Detail

UniProtKB-Q92932


Protein	Receptor-type tyrosine-protein phosphatase N2
Gene	PTPRN2
Status	Reviewed
Source	Breast Cancer cell lines; Colorectal tumor; HCC cell lines (Liver); OVCAR-3 cell line (Ovarian cancer); Ovarian tumor; Pancreatic islets; Prostate; Prostate tumor; Urine; ovarian tumor
Years	2007-2015

Glycosites

Site	Identified Peptides	Year(Publication ID)
564	nVTTEDVEK	2015(1);
564	VQnVTTEDVEK	2014(14); 2015(unpublished);
564	NVQnVTTEDVEK	2014(14);
564	ANVQnVTTEDVEK	2014(14); 2015(unpublished);
564	VSANVQnVTTEDV	2013(37);
564	VSANVQnVTTEDVE	2014(14); 2015(unpublished);
564	VSANVQnVTTEDVEK	2011(54); 2012(48); 2014(14); 2014(22); 2015(unpublished);2015(unpublished);2015;2007;2007;
760	nSSFVAQR	2007(unpublished);
898	NLQTnETR	2013(40);

Sequence

1	11	21	31	41	51	61	71	81	91
MGPPLPLLLL	LLLLLPPRVL	PAAPSSVPRG	RQLPGRLGCL	LEEGLCGASE	ACVNDGVFGR	CQKVPAMDFY	RYEVSPVALQ	RLRVALQKLS	GTGFTWQDDY
101	111	121	131	141	151	161	171	181	191
TQYVMDQELA	DLPKTYLRRP	EASSPARPSK	HSVGSERRYS	REGGAALANA	LRRHLPFLEA	LSQAPASDVL	ARTHTAQDRP	PAEGDDRFSE	SILTYVAHTS
201	211	221	231	241	251	261	271	281	291
ALTYPPGSRT	QLREDLLPRT	LGQLQPDELS	PKVDSGVDRH	HLMAALSAYA	AQRPPAPPGE	GSLEPQYLLR	APSRMPRPLL	APAAPQKWPS	PLGDSEDPSS
301	311	321	331	341	351	361	371	381	391
TGDGARIHTL	LKDLQRQPAE	VRGLSGLELD	GMAELMAGLM	QGVDHGVARG	SPGRAALGES	GEQADGPKAT	LRGDSFPDDG	VQDDDDRLYQ	EVHRLSATLG
401	411	421	431	441	451	461	471	481	491
GLLQDHGSRL	LPGALPFARP	LDMERKKSEH	PESSLSSEEE	TAGVENVKSQ	TYSKDLLGQQ	PHSEPGAAAF	GELQNQMPGP	SKEEQSLPAG	AQEALSDGLQ
501	511	521	531	541	551	561	571	581	591
LEVQPSEEEA	RGYIVTDRDP	LRPEEGRRLV	EDVARLLQVP	SSAFADVEVL	GPAVTFKVSA	NVQNVTTEDV	EKATVDNKDK	LEETSGLKIL	QTGVGSKSKL
601	611	621	631	641	651	661	671	681	691
KFLPPQAEQE	DSTKFIALTL	VSLACILGVL	LASGLIYCLR	HSSQHRLKEK	LSGLGGDPGA	DATAAYQELC	RQRMATRPPD	RPEGPHTSRI	SSVSSQFSDG
701	711	721	731	741	751	761	771	781	791
PIPSPSARSS	ASSWSEEPVQ	SNMDISTGHM	ILSYMEDHLK	NKNRLEKEWE	ALCAYQAEPN	SSFVAQREEN	VPKNRSLAVL	TYDHSRVLLK	AENSHSHSDY
801	811	821	831	841	851	861	871	881	891
INASPIMDHD	PRNPAYIATQ	GPLPATVADF	WQMVWESGCV	VIVMLTPLAE	NGVRQCYHYW	PDEGSNLYHI	YEVNLVSEHI	WCEDFLVRSF	YLKNLQTNET
901	911	921	931	941	951	961	971	981	991
RTVTQFHFLS	WYDRGVPSSS	RSLLDFRRKV	NKCYRGRSCP	IIVHCSDGAG	RSGTYVLIDM	VLNKMAKGAK	EIDIAATLEH	LRDQRPGMVQ	TKEQFEFALT
1001	1011
AVAEEVNAIL	KALPQ

Reference

ID	Publication
1	Sun S, Shah P, Eshghi ST, Yang W, Trikannad N, Yang S, Chen L, Aiyetan P, Hoti N, Zhang Z, et al: Comprehensive analysis of protein glycosylation by solid-phase extraction of N-linked glycans and glycosite-containing peptides. Nat Biotech 2015, advance online publication.
14	Liu Y, Chen J, Sethi A, Li QK, Chen L, Collins B, Gillet LC, Wollscheid B, Zhang H, Aebersold R: Glycoproteomic analysis of prostate cancer tissues by SWATH mass spectrometry discovers N-acylethanolamine acid amidase and protein tyrosine kinase 7 as signatures for tumor aggressiveness. Molecular & Cellular Proteomics 2014, 13:1753-1768.
22	Nicastri A, Gaspari M, Sacco R, Elia L, Gabriele C, Romano R, Rizzuto A, Cuda G: N-Glycoprotein Analysis Discovers New Up-Regulated Glycoproteins in Colorectal Cancer Tissue. Journal of Proteome Research 2014, 13:4932-4941.
37	Boersema PJ, Geiger T, Wisniewski JR, Mann M: Quantification of the N-glycosylated Secretome by Super-SILAC During Breast Cancer Progression and in Human Blood Samples. Molecular & Cellular Proteomics 2013, 12:158-171.
40	Li X, Jiang J, Zhao X, Wang J, Han H, Zhao Y, Peng B, Zhong R, Ying W, Qian X: N-glycoproteome Analysis of the Secretome of Human Metastatic Hepatocellular Carcinoma Cell Lines Combining Hydrazide Chemistry, HILIC Enrichment and Mass Spectrometry. Plos One 2013, 8.
48	Danzer C, Eckhardt K, Schmidt A, Fankhauser N, Ribrioux S, Wollscheid B, Mueller L, Schiess R, Zuellig R, Lehmann R, et al: Comprehensive Description of the N-Glycoproteome of Mouse Pancreatic beta-Cells and Human Islets. Journal of Proteome Research 2012, 11:1598-1608.
54	Tian Y, Yao Z, Roden R, Zhang H: Identification of glycoproteins associated with different histological subtypes of ovarian tumors using quantitative glycoproteomics. Proteomics 2011, 11:4677-4687.