilisin/kexin type 5
Gene	PCSK5
Status	Reviewed
Source	Breast Cancer cell lines; Colorectal tumor; HCC cell lines (Liver); HuH-7 cell line (Liver); Non-small Cell Lung Carcinoma; Urine
Years	2007-2014

Glycosites

Site	Identified Peptides	Year(Publication ID)
665	nNTRICVSSCPPGHYHADKK	2007(unpublished);
752	TCTEFHnCTECR	2013(38); 2013(40); 2014(18);
752	TCTEFHnCTECRD	2013(37);
752	TCTEFHnCTECRDGLSLQGSR	2013(38);
1191	TCnGSATLCTSCPK	2014(22);
1561	EGYYADnSTGR	2014(22);

Sequence

1	11	21	31	41	51	61	71	81	91
MGWGSRCCCP	GRLDLLCVLA	LLGGCLLPVC	RTRVYTNHWA	VKIAGGFPEA	NRIASKYGFI	NIGQIGALKD	YYHFYHSRTI	KRSVISSRGT	HSFISMEPKV
101	111	121	131	141	151	161	171	181	191
EWIQQQVVKK	RTKRDYDFSR	AQSTYFNDPK	WPSMWYMHCS	DNTHPCQSDM	NIEGAWKRGY	TGKNIVVTIL	DDGIERTHPD	LMQNYDALAS	CDVNGNDLDP
201	211	221	231	241	251	261	271	281	291
MPRYDASNEN	KHGTRCAGEV	AAAANNSHCT	VGIAFNAKIG	GVRMLDGDVT	DMVEAKSVSF	NPQHVHIYSA	SWGPDDDGKT	VDGPAPLTRQ	AFENGVRMGR
301	311	321	331	341	351	361	371	381	391
RGLGSVFVWA	SGNGGRSKDH	CSCDGYTNSI	YTISISSTAE	SGKKPWYLEE	CSSTLATTYS	SGESYDKKII	TTDLRQRCTD	NHTGTSASAP	MAAGIIALAL
401	411	421	431	441	451	461	471	481	491
EANPFLTWRD	VQHVIVRTSR	AGHLNANDWK	TNAAGFKVSH	LYGFGLMDAE	AMVMEAEKWT	TVPRQHVCVE	STDRQIKTIR	PNSAVRSIYK	ASGCSDNPNR
501	511	521	531	541	551	561	571	581	591
HVNYLEHVVV	RITITHPRRG	DLAIYLTSPS	GTRSQLLANR	LFDHSMEGFK	NWEFMTIHCW	GERAAGDWVL	EVYDTPSQLR	NFKTPGKLKE	WSLVLYGTSV
601	611	621	631	641	651	661	671	681	691
QPYSPTNEFP	KVERFRYSRV	EDPTDDYGTE	DYAGPCDPEC	SEVGCDGPGP	DHCNDCLHYY	YKLKNNTRIC	VSSCPPGHYH	ADKKRCRKCA	PNCESCFGSH
701	711	721	731	741	751	761	771	781	791
GDQCMSCKYG	YFLNEETNSC	VTHCPDGSYQ	DTKKNLCRKC	SENCKTCTEF	HNCTECRDGL	SLQGSRCSVS	CEDGRYFNGQ	DCQPCHRFCA	TCAGAGADGC
801	811	821	831	841	851	861	871	881	891
INCTEGYFME	DGRCVQSCSI	SYYFDHSSEN	GYKSCKKCDI	SCLTCNGPGF	KNCTSCPSGY	LLDLGMCQMG	AICKDGEYVD	EHGHCQTCEA	SCAKCQGPTQ
901	911	921	931	941	951	961	971	981	991
EDCTTCPMTR	IFDDGRCVSN	CPSWKFEFEN	QCHPCHHTCQ	RCQGSGPTHC	TSCGADNYGR	EHFLYQGECG	DSCPEGHYAT	EGNTCLPCPD	NCELCHSVHV
1001	1011	1021	1031	1041	1051	1061	1071	1081	1091
CTRCMKGYFI	APTNHTCQKL	ECGQGEVQDP	DYEECVPCEE	GCLGCSLDDP	GTCTSCAMGY	YRFDHHCYKT	CPEKTYSEEV	ECKACDSNCG	SCDQNGCYWC
1101	1111	1121	1131	1141	1151	1161	1171	1181	1191
EEGFFLLGGS	CVRKCGPGFY	GDQEMGECES	CHRACETCTG	PGHDECSSCQ	EGLQLLRGMC	VHATKTQEEG	KFWNDILRKL	QPCHSSCKTC	NGSATLCTSC
1201	1211	1221	1231	1241	1251	1261	1271	1281	1291
PKGAYLLAQA	CVSSCPQGTW	PSVRSGSCEN	CTEACAICSG	ADLCKKCQMQ	PGHPLFLHEG	RCYSKCPEGS	YAEDGICERC	SSPCRTCEGN	ATNCHSCEGG
1301	1311	1321	1331	1341	1351	1361	1371	1381	1391
HVLHHGVCQE	NCPERHVAVK	GVCKHCPEMC	QDCIHEKTCK	ECTPEFFLHD	DMCHQSCPRG	FYADSRHCVP	CHKDCLECSG	PKADDCELCL	ESSWVLYDGL
1401	1411	1421	1431	1441	1451	1461	1471	1481	1491
CLEECPAGTY	YEKETKECRD	CHKSCLTCSS	SGTCTTCQKG	LIMNPRGSCM	ANEKCSPSEY	WDEDAPGCKP	CHVKCFHCMG	PAEDQCQTCP	MNSLLLNTTC
1501	1511	1521	1531	1541	1551	1561	1571	1581	1591
VKDCPEGYYA	DEDSNRCAHC	HSSCRTCEGR	HSRQCHSCRP	GWFQLGKECL	LQCREGYYAD	NSTGRCERCN	RSCKGCQGPR	PTDCLSCDRF	FFLLRSKGEC
1601	1611	1621	1631	1641	1651	1661	1671	1681	1691
HRSCPDHYYV	EQSTQTCERC	HPTCDQCKGK	GALNCLSCVW	SYHLMGGICT	SDCLVGEYRV	GEGEKFNCEK	CHESCMECKG	PGAKNCTLCP	ANLVLHMDDS
1701	1711	1721	1731	1741	1751	1761	1771	1781	1791
HCLHCCNTSD	PPSAQECCDC	QDTTDECILR	TSKVRPATEH	FKTALFITSS	MMLVLLLGAA	VVVWKKSRGR	VQPAAKAGYE	KLADPNKSYS	SYKSSYREST
1801	1811	1821	1831	1841	1851
SFEEDQVIEY	RDRDYDEDDD	DDIVYMGQDG	TVYRKFKYGL	LDDDDIDELE	YDDESYSYYQ

Reference

ID	Publication
18	Hirao Y, Matsuzaki H, Iwaki J, Kuno A, Kaji H, Ohkura T, Togayachi A, Abe M, Nomura M, Noguchi M, et al: Glycoproteomics Approach for Identifying Glycobiomarker Candidate Molecules for Tissue Type Classification of Non-small Cell Lung Carcinoma. Journal of Proteome Research 2014, 13:4705-4716.
22	Nicastri A, Gaspari M, Sacco R, Elia L, Gabriele C, Romano R, Rizzuto A, Cuda G: N-Glycoprotein Analysis Discovers New Up-Regulated Glycoproteins in Colorectal Cancer Tissue. Journal of Proteome Research 2014, 13:4932-4941.
37	Boersema PJ, Geiger T, Wisniewski JR, Mann M: Quantification of the N-glycosylated Secretome by Super-SILAC During Breast Cancer Progression and in Human Blood Samples. Molecular & Cellular Proteomics 2013, 12:158-171.
38	Kaji H, Ocho M, Togayachi A, Kuno A, Sogabe M, Ohkura T, Nozaki H, Angata T, Chiba Y, Ozaki H, et al: Glycoproteomic Discovery of Serological Biomarker Candidates for HCV/HBV Infection-Associated Liver Fibrosis and Hepatocellular Carcinoma. Journal of Proteome Research 2013, 12:2630-2640.
40	Li X, Jiang J, Zhao X, Wang J, Han H, Zhao Y, Peng B, Zhong R, Ying W, Qian X: N-glycoproteome Analysis of the Secretome of Human Metastatic Hepatocellular Carcinoma Cell Lines Combining Hydrazide Chemistry, HILIC Enrichment and Mass Spectrometry. Plos One 2013, 8.