Detail

UniProtKB-Q9NYU1


Protein	UDP-glucose:glycoprotein glucosyltransferase 2
Gene	UGGT2
Status	Reviewed
Source	Breast cancer xenografts; LNCap/PC3 cell lines (Prostate cancer); OVCAR-3 cell line (Ovarian cancer); Ovarian tumor; Prostate tumor
Years	2007-2015

Glycosites

Site	Identified Peptides	Year(Publication ID)
256	TVTnTTVEDETETNEVQGFLFGK	2015(unpublished);2015(1); 2015(2); 2015(unpublished);
286	nLTAFQK	2015(1);
286	DnLTAFQK	2015(unpublished);2015(1); 2015(unpublished);
286	LKEIYSDLRDnLTAFQK	2015(2);
920	nMSDFIMK	2015(1);
920	GIVENMGINANnMSDFIMK	2015(1); 2015(2); 2007(unpublished);2007(unpublished);

Sequence

1	11	21	31	41	51	61	71	81	91
MAPAKATNVV	RLLLGSTALW	LSQLGSGTVA	ASKSVTAHLA	AKWPETPLLL	EASEFMAEES	NEKFWQFLET	VQELAIYKQT	ESDYSYYNLI	LKKAGQFLDN
101	111	121	131	141	151	161	171	181	191
LHINLLKFAF	SIRAYSPAIQ	MFQQIAADEP	PPDGCNAFVV	IHKKHTCKIN	EIKKLLKKAA	SRTRPYLFKG	DHKFPTNKEN	LPVVILYAEM	GTRTFSAFHK
201	211	221	231	241	251	261	271	281	291
VLSEKAQNEE	ILYVLRHYIQ	KPSSRKMYLS	GYGVELAIKS	TEYKALDDTQ	VKTVTNTTVE	DETETNEVQG	FLFGKLKEIY	SDLRDNLTAF	QKYLIESNKQ
301	311	321	331	341	351	361	371	381	391
MMPLKVWELQ	DLSFQAASQI	MSAPVYDSIK	LMKDISQNFP	IKARSLTRIA	VNQHMREEIK	ENQKDLQVRF	KIQPGDARLF	INGLRVDMDV	YDAFSILDML
401	411	421	431	441	451	461	471	481	491
KLEGKMMNGL	RNLGINGEDM	SKFLKLNSHI	WEYTYVLDIR	HSSIMWINDL	ENDDLYITWP	TSCQKLLKPV	FPGSVPSIRR	NFHNLVLFID	PAQEYTLDFI
501	511	521	531	541	551	561	571	581	591
KLADVFYSHE	VPLRIGFVFI	LNTDDEVDGA	NDAGVALWRA	FNYIAEEFDI	SEAFISIVHM	YQKVKKDQNI	LTVDNVKSVL	QNTFPHANIW	DILGIHSKYD
601	611	621	631	641	651	661	671	681	691
EERKAGASFY	KMTGLGPLPQ	ALYNGEPFKH	EEMNIKELKM	AVLQRMMDAS	VYLQREVFLG	TLNDRTNAID	FLMDRNNVVP	RINTLILRTN	QQYLNLISTS
701	711	721	731	741	751	761	771	781	791
VTADVEDFST	FFFLDSQDKS	AVIAKNMYYL	TQDDESIISA	VTLWIIADFD	KPSGRKLLFN	ALKHMKTSVH	SRLGIIYNPT	SKINEENTAI	SRGILAAFLT
801	811	821	831	841	851	861	871	881	891
QKNMFLRSFL	GQLAKEEIAT	AIYSGDKIKT	FLIEGMDKNA	FEKKYNTVGV	NIFRTHQLFC	QDVLKLRPGE	MGIVSNGRFL	GPLDEDFYAE	DFYLLEKITF
901	911	921	931	941	951	961	971	981	991
SNLGEKIKGI	VENMGINANN	MSDFIMKVDA	LMSSVPKRAS	RYDVTFLREN	HSVIKTNPQE	NDMFFNVIAI	VDPLTREAQK	MAQLLVVLGK	IINMKIKLFM
1001	1011	1021	1031	1041	1051	1061	1071	1081	1091
NCRGRLSEAP	LESFYRFVLE	PELMSGANDV	SSLGPVAKFL	DIPESPLLIL	NMITPEGWLV	ETVHSNCDLD	NIHLKDTEKT	VTAEYELEYL	LLEGQCFDKV
1101	1111	1121	1131	1141	1151	1161	1171	1181	1191
TEQPPRGLQF	TLGTKNKPAV	VDTIVMAHHG	YFQLKANPGA	WILRLHQGKS	EDIYQIVGHE	GTDSQADLED	IIVVLNSFKS	KILKVKVKKE	TDKIKEDILT
1201	1211	1221	1231	1241	1251	1261	1271	1281	1291
DEDEKTKGLW	DSIKSFTVSL	HKENKKEKDV	LNIFSVASGH	LYERFLRIMM	LSVLRNTKTP	VKFWLLKNYL	SPTFKEVIPH	MAKEYGFRYE	LVQYRWPRWL
1301	1311	1321	1331	1341	1351	1361	1371	1381	1391
RQQTERQRII	WGYKILFLDV	LFPLAVDKII	FVDADQIVRH	DLKELRDFDL	DGAPYGYTPF	CDSRREMDGY	RFWKTGYWAS	HLLRRKYHIS	ALYVVDLKKF
1401	1411	1421	1431	1441	1451	1461	1471	1481	1491
RRIGAGDRLR	SQYQALSQDP	NSLSNLDQDL	PNNMIYQVAI	KSLPQDWLWC	ETWCDDESKQ	RAKTIDLCNN	PKTKESKLKA	AARIVPEWVE	YDAEIRQLLD
1501	1511
HLENKKQDTI	LTHDEL

Reference

ID	Publication
1	Sun S, Shah P, Eshghi ST, Yang W, Trikannad N, Yang S, Chen L, Aiyetan P, Hoti N, Zhang Z, et al: Comprehensive analysis of protein glycosylation by solid-phase extraction of N-linked glycans and glycosite-containing peptides. Nat Biotech 2015, advance online publication.
2	Shah P, Wang X, Yang W, Eshghi ST, Sun S, Hoti N, Chen L, Yang S, Pasay J, Rubin A: Integrated Proteomic and Glycoproteomic Analyses of Prostate Cancer Cells Reveal Glycoprotein Alteration in Protein Abundance and Glycosylation. Molecular & Cellular Proteomics 2015, 14:2753-2763.