Contains      

UniProtKB-Q9NR97

Protein Toll-like receptor 8
Gene TLR8
Status Reviewed
Source Colorectal tumor; DLBCL cell lines (Diffuse large B-cell lymphoma); Liver; Ovarian tumor; PBMC Macrophage cells; Prostate; Prostate tumor; Serum; Urine
Years 2007-2015

Glycosites

Site Identified Peptides Year(Publication ID)
42 KQnDSVIAE 2014(33);
42 KQnDSVIAECSNR 2014(22); 2014(33); 2015(unpublished);
80 LDLSDNFITHITnE 2014(33);
80 YVTELDLSDNFITHITnESFQGLQNLTK 2009(64);
88 YVTELDLSDNFITHITNESFQGLQnLTK 2009(64);
115 GLnITDGAFLNLKNLR 2007(unpublished);
160 LSLIQNNIYnITK 2014(33);
247 GIInITIIDISGNCPR 2014(16);
247 GLInLTLLDLSGNCPR 2014(33);
285 FAFQnITQIR 2014(16); 2014(32);
285 FAFQnLTQLR 2014(33); 2015(unpublished);2015(unpublished);
293 YInISSTSIR 2014(16);
293 YLnLSSTSLR 2014(33); 2015(unpublished);2015(unpublished);
358 GSYPQHInISR 2014(22); 2014(32); 2014(33); 2015(unpublished);
395 EDDFQPLMQLPnLSTINLGINFIK 2014(33);
443 QSYAnSSSFQR 2014(16);
546 LDFDnASALTELSDLEVLDLSYNSHYFR 2014(33);
582 FIQnFTNLK 2014(33);
582 IAGVTHHIEFIQnFTNIK 2014(16);
582 IAGVTHHLEFIQnFTNLK 2014(33);
590 VLnLSHNNIY 2014(33);
590 VLnLSHNNIYTLTDK 2015(unpublished);
590 VInISHNNIYTITDKYNIESK 2014(16);
752 HLDLSSNLLKTInKSALETK 2007(unpublished);2007(unpublished);
1026 NVVLTEnDSR 2014(14);

Sequence

1112131415161718191
MENMFLQSSMLTCIFLLISGSCELCAEENFSRSYPCDEKKQNDSVIAECSNRRLQEVPQTVGKYVTELDLSDNFITHITNESFQGLQNLTKINLNHNPNV
101111121131141151161171181191
QHQNGNPGIQSNGLNITDGAFLNLKNLRELLLEDNQLPQIPSGLPESLTELSLIQNNIYNITKEGISRLINLKNLYLAWNCYFNKVCEKTNIEDGVFETL
201211221231241251261271281291
TNLELLSLSFNSLSHVPPKLPSSLRKLFLSNTQIKYISEEDFKGLINLTLLDLSGNCPRCFNAPFPCVPCDGGASINIDRFAFQNLTQLRYLNLSSTSLR
301311321331341351361371381391
KINAAWFKNMPHLKVLDLEFNYLVGEIASGAFLTMLPRLEILDLSFNYIKGSYPQHINISRNFSKLLSLRALHLRGYVFQELREDDFQPLMQLPNLSTIN
401411421431441451461471481491
LGINFIKQIDFKLFQNFSNLEIIYLSENRISPLVKDTRQSYANSSSFQRHIRKRRSTDFEFDPHSNFYHFTRPLIKPQCAAYGKALDLSLNSIFFIGPNQ
501511521531541551561571581591
FENLPDIACLNLSANSNAQVLSGTEFSAIPHVKYLDLTNNRLDFDNASALTELSDLEVLDLSYNSHYFRIAGVTHHLEFIQNFTNLKVLNLSHNNIYTLT
601611621631641651661671681691
DKYNLESKSLVELVFSGNRLDILWNDDDNRYISIFKGLKNLTRLDLSLNRLKHIPNEAFLNLPASLTELHINDNMLKFFNWTLLQQFPRLELLDLRGNKL
701711721731741751761771781791
LFLTDSLSDFTSSLRTLLLSHNRISHLPSGFLSEVSSLKHLDLSSNLLKTINKSALETKTTTKLSMLELHGNPFECTCDIGDFRRWMDEHLNVKIPRLVD
801811821831841851861871881891
VICASPGDQRGKSIVSLELTTCVSDVTAVILFFFTFFITTMVMLAALAHHLFYWDVWFIYNVCLAKVKGYRSLSTSQTFYDAYISYDTKDASVTDWVINE
901911921931941951961971981991
LRYHLEESRDKNVLLCLEERDWDPGLAIIDNLMQSINQSKKTVFVLTKKYAKSWNFKTAFYLALQRLMDENMDVIIFILLEPVLQHSQYLRLRQRICKSS
10011011102110311041
ILQWPDNPKAEGLFWQTLRNVVLTENDSRYNNMYVDSIKQY

Reference

ID Publication
14Liu Y, Chen J, Sethi A, Li QK, Chen L, Collins B, Gillet LC, Wollscheid B, Zhang H, Aebersold R: Glycoproteomic analysis of prostate cancer tissues by SWATH mass spectrometry discovers N-acylethanolamine acid amidase and protein tyrosine kinase 7 as signatures for tumor aggressiveness. Molecular & Cellular Proteomics 2014, 13:1753-1768.
16Deeb SJ, Cox J, Schmidt-Supprian M, Mann M: N-linked Glycosylation Enrichment for In-depth Cell Surface Proteomics of Diffuse Large B-cell Lymphoma Subtypes. Molecular & Cellular Proteomics 2014, 13:240-251.
22Nicastri A, Gaspari M, Sacco R, Elia L, Gabriele C, Romano R, Rizzuto A, Cuda G: N-Glycoprotein Analysis Discovers New Up-Regulated Glycoproteins in Colorectal Cancer Tissue. Journal of Proteome Research 2014, 13:4932-4941.
32Zhang Z, Sun Z, Zhu J, Liu J, Huang G, Ye M, Zou H: High-Throughput Determination of the Site-Specific N-Sialoglycan Occupancy Rates by Differential Oxidation of Glycoproteins Followed with Quantitative Glycoproteomics Analysis. Analytical Chemistry 2014, 86:9830-9837.
33Zhu J, Sun Z, Cheng K, Chen R, Ye M, Xu B, Sun D, Wang L, Liu J, Wang F, Zou H: Comprehensive Mapping of Protein N-Glycosylation in Human Liver by Combining Hydrophilic Interaction Chromatography and Hydrazide Chemistry. Journal of Proteome Research 2014, 13:1713-1721.
64Chen R, Jiang X, Sun D, Han G, Wang F, Ye M, Wang L, Zou H: Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry. J Proteome Res 2009, 8:651-661.