| Protein | Endoplasmic reticulum aminopeptidase 1 |
| Gene | ERAP1 |
| Status | Reviewed |
| Source | Breast cancer cell lines; Breast cancer xenografts; Breast tumor; DLBCL cell lines (Diffuse large B-cell lymphoma); HCC cell lines (Liver)Jurkat T cell line; Hela cell line (cervical cancer); K562A cell line (Leukemia); LNCap/PC3 cell lines (Prostate cancer); Liver; Liver tumor (HCC); OVCAR-3 cell line (Ovarian cancer); Ovarian tumor; Pancreatic islets; Prostate; Prostate tumor |
| Years | 2007-2015 |
| Site | Identified Peptides | Year(Publication ID) |
|---|---|---|
| 70 | DLLIHAnL | 2014(33); |
| 70 | IHAnLTTL | 2014(33); |
| 70 | LLIHAnLTTL | 2014(33); |
| 70 | DLLIHAnLTTL | 2014(33); |
| 70 | nLTTLTFWGTTK | 2015(1); |
| 70 | LPEYVIPVHYDLLIHAnLTTLTFWGTTK | 2014(33); |
| 154 | AGnLSETF | 2014(33); |
| 154 | AGnLSETFHGF | 2014(33); |
| 154 | nLSETFHGFYK | 2015(1); |
| 154 | AGnLSETFHGFY | 2014(33); |
| 154 | TVVIHYAGnLSE | 2014(33); |
| 154 | AGnLSETFHGFYK | 2014(33); |
| 154 | TVVIHYAGnLSETF | 2014(33); |
| 154 | YAGnLSETFHGFYK | 2015(unpublished); |
| 154 | TVVIHYAGnLSETFHGFYK | 2015(unpublished); |
| 154 | LVGLPYTVVIHYAGnLSETFHGFYK | 2015(unpublished); |
| 154 | QEQIALLAPEPLLVGLPYTVVIHYAGnLSETFHGFYK | 2014(33); 2015(2); |
| 414 | VDALnSSHP | 2009(64); |
| 414 | VDALnSSHPVS | 2014(33); |
| 414 | DAMEVDALnSSHPVS | 2014(33); |
| 414 | VDALnSSHPVSTPVE | 2014(33); |
| 414 | nSSHPVSTPVENPAQIR | 2014(33); 2015(unpublished);2015(1); |
| 414 | ALnSSHPVSTPVENPAQIR | 2012(48); 2014(33); |
| 414 | DALnSSHPVSTPVENPAQIR | 2012(48); |
| 414 | VDALnSSHPVSTPVENPAQIR | 2014(33); |
| 414 | EVDALnSSHPVSTPVENPAQIR | 2012(48); 2015(unpublished); |
| 414 | VDALnSSHPVSTPVENPAQIRE | 2014(33); |
| 414 | AMEVDALnSSHPVSTPVENPAQIR | 2012(48); |
| 414 | CFDAMEVDAInSSHPVSTPVENPAQIR | 2014(16); 2014(32); 2014(32); |
| 414 | CFDAMEVDALnSSHPVSTPVENPAQIR | 2009(64); 2012(48); 2013(40); 2014(13); 2014(14); 2014(25); 2014(33); 2015(1); 2015(12); 2015(unpublished);2015(unpublished);2015(unpublished);2007(unpublished);2007;2007;2007; |
| 414 | DAMEVDALnSSHPVSTPVENPAQIREMF | 2014(33); |
| 760 | ESNGnLSLPVDVTL | 2014(33); |
| 760 | KESNGnLSLPVDVTL | 2014(33); |
| 760 | KESNGnLSLPVDVTLAVF | 2014(33); |
| 1 | 11 | 21 | 31 | 41 | 51 | 61 | 71 | 81 | 91 |
| MVFLPLKWSL | ATMSFLLSSL | LALLTVSTPS | WCQSTEASPK | RSDGTPFPWN | KIRLPEYVIP | VHYDLLIHAN | LTTLTFWGTT | KVEITASQPT | STIILHSHHL |
| 101 | 111 | 121 | 131 | 141 | 151 | 161 | 171 | 181 | 191 |
| QISRATLRKG | AGERLSEEPL | QVLEHPRQEQ | IALLAPEPLL | VGLPYTVVIH | YAGNLSETFH | GFYKSTYRTK | EGELRILAST | QFEPTAARMA | FPCFDEPAFK |
| 201 | 211 | 221 | 231 | 241 | 251 | 261 | 271 | 281 | 291 |
| ASFSIKIRRE | PRHLAISNMP | LVKSVTVAEG | LIEDHFDVTV | KMSTYLVAFI | ISDFESVSKI | TKSGVKVSVY | AVPDKINQAD | YALDAAVTLL | EFYEDYFSIP |
| 301 | 311 | 321 | 331 | 341 | 351 | 361 | 371 | 381 | 391 |
| YPLPKQDLAA | IPDFQSGAME | NWGLTTYRES | ALLFDAEKSS | ASSKLGITMT | VAHELAHQWF | GNLVTMEWWN | DLWLNEGFAK | FMEFVSVSVT | HPELKVGDYF |
| 401 | 411 | 421 | 431 | 441 | 451 | 461 | 471 | 481 | 491 |
| FGKCFDAMEV | DALNSSHPVS | TPVENPAQIR | EMFDDVSYDK | GACILNMLRE | YLSADAFKSG | IVQYLQKHSY | KNTKNEDLWD | SMASICPTDG | VKGMDGFCSR |
| 501 | 511 | 521 | 531 | 541 | 551 | 561 | 571 | 581 | 591 |
| SQHSSSSSHW | HQEGVDVKTM | MNTWTLQKGF | PLITITVRGR | NVHMKQEHYM | KGSDGAPDTG | YLWHVPLTFI | TSKSDMVHRF | LLKTKTDVLI | LPEEVEWIKF |
| 601 | 611 | 621 | 631 | 641 | 651 | 661 | 671 | 681 | 691 |
| NVGMNGYYIV | HYEDDGWDSL | TGLLKGTHTA | VSSNDRASLI | NNAFQLVSIG | KLSIEKALDL | SLYLKHETEI | MPVFQGLNEL | IPMYKLMEKR | DMNEVETQFK |
| 701 | 711 | 721 | 731 | 741 | 751 | 761 | 771 | 781 | 791 |
| AFLIRLLRDL | IDKQTWTDEG | SVSERMLRSQ | LLLLACVHNY | QPCVQRAEGY | FRKWKESNGN | LSLPVDVTLA | VFAVGAQSTE | GWDFLYSKYQ | FSLSSTEKSQ |
| 801 | 811 | 821 | 831 | 841 | 851 | 861 | 871 | 881 | 891 |
| IEFALCRTQN | KEKLQWLLDE | SFKGDKIKTQ | EFPQILTLIG | RNPVGYPLAW | QFLRKNWNKL | VQKFELGSSS | IAHMVMGTTN | QFSTRTRLEE | VKGFFSSLKE |
| 901 | 911 | 921 | 931 | 941 | |||||
| NGSQLRCVQQ | TIETIEENIG | WMDKNFDKIR | VWLQSEKLER | M |
| ID | Publication |
|---|---|
| 1 | Sun S, Shah P, Eshghi ST, Yang W, Trikannad N, Yang S, Chen L, Aiyetan P, Hoti N, Zhang Z, et al: Comprehensive analysis of protein glycosylation by solid-phase extraction of N-linked glycans and glycosite-containing peptides. Nat Biotech 2015, advance online publication. |
| 2 | Shah P, Wang X, Yang W, Eshghi ST, Sun S, Hoti N, Chen L, Yang S, Pasay J, Rubin A: Integrated Proteomic and Glycoproteomic Analyses of Prostate Cancer Cells Reveal Glycoprotein Alteration in Protein Abundance and Glycosylation. Molecular & Cellular Proteomics 2015, 14:2753-2763. |
| 12 | Weng Y, Sui Z, Jiang H, Shan Y, Chen L, Zhang S, Zhang L, Zhang Y: Releasing N-glycan from Peptide N-terminus by N-terminal Succinylation Assisted Enzymatic Deglycosylation. Scientific Reports 2015, 5. |
| 13 | Yang W, Laeyendecker O, Wendel SK, Zhang B, Sun S, Zhou J-Y, Ao M, Moore RD, Jackson JB, Zhang H: Glycoproteomic Study Reveals Altered Plasma Proteins Associated with HIV Elite Suppressors. Theranostics 2014, 4:1153. |
| 14 | Liu Y, Chen J, Sethi A, Li QK, Chen L, Collins B, Gillet LC, Wollscheid B, Zhang H, Aebersold R: Glycoproteomic analysis of prostate cancer tissues by SWATH mass spectrometry discovers N-acylethanolamine acid amidase and protein tyrosine kinase 7 as signatures for tumor aggressiveness. Molecular & Cellular Proteomics 2014, 13:1753-1768. |
| 16 | Deeb SJ, Cox J, Schmidt-Supprian M, Mann M: N-linked Glycosylation Enrichment for In-depth Cell Surface Proteomics of Diffuse Large B-cell Lymphoma Subtypes. Molecular & Cellular Proteomics 2014, 13:240-251. |
| 25 | Sun Z, Dong J, Zhang S, Hu Z, Cheng K, Li K, Xu B, Ye M, Nie Y, Fan D, Zou H: Identification of Chemoresistance-Related Cell-Surface Glycoproteins in Leukemia Cells and Functional Validation of Candidate Glycoproteins. Journal of Proteome Research 2014, 13:1593-1601. |
| 32 | Zhang Z, Sun Z, Zhu J, Liu J, Huang G, Ye M, Zou H: High-Throughput Determination of the Site-Specific N-Sialoglycan Occupancy Rates by Differential Oxidation of Glycoproteins Followed with Quantitative Glycoproteomics Analysis. Analytical Chemistry 2014, 86:9830-9837. |
| 33 | Zhu J, Sun Z, Cheng K, Chen R, Ye M, Xu B, Sun D, Wang L, Liu J, Wang F, Zou H: Comprehensive Mapping of Protein N-Glycosylation in Human Liver by Combining Hydrophilic Interaction Chromatography and Hydrazide Chemistry. Journal of Proteome Research 2014, 13:1713-1721. |
| 40 | Li X, Jiang J, Zhao X, Wang J, Han H, Zhao Y, Peng B, Zhong R, Ying W, Qian X: N-glycoproteome Analysis of the Secretome of Human Metastatic Hepatocellular Carcinoma Cell Lines Combining Hydrazide Chemistry, HILIC Enrichment and Mass Spectrometry. Plos One 2013, 8. |
| 48 | Danzer C, Eckhardt K, Schmidt A, Fankhauser N, Ribrioux S, Wollscheid B, Mueller L, Schiess R, Zuellig R, Lehmann R, et al: Comprehensive Description of the N-Glycoproteome of Mouse Pancreatic beta-Cells and Human Islets. Journal of Proteome Research 2012, 11:1598-1608. |
| 64 | Chen R, Jiang X, Sun D, Han G, Wang F, Ye M, Wang L, Zou H: Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry. J Proteome Res 2009, 8:651-661. |