Contains      

UniProtKB-Q99102

Protein Mucin-4
Gene MUC4
Status Reviewed
Source Breast cell lines; Colorectal tumor; Ovarian tumor; Prostate; Prostate tumor; Serum; Urine; milk
Years 2007-2015

Glycosites

Site Identified Peptides Year(Publication ID)
235 TTSTPSFSPSVHnVTGTVSQK 2014(22); 2015(unpublished);
260 SLCSVTnTSMMTSEK 2007(unpublished);
260 TSPSGETATSSLCSVTnTSMMTSEK 2015(unpublished);
622 HTSQQITTAPSTnHSTIHSTSTSPQESPAVSQR 2015(unpublished);
1525 VLLDnQTVTFQPDHEDGGGQETFNATGVLLSR 2012(52); 2015(unpublished);2015(unpublished);2015(unpublished);
1544 VLLDNQTVTFQPDHEDGGGQETFnATGVLLSR 2012(52); 2015(unpublished);2015(unpublished);2015(unpublished);
1609 MPnGSTIPPGSPEEMLFHFGMTWQINGTGLLGK 2015(unpublished);
1632 MPNGSTIPPGSPEEMLFHFGMTWQInGTGLLGK 2015(unpublished);
1647 NDQLPSnFTPVFYSQLQK 2015(unpublished);
1647 RNDQLPSnFTPVFYSQLQK 2012(52); 2015(unpublished);
1685 nASIGLHTR 2014(22);
1739 GQTTLIQYTSNAEDAnFTLR 2015(unpublished);2015(unpublished);
1802 TVVCHCNAESQCLYnQTSR 2012(52); 2014(22); 2015(unpublished);2015(unpublished);
1809 VGnSSLEVAGCK 2007(70); 2008(52); 2012(22); 2014(unpublished);2015(unpublished);2015;2015;2015;2007;2007;
2049 DVTALnVSTLK 2007(52); 2012(14); 2014(22); 2014(unpublished);2015(unpublished);2015(unpublished);2015;2015;2015;2007;2007;2007;

Sequence

1112131415161718191
MKGARWRRVPWVSLSCLCLCLLPHVVPGTTEDTLITGSKTAAPVTSTGSTTATLEGQSTAASSRTSNQDISASSQNHQTKSTETTSKAQTDTLTQMMTST
101111121131141151161171181191
LFSSPSVHNVMETVTQETAPPDEMTTSFPSSVTNTLMMTSKTITMTTSTDSTLGNTEETSTAGTESSTPVTSAVSITAGQEGQSRTTSWRTSIQDTSASS
201211221231241251261271281291
QNHWTRSTQTTRESQTSTLTHRTTSTPSFSPSVHNVTGTVSQKTSPSGETATSSLCSVTNTSMMTSEKITVTTSTGSTLGNPGETSSVPVTGSLMPVTSA
301311321331341351361371381391
ALVTVDPEGQSPATFSRTSTQDTTAFSKNHQTQSVETTRVSQINTLNTLTPVTTSTVLSSPSGFNPSGTVSQETFPSGETTISSPSSVSNTFLVTSKVFR
401411421431441451461471481491
MPISRDSTLGNTEETSLSVSGTISAITSKVSTIWWSDTLSTALSPSSLPPKISTAFHTQQSEGAETTGRPHERSSFSPGVSQEIFTLHETTTWPSSFSSK
501511521531541551561571581591
GHTTWSQTELPSTSTGAATRLVTGNPSTRAAGTIPRVPSKVSAIGEPGEPTTYSSHSTTLPKTTGAGAQTQWTQETGTTGEALLSSPSYSVIQMIKTATS
601611621631641651661671681691
PSSSPMLDRHTSQQITTAPSTNHSTIHSTSTSPQESPAVSQRGHTRAPQTTQESQTTRSVSPMTDTKTVTTPGSSFTASGHSPSEIVPQDAPTISAATTF
701711721731741751761771781791
APAPTGNGHTTQAPTTALQAAPSSHDATLGPSGGTSLSKTGALTLANSVVSTPGGPEGQWTSASASTSPDTAAAMTHTHQAESTEASGQTQTSEPASSGS
801811821831841851861871881891
RTTSAGTATPSSSGASGTTPSGSEGISTSGETTRFSSNPSRDSHTTQSTTELLSASASHGAIPVSTGMASSIVPGTFHPTLSEASTAGRPTGQSSPTSPS
901911921931941951961971981991
ASPQETAAISRMAQTQRTGTSRGSDTISLASQATDTFSTVPPTPPSITSSGLTSPQTQTHTLSPSGSGKTFTTALISNATPLPVTSTSSASTGHATPLAV
1001101110211031104110511061107110811091
SSATSASTVSSDSPLKMETSGMTTPSLKTDGGRRTATSPPPTTSQTIISTIPSTAMHTRSTAAPIPILPERGVSLFPYGAGAGDLEFVRRTVDFTSPLFK
1101111111211131114111511161117111811191
PATGFPLGSSLRDSLYFTDNGQIIFPESDYQIFSYPNPLPTGFTGRDPVALVAPFWDDADFSTGRGTTFYQEYETFYGEHSLLVQQAESWIRKMTNNGGY
1201121112211231124112511261127112811291
KARWALKVTWVNAHAYPAQWTLGSNTYQAILSTDGSRSYALFLYQSGGMQWDVAQRSGNPVLMGFSSGDGYFENSPLMSQPVWERYRPDRFLNSNSGLQG
1301131113211331134113511361137113811391
LQFYRLHREERPNYRLECLQWLKSQPRWPSWGWNQVSCPCSWQQGRRDLRFQPVSIGRWGLGSRQLCSFTSWRGGVCCSYGPWGEFREGWHVQRPWQLAQ
1401141114211431144114511461147114811491
ELEPQSWCCRWNDKPYLCALYQQRRPHVGCATYRPPQPAWMFGDPHITTLDGVSYTFNGLGDFLLVGAQDGNSSFLLQGRTAQTGSAQATNFIAFAAQYR
1501151115211531154115511561157115811591
SSSLGPVTVQWLLEPHDAIRVLLDNQTVTFQPDHEDGGGQETFNATGVLLSRNGSEVSASFDGWATVSVIALSNILHASASLPPEYQNRTEGLLGVWNNN
1601161116211631164116511661167116811691
PEDDFRMPNGSTIPPGSPEEMLFHFGMTWQINGTGLLGKRNDQLPSNFTPVFYSQLQKNSSWAEHLISNCDGDSSCIYDTLALRNASIGLHTREVSKNYE
1701171117211731174117511761177117811791
QANATLNQYPPSINGGRVIEAYKGQTTLIQYTSNAEDANFTLRDSCTDLELFENGTLLWTPKSLEPFTLEILARSAKIGLASALQPRTVVCHCNAESQCL
1801181118211831184118511861187118811891
YNQTSRVGNSSLEVAGCKCDGGTFGRYCEGSEDACEEPCFPSVHCVPGKGCEACPPNLTGDGRHCAALGSSFLCQNQSCPVNYCYNQGHCYISQTLGCQP
1901191119211931194119511961197119811991
MCTCPPAFTDSRCFLAGNNFSPTVNLELPLRVIQLLLSEEENASMAEVNASVAYRLGTLDMRAFLRNSQVERIDSAAPASGSPIQHWMVISEFQYRPRGP
2001201120212031204120512061207120812091
VIDFLNNQLLAAVVEAFLYHVPRRSEEPRNDVVFQPISGEDVRDVTALNVSTLKAYFRCDGYKGYDLVYSPQSGFTCVSPCSRGYCDHGGQCQHLPSGPR
2101211121212131214121512161
CSCVSFSIYTAWGEHCEHLSMKLDAFFGIFFGALGGLLLLGVGTFVVLRFWGCSGARFSYFLNSAEALP

Reference

ID Publication
14Liu Y, Chen J, Sethi A, Li QK, Chen L, Collins B, Gillet LC, Wollscheid B, Zhang H, Aebersold R: Glycoproteomic analysis of prostate cancer tissues by SWATH mass spectrometry discovers N-acylethanolamine acid amidase and protein tyrosine kinase 7 as signatures for tumor aggressiveness. Molecular & Cellular Proteomics 2014, 13:1753-1768.
22Nicastri A, Gaspari M, Sacco R, Elia L, Gabriele C, Romano R, Rizzuto A, Cuda G: N-Glycoprotein Analysis Discovers New Up-Regulated Glycoproteins in Colorectal Cancer Tissue. Journal of Proteome Research 2014, 13:4932-4941.
52Yen T-Y, Macher BA, McDonald CA, Alleyne-Chin C, Timpe LC: Glycoprotein Profiles of Human Breast Cells Demonstrate a Clear Clustering of Normal/Benign versus Malignant Cell Lines and Basal versus Luminal Cell Lines. Journal of Proteome Research 2012, 11:656-667.
70Picariello G, Ferranti P, Mamone G, Roepstorff P, Addeo F: Identification of N-linked glycoproteins in human milk by hydrophilic interaction liquid chromatography and mass spectrometry. Proteomics 2008, 8:3833-3847.