Contains      

UniProtKB-Q9H8L6

Protein Multimerin-2
Gene MMRN2
Status Reviewed
Source Breast cancer xenografts; Breast cell lines; Cerebrospinal fluid; Colorectal tumor; Liver; Ovarian tumor; Pancreatic islets; Plasma; Prostate; Prostate tumor; Serum; Urine; ovarian tumor
Years 2005-2015

Glycosites

Site Identified Peptides Year(Publication ID)
205 ALPGnLTAAVME 2014(33);
205 AIPGnITAAVMEANQTGHEFPDR 2014(32);
205 ALPGnLTAAVMEANQTGHEFPDR 2012(52); 2015(unpublished);2015(unpublished);2015(unpublished);
214 AnQTGHEFPDR 2014(33);
214 AIPGNITAAVMEAnQTGHEFPDR 2014(32);
214 ALPGNLTAAVMEAnQTGHEFPDR 2012(52); 2015(unpublished);2015(unpublished);2015(unpublished);
249 SFnQSLH 2014(33);
249 SFnQSLHSLTQAIR 2012(52); 2014(33); 2015(unpublished);2015(unpublished);2015(unpublished);
261 nLSLDVEANR 2015(unpublished);
350 AQEAPGTnGSLVLATPGAGAR 2012(48); 2014(33); 2015(unpublished);
350 PGTnGSLVLATPGAGARPEPDSLQAR 2011(54); 2007(unpublished);2007(unpublished);
350 AQEAPGTnGSLVLATPGAGARPEPDSLQAR 2012(48); 2012(52); 2013(34); 2014(14); 2014(22); 2014(33); 2015(unpublished);2015(unpublished);2015(unpublished);
379 GQLQRnLSEL 2014(33);
379 nLSELHMTTAR 2014(33); 2015(unpublished);
439 LQVnHTALR 2014(33);
439 LQVnHTALRE 2014(33);
439 QVEELQVnHTALR 2012(52); 2014(33); 2015(unpublished);2015;2007;
472 LnLTLQHLQGGHADLIK 2014(33);
472 QLLELnLTLQHLQGGHADLIK 2014(33); 2015(unpublished);
765 AnVSLDLGK 2014(33);
845 FnTTYINIGSSYFPEHGYFR 2005( 81); 2007(52); 2012(45); 2013(33); 2014(8); 2015(10); 2015(unpublished);2015(unpublished);2015(unpublished);2015(unpublished);2015;2007;2007;2007;2007;

Sequence

1112131415161718191
MILSLLFSLGGPLGWGLLGAWAQASSTSLSDLQSSRTPGVWKAEAEDTGKDPVGRNWCPYPMSKLVTLLALCKTEKFLIHSQQPCPQGAPDCQKVKVMYR
101111121131141151161171181191
MAHKPVYQVKQKVLTSLAWRCCPGYTGPNCEHHDSMAIPEPADPGDSHQEPQDGPVSFKPGHLAAVINEVEVQQEQQEHLLGDLQNDVHRVADSLPGLWK
201211221231241251261271281291
ALPGNLTAAVMEANQTGHEFPDRSLEQVLLPHVDTFLQVHFSPIWRSFNQSLHSLTQAIRNLSLDVEANRQAISRVQDSAVARADFQELGAKFEAKVQEN
301311321331341351361371381391
TQRVGQLRQDVEDRLHAQHFTLHRSISELQADVDTKLKRLHKAQEAPGTNGSLVLATPGAGARPEPDSLQARLGQLQRNLSELHMTTARREEELQYTLED
401411421431441451461471481491
MRATLTRHVDEIKELYSESDETFDQISKVERQVEELQVNHTALRELRVILMEKSLIMEENKEEVERQLLELNLTLQHLQGGHADLIKYVKDCNCQKLYLD
501511521531541551561571581591
LDVIREGQRDATRALEETQVSLDERRQLDGSSLQALQNAVDAVSLAVDAHKAEGERARAATSRLRSQVQALDDEVGALKAAAAEARHEVRQLHSAFAALL
601611621631641651661671681691
EDALRHEAVLAALFGEEVLEEMSEQTPGPLPLSYEQIRVALQDAASGLQEQALGWDELAARVTALEQASEPPRPAEHLEPSHDAGREEAATTALAGLARE
701711721731741751761771781791
LQSLSNDVKNVGRCCEAEAGAGAASLNASLHGLHNALFATQRSLEQHQRLFHSLFGNFQGLMEANVSLDLGKLQTMLSRKGKKQQKDLEAPRKRDKKEAE
801811821831841851861871881891
PLVDIRVTGPVPGALGAALWEAGSPVAFYASFSEGTAALQTVKFNTTYINIGSSYFPEHGYFRAPERGVYLFAVSVEFGPGPGTGQLVFGGHHRTPVCTT
901911921931941
GQGSGSTATVFAMAELQKGERVWFELTQGSITKRSLSGTAFGGFLMFKT

Reference

ID Publication
8Ma C, Zhang Q, Qu JY, Zhao XY, Li X, Liu YP, Wang PG: A precise approach in large scale core-fucosylated glycoprotein identification with low- and high-normalized collision energy. Journal of Proteomics 2015, 114:61-70.
10Tan ZJ, Yin HD, Nie S, Lin ZX, Zhu JH, Ruffin MT, Anderson MA, Simone DM, Lubman DM: Large-Scale Identification of Core-Fucosylated Glycopeptide Sites in Pancreatic Cancer Serum Using Mass Spectrometry. Journal of Proteome Research 2015, 14:1968-1978.
14Liu Y, Chen J, Sethi A, Li QK, Chen L, Collins B, Gillet LC, Wollscheid B, Zhang H, Aebersold R: Glycoproteomic analysis of prostate cancer tissues by SWATH mass spectrometry discovers N-acylethanolamine acid amidase and protein tyrosine kinase 7 as signatures for tumor aggressiveness. Molecular & Cellular Proteomics 2014, 13:1753-1768.
22Nicastri A, Gaspari M, Sacco R, Elia L, Gabriele C, Romano R, Rizzuto A, Cuda G: N-Glycoprotein Analysis Discovers New Up-Regulated Glycoproteins in Colorectal Cancer Tissue. Journal of Proteome Research 2014, 13:4932-4941.
32Zhang Z, Sun Z, Zhu J, Liu J, Huang G, Ye M, Zou H: High-Throughput Determination of the Site-Specific N-Sialoglycan Occupancy Rates by Differential Oxidation of Glycoproteins Followed with Quantitative Glycoproteomics Analysis. Analytical Chemistry 2014, 86:9830-9837.
33Zhu J, Sun Z, Cheng K, Chen R, Ye M, Xu B, Sun D, Wang L, Liu J, Wang F, Zou H: Comprehensive Mapping of Protein N-Glycosylation in Human Liver by Combining Hydrophilic Interaction Chromatography and Hydrazide Chemistry. Journal of Proteome Research 2014, 13:1713-1721.
34Sun S, Zhang B, Aiyetan P, Zhou J-Y, Shah P, Yang W, Levine DA, Zhang Z, Chan DW, Zhang H: Analysis of N-glycoproteins using Genomic N-glycosite Prediction. Journal of Proteome Research 2013, 12:5609-5615.
45Zhou H, Froehlich JW, Briscoe AC, Lee RS: The GlycoFilter: A Simple and Comprehensive Sample Preparation Platform for Proteomics, N-Glycomics and Glycosylation Site Assignment. Molecular & Cellular Proteomics 2013, 12:2981-2991.
48Danzer C, Eckhardt K, Schmidt A, Fankhauser N, Ribrioux S, Wollscheid B, Mueller L, Schiess R, Zuellig R, Lehmann R, et al: Comprehensive Description of the N-Glycoproteome of Mouse Pancreatic beta-Cells and Human Islets. Journal of Proteome Research 2012, 11:1598-1608.
52Yen T-Y, Macher BA, McDonald CA, Alleyne-Chin C, Timpe LC: Glycoprotein Profiles of Human Breast Cells Demonstrate a Clear Clustering of Normal/Benign versus Malignant Cell Lines and Basal versus Luminal Cell Lines. Journal of Proteome Research 2012, 11:656-667.
54Tian Y, Yao Z, Roden R, Zhang H: Identification of glycoproteins associated with different histological subtypes of ovarian tumors using quantitative glycoproteomics. Proteomics 2011, 11:4677-4687.