Detail

UniProtKB-Q9HCK4


Protein	Roundabout homolog 2
Gene	ROBO2
Status	Reviewed
Source	Breast Cancer cell lines; OVCAR-3 cell line (Ovarian cancer); Pancreatic islets
Years	2012-2015

Glycosites

Site	Identified Peptides	Year(Publication ID)
123	nASLEVALLR	2015(1);
426	nQTLAVDGTALLK	2015(1);
782	IWCLGnETR	2012(48);
782	KIWCIGnETRFHI	2013(37);

Sequence

1	11	21	31	41	51	61	71	81	91
MSLLMFTQLL	LCGFLYVRVD	GSRLRQEDFP	PRIVEHPSDV	IVSKGEPTTL	NCKAEGRPTP	TIEWYKDGER	VETDKDDPRS	HRMLLPSGSL	FFLRIVHGRR
101	111	121	131	141	151	161	171	181	191
SKPDEGSYVC	VARNYLGEAV	SRNASLEVAL	LRDDFRQNPT	DVVVAAGEPA	ILECQPPRGH	PEPTIYWKKD	KVRIDDKEER	ISIRGGKLMI	SNTRKSDAGM
201	211	221	231	241	251	261	271	281	291
YTCVGTNMVG	ERDSDPAELT	VFERPTFLRR	PINQVVLEEE	AVEFRCQVQG	DPQPTVRWKK	DDADLPRGRY	DIKDDYTLRI	KKTMSTDEGT	YMCIAENRVG
301	311	321	331	341	351	361	371	381	391
KMEASATLTV	RAPPQFVVRP	RDQIVAQGRT	VTFPCETKGN	PQPAVFWQKE	GSQNLLFPNQ	PQQPNSRCSV	SPTGDLTITN	IQRSDAGYYI	CQALTVAGSI
401	411	421	431	441	451	461	471	481	491
LAKAQLEVTD	VLTDRPPPII	LQGPANQTLA	VDGTALLKCK	ATGDPLPVIS	WLKEGFTFPG	RDPRATIQEQ	GTLQIKNLRI	SDTGTYTCVA	TSSSGETSWS
501	511	521	531	541	551	561	571	581	591
AVLDVTESGA	TISKNYDLSD	LPGPPSKPQV	TDVTKNSVTL	SWQPGTPGTL	PASAYIIEAF	SQSVSNSWQT	VANHVKTTLY	TVRGLRPNTI	YLFMVRAINP
601	611	621	631	641	651	661	671	681	691
QGLSDPSPMS	DPVRTQDISP	PAQGVDHRQV	QKELGDVLVR	LHNPVVLTPT	TVQVTWTVDR	QPQFIQGYRV	MYRQTSGLQA	TSSWQNLDAK	VPTERSAVLV
701	711	721	731	741	751	761	771	781	791
NLKKGVTYEI	KVRPYFNEFQ	GMDSESKTVR	TTEEAPSAPP	QSVTVLTVGS	YNSTSISVSW	DPPPPDHQNG	IIQEYKIWCL	GNETRFHINK	TVDAAIRSVI
801	811	821	831	841	851	861	871	881	891
IGGLFPGIQY	RVEVAASTSA	GVGVKSEPQP	IIIGRRNEVV	ITENNNSITE	QITDVVKQPA	FIAGIGGACW	VILMGFSIWL	YWRRKKRKGL	SNYAVTFQRG
901	911	921	931	941	951	961	971	981	991
DGGLMSNGSR	PGLLNAGDPS	YPWLADSWPA	TSLPVNNSNS	GPNEIGNFGR	GDVLPPVPGQ	GDKTATMLSD	GAIYSSIDFT	TKTSYNSSSQ	ITQATPYATT
1001	1011	1021	1031	1041	1051	1061	1071	1081	1091
QILHSNSIHE	LAVDLPDPQW	KSSIQQKTDL	MGFGYSLPDQ	NKGNNGGKGG	KKKKNKNSSK	PQKNNGSTWA	NVPLPPPPVQ	PLPGTELEHY	AVEQQENGYD
1101	1111	1121	1131	1141	1151	1161	1171	1181	1191
SDSWCPPLPV	QTYLHQGLED	ELEEDDDRVP	TPPVRGVASS	PAISFGQQST	ATLTPSPREE	MQPMLQAHLD	ELTRAYQFDI	AKQTWHIQSN	NQPPQPPVPP
1201	1211	1221	1231	1241	1251	1261	1271	1281	1291
LGYVSGALIS	DLETDVADDD	ADDEEEALEI	PRPLRALDQT	PGSSMDNLDS	SVTGKAFTSS	QRPRPTSPFS	TDSNTSAALS	QSQRPRPTKK	HKGGRMDQQP
1301	1311	1321	1331	1341	1351	1361	1371
ALPHRREGMT	DEEALVPYSK	PSFPSPGGHS	SSGTASSKGS	TGPRKTEVLR	AGHQRNASDL	LDIGYMGSNS	QGQFTGEL

Reference

ID	Publication
1	Sun S, Shah P, Eshghi ST, Yang W, Trikannad N, Yang S, Chen L, Aiyetan P, Hoti N, Zhang Z, et al: Comprehensive analysis of protein glycosylation by solid-phase extraction of N-linked glycans and glycosite-containing peptides. Nat Biotech 2015, advance online publication.
37	Boersema PJ, Geiger T, Wisniewski JR, Mann M: Quantification of the N-glycosylated Secretome by Super-SILAC During Breast Cancer Progression and in Human Blood Samples. Molecular & Cellular Proteomics 2013, 12:158-171.
48	Danzer C, Eckhardt K, Schmidt A, Fankhauser N, Ribrioux S, Wollscheid B, Mueller L, Schiess R, Zuellig R, Lehmann R, et al: Comprehensive Description of the N-Glycoproteome of Mouse Pancreatic beta-Cells and Human Islets. Journal of Proteome Research 2012, 11:1598-1608.