Contains      

UniProtKB-Q9BZZ2

Protein Sialoadhesin
Gene SIGLEC1
Status Reviewed
Source Colorectal tumor; Liver; Liver tumor (HCC); Ovarian tumor; Ovarian tumorPBMC Macrophage cells; PBMC Macrophage cells; Prostate; Prostate tumor; Urine
Years 2007-2015

Glycosites

Site Identified Peptides Year(Publication ID)
159 VDFnCSTPYVCLQE 2014(33);
159 VDFnCSTPYVCLQEQVR 2014(33);
265 TCQVnSSYPAVSSIKW 2014(33);
265 LVTLTCQVnSSYPAVSSIK 2014(33);
265 NILPGELVTLTCQVnSSYPAVSSIK 2007(45); 2013(33); 2014(unpublished);2015(unpublished);2015;2015;2015;2007;2007;
339 nQTVTLVCNTPNEAPSDLR 2014(33);
499 CSATNSIGnATSTIDFHANAAR 2014(32);
499 CSATNSLGnATSTLDFHANAAR 2014(33);
697 LCEASNALGnASTSATF 2014(33);
697 ASNALGnASTSATFNGQATVLAIAPSHTLQE 2014(33);
726 AnLTCNVSR 2014(33);
726 AIAPSHTLQEGTEAnLTCNVSR 2014(33);
730 ANLTCnVSR 2014(33);
730 AIAPSHTLQEGTEANLTCnVSR 2014(33);
741 EAAGSPAnFSWFR 2014(22); 2014(32); 2014(32); 2014(33); 2015(unpublished);
886 RCEATNVLGSSnTSL 2014(33);
886 RCEATNVLGSSnTSLF 2014(33);
1104 EGQLVnLTCLVWTTHPAQLTY 2014(33);
1138 SIPLPnVTVR 2014(33); 2015(unpublished);
1138 LDAHSIPLPnVTVR 2014(33); 2015(unpublished);
1138 DAHSIPLPnVTVRDATSY 2014(33);
1251 SPLGQAnTSLE 2014(33);
1251 SPIGQAnTSIEIR 2014(32);
1251 SPLGQAnTSLELR 2014(14); 2014(22); 2014(33); 2015(unpublished);2015(unpublished);2015;2015;2015;2007;2007;
1462 GAALnLSCR 2014(33);
1462 VVAEPGIDVPEGAAInISCR 2014(32); 2014(32);
1462 VVAEPGLDVPEGAALnLSCR 2014(22); 2014(33); 2015(unpublished);2015(unpublished);2015(unpublished);2015(unpublished);
1476 LLGGPGPVGnSTF 2014(33);
1476 LLGGPGPVGnSTFAWFWNDR 2014(33); 2015(unpublished);
1476 LLGGPGPVGnSTFAWFWNDRR 2014(33);

Sequence

1112131415161718191
MGFLPKLLLLASFFPAGQASWGVSSPQDVQGVKGSCLLIPCIFSFPADVEVPDGITAIWYYDYSGQRQVVSHSADPKLVEARFRGRTEFMGNPEHRVCNL
101111121131141151161171181191
LLKDLQPEDSGSYNFRFEISEVNRWSDVKGTLVTVTEEPRVPTIASPVELLEGTEVDFNCSTPYVCLQEQVRLQWQGQDPARSVTFNSQKFEPTGVGHLE
201211221231241251261271281291
TLHMAMSWQDHGRILRCQLSVANHRAQSEIHLQVKYAPKGVKILLSPSGRNILPGELVTLTCQVNSSYPAVSSIKWLKDGVRLQTKTGVLHLPQAAWSDA
301311321331341351361371381391
GVYTCQAENGVGSLVSPPISLHIFMAEVQVSPAGPILENQTVTLVCNTPNEAPSDLRYSWYKNHVLLEDAHSHTLRLHLATRADTGFYFCEVQNVHGSER
401411421431441451461471481491
SGPVSVVVNHPPLTPVLTAFLETQAGLVGILHCSVVSEPLATLVLSHGGHILASTSGDSDHSPRFSGTSGPNSLRLEIRDLEETDSGEYKCSATNSLGNA
501511521531541551561571581591
TSTLDFHANAARLLISPAAEVVEGQAVTLSCRSGLSPTPDARFSWYLNGALLHEGPGSSLLLPAASSTDAGSYHCRARDGHSASGPSSPAVLTVLYPPRQ
601611621631641651661671681691
PTFTTRLDLDAAGAGAGRRGLLLCRVDSDPPARLQLLHKDRVVATSLPSGGGCSTCGGCSPRMKVTKAPNLLRVEIHNPLLEEEGLYLCEASNALGNAST
701711721731741751761771781791
SATFNGQATVLAIAPSHTLQEGTEANLTCNVSREAAGSPANFSWFRNGVLWAQGPLETVTLLPVARTDAALYACRILTEAGAQLSTPVLLSVLYPPDRPK
801811821831841851861871881891
LSALLDMGQGHMALFICTVDSRPLALLALFHGEHLLATSLGPQVPSHGRFQAKAEANSLKLEVRELGLGDSGSYRCEATNVLGSSNTSLFFQVRGAWVQV
901911921931941951961971981991
SPSPELQEGQAVVLSCQVHTGVPEGTSYRWYRDGQPLQESTSATLRFAAITLTQAGAYHCQAQAPGSATTSLAAPISLHVSYAPRHVTLTTLMDTGPGRL
1001101110211031104110511061107110811091
GLLLCRVDSDPPAQLRLLHGDRLVASTLQGVGGPEGSSPRLHVAVAPNTLRLEIHGAMLEDEGVYICEASNTLGQASASADFDAQAVNVQVWPGATVREG
1101111111211131114111511161117111811191
QLVNLTCLVWTTHPAQLTYTWYQDGQQRLDAHSIPLPNVTVRDATSYRCGVGPPGRAPRLSRPITLDVLYAPRNLRLTYLLESHGGQLALVLCTVDSRPP
1201121112211231124112511261127112811291
AQLALSHAGRLLASSTAASVPNTLRLELRGPQPRDEGFYSCSARSPLGQANTSLELRLEGVRVILAPEAAVPEGAPITVTCADPAAHAPTLYTWYHNGRW
1301131113211331134113511361137113811391
LQEGPAASLSFLVATRAHAGAYSCQAQDAQGTRSSRPAALQVLYAPQDAVLSSFRDSRARSMAVIQCTVDSEPPAELALSHDGKVLATSSGVHSLASGTG
1401141114211431144114511461147114811491
HVQVARNALRLQVQDVPAGDDTYVCTAQNLLGSISTIGRLQVEGARVVAEPGLDVPEGAALNLSCRLLGGPGPVGNSTFAWFWNDRRLHAEPVPTLAFTH
1501151115211531154115511561157115811591
VARAQAGMYHCLAELPTGAAASAPVMLRVLYPPKTPTMMVFVEPEGGLRGILDCRVDSEPLASLTLHLGSRLVASSQPQGAPAEPHIHVLASPNALRVDI
1601161116211631164116511661167116811691
EALRPSDQGEYICSASNVLGSASTSTYFGVRALHRLHQFQQLLWVLGLLVGLLLLLLGLGACYTWRRRRVCKQSMGENSVEMAFQKETTQLIDPDAATCE
1701
TSTCAPPLG

Reference

ID Publication
14Liu Y, Chen J, Sethi A, Li QK, Chen L, Collins B, Gillet LC, Wollscheid B, Zhang H, Aebersold R: Glycoproteomic analysis of prostate cancer tissues by SWATH mass spectrometry discovers N-acylethanolamine acid amidase and protein tyrosine kinase 7 as signatures for tumor aggressiveness. Molecular & Cellular Proteomics 2014, 13:1753-1768.
22Nicastri A, Gaspari M, Sacco R, Elia L, Gabriele C, Romano R, Rizzuto A, Cuda G: N-Glycoprotein Analysis Discovers New Up-Regulated Glycoproteins in Colorectal Cancer Tissue. Journal of Proteome Research 2014, 13:4932-4941.
32Zhang Z, Sun Z, Zhu J, Liu J, Huang G, Ye M, Zou H: High-Throughput Determination of the Site-Specific N-Sialoglycan Occupancy Rates by Differential Oxidation of Glycoproteins Followed with Quantitative Glycoproteomics Analysis. Analytical Chemistry 2014, 86:9830-9837.
33Zhu J, Sun Z, Cheng K, Chen R, Ye M, Xu B, Sun D, Wang L, Liu J, Wang F, Zou H: Comprehensive Mapping of Protein N-Glycosylation in Human Liver by Combining Hydrophilic Interaction Chromatography and Hydrazide Chemistry. Journal of Proteome Research 2014, 13:1713-1721.
45Zhou H, Froehlich JW, Briscoe AC, Lee RS: The GlycoFilter: A Simple and Comprehensive Sample Preparation Platform for Proteomics, N-Glycomics and Glycosylation Site Assignment. Molecular & Cellular Proteomics 2013, 12:2981-2991.