Detail

UniProtKB-Q96PQ0


Protein	VPS10 domain-containing receptor SorCS2
Gene	SORCS2
Status	Reviewed
Source	Breast Cancer cell lines; Breast cancer xenografts; Hela cell line (cervical cancer); Liver; OVCAR-3 cell line (Ovarian cancer); Pancreatic islets; SKOV-3 cell line (Ovarian cancer)
Years	2012-2015

Glycosites

Site	Identified Peptides	Year(Publication ID)
328	YVTCAIHnCSEK	2013(34); 2014(33); 2015(12);
328	VTCAIHnCSEKMI	2013(37);
362	KATSAnQTKY	2014(33);
830	AMYVnLTLTGEPIR	2012(48); 2013(34); 2014(33); 2015(1); 2015(unpublished);

Sequence

1	11	21	31	41	51	61	71	81	91
MAHRGPSRAS	KGPGPTARAP	SPGAPPPPRS	PRSRPLLLLL	LLLGACGAAG	RSPEPGRLGP	HAQLTRVPRS	PPAGRAEPGG	GEDRQARGTE	PGAPGPSPGP
101	111	121	131	141	151	161	171	181	191
APGPGEDGAP	AAGYRRWERA	APLAGVASRA	QVSLISTSFV	LKGDATHNQA	MVHWTGENSS	VILILTKYYH	ADMGKVLESS	LWRSSDFGTS	YTKLTLQPGV
201	211	221	231	241	251	261	271	281	291
TTVIDNFYIC	PTNKRKVILV	SSSLSDRDQS	LFLSADEGAT	FQKQPIPFFV	ETLIFHPKEE	DKVLAYTKES	KLYVSSDLGK	KWTLLQERVT	KDHVFWSVSG
301	311	321	331	341	351	361	371	381	391
VDADPDLVHV	EAQDLGGDFR	YVTCAIHNCS	EKMLTAPFAG	PIDHGSLTVQ	DDYIFFKATS	ANQTKYYVSY	RRNEFVLMKL	PKYALPKDLQ	IISTDESQVF
401	411	421	431	441	451	461	471	481	491
VAVQEWYQMD	TYNLYQSDPR	GVRYALVLQD	VRSSRQAEES	VLIDILEVRG	VKGVFLANQK	IDGKVMTLIT	YNKGRDWDYL	RPPSMDMNGK	PTNCKPPDCH
501	511	521	531	541	551	561	571	581	591
LHLHLRWADN	PYVSGTVHTK	DTAPGLIMGA	GNLGSQLVEY	KEEMYITSDC	GHTWRQVFEE	EHHILYLDHG	GVIVAIKDTS	IPLKILKFSV	DEGLTWSTHN
601	611	621	631	641	651	661	671	681	691
FTSTSVFVDG	LLSEPGDETL	VMTVFGHISF	RSDWELVKVD	FRPSFSRQCG	EEDYSSWELS	NLQGDRCIMG	QQRSFRKRKS	TSWCIKGRSF	TSALTSRVCE
701	711	721	731	741	751	761	771	781	791
CRDSDFLCDY	GFERSSSSES	STNKCSANFW	FNPLSPPDDC	ALGQTYTSSL	GYRKVVSNVC	EGGVDMQQSQ	VQLQCPLTPP	RGLQVSIQGE	AVAVRPGEDV
801	811	821	831	841	851	861	871	881	891
LFVVRQEQGD	VLTTKYQVDL	GDGFKAMYVN	LTLTGEPIRH	RYESPGIYRV	SVRAENTAGH	DEAVLFVQVN	SPLQALYLEV	VPVIGLNQEV	NLTAVLLPLN
901	911	921	931	941	951	961	971	981	991
PNLTVFYWWI	GHSLQPLLSL	DNSVTTRFSD	TGDVRVTVQA	ACGNSVLQDS	RVLRVLDQFQ	VMPLQFSKEL	DAYNPNTPEW	REDVGLVVTR	LLSKETSVPQ
1001	1011	1021	1031	1041	1051	1061	1071	1081	1091
ELLVTVVKPG	LPTLADLYVL	LPPPRPTRKR	SLSSDKRLAA	IQQVLNAQKI	SFLLRGGVRV	LVALRDTGTG	AEQLGGGGGY	WAVVVLFVIG	LFAAGAFILY
1101	1111	1121	1131	1141	1151
KFKRKRPGRT	VYAQMHNEKE	QEMTSPVSHS	EDVQGAVQGN	HSGVVLSINS	REMHSYLVS

Reference

ID	Publication
1	Sun S, Shah P, Eshghi ST, Yang W, Trikannad N, Yang S, Chen L, Aiyetan P, Hoti N, Zhang Z, et al: Comprehensive analysis of protein glycosylation by solid-phase extraction of N-linked glycans and glycosite-containing peptides. Nat Biotech 2015, advance online publication.
12	Weng Y, Sui Z, Jiang H, Shan Y, Chen L, Zhang S, Zhang L, Zhang Y: Releasing N-glycan from Peptide N-terminus by N-terminal Succinylation Assisted Enzymatic Deglycosylation. Scientific Reports 2015, 5.
33	Zhu J, Sun Z, Cheng K, Chen R, Ye M, Xu B, Sun D, Wang L, Liu J, Wang F, Zou H: Comprehensive Mapping of Protein N-Glycosylation in Human Liver by Combining Hydrophilic Interaction Chromatography and Hydrazide Chemistry. Journal of Proteome Research 2014, 13:1713-1721.
34	Sun S, Zhang B, Aiyetan P, Zhou J-Y, Shah P, Yang W, Levine DA, Zhang Z, Chan DW, Zhang H: Analysis of N-glycoproteins using Genomic N-glycosite Prediction. Journal of Proteome Research 2013, 12:5609-5615.
37	Boersema PJ, Geiger T, Wisniewski JR, Mann M: Quantification of the N-glycosylated Secretome by Super-SILAC During Breast Cancer Progression and in Human Blood Samples. Molecular & Cellular Proteomics 2013, 12:158-171.
48	Danzer C, Eckhardt K, Schmidt A, Fankhauser N, Ribrioux S, Wollscheid B, Mueller L, Schiess R, Zuellig R, Lehmann R, et al: Comprehensive Description of the N-Glycoproteome of Mouse Pancreatic beta-Cells and Human Islets. Journal of Proteome Research 2012, 11:1598-1608.