Contains      

UniProtKB-Q9UBR2

Protein Cathepsin Z
Gene CTSZ
Status Reviewed
Source Breast cancer xenografts; Breast cell lines; Breast tumor; DLBCL cell lines (Diffuse large B-cell lymphoma); HCC cell lines (Liver); Hela cell line (cervical cancer); HuH-7 cell line (Liver); LNCap/PC3 cell lines (Prostate cancer); Liver; Ovarian tumor; Prostate tumor; Serum; Urine
Years 2007-2015

Glycosites

Site Identified Peptides Year(Publication ID)
184 nYTLWR 2007(52); 2012(40); 2013(45); 2013(33); 2014(2); 2015(12); 2015(unpublished);2015(unpublished);2015;2007;2007;
184 ECHAIRnY 2014(33);
184 KECHAIRnY 2014(33);
184 ECHAIRnYTLW 2014(33);
184 EFKECHAIRnY 2014(33);
184 ECHAIRnYTIWR 2014(16);
184 ECHAIRnYTLWR 2013(38); 2014(33);
184 FKECHAIRnYTL 2009(64);
184 QCGTCNEFKECHAIRnY 2014(33);
184 NQCGTCNEFKECHAIRnY 2014(33);
184 FNQCGTCNEFKECHAIRnY 2014(33);
184 DQECDKFNQCGTCNEFKECHAIRnY 2014(33);
184 QAKDQECDKFNQCGTCNEFKECHAIRnY 2014(33);
184 ETCNNYQAKDQECDKFNQCGTCNEFKECHAIRnY 2014(33);
184 DYAHQHGIPDETCNNYQAKDQECDKFNQCGTCNEFKECHAIRnY 2014(33);
224 ERLAnY 2014(33);
224 ATERLAnY 2014(33);
224 LAnYTGGIY 2014(33);
224 MATERLAnY 2014(33);
224 IMATERLAnY 2014(33);
224 GIMATERLAnY 2014(33);
224 LAnYTGGIYAE 2014(33);
224 LAnYTGGIYAEY 2014(33);
224 RLAnYTGGIYAE 2013(42); 2014(33);
224 ATERLAnYTGGIY 2014(33);
224 LAnYTGGIYAEYQ 2007(unpublished);2007(unpublished);2007(unpublished);
224 ATERLAnYTGGIYAEY 2014(33);
224 LAnYTGGIYAEYQDTTY 2014(19); 2014(33);
224 ANGPISCGIMATERLAnY 2014(33);
224 ATERLAnYTGGIYAEYQDTTY 2014(33);
224 LAnYTGGIYAEYQDTTYINHVVSVAGWGISDGTEYWIVR 2015(2);

Sequence

1112131415161718191
MARRGPGWRPLLLLVLLAGAAQGGLYFRRGQTCYRPLRGDGLAPLGRSTYPRPHEYLSPADLPKSWDWRNVDGVNYASITRNQHIPQYCGSCWAHASTSA
101111121131141151161171181191
MADRINIKRKGAWPSTLLSVQNVIDCGNAGSCEGGNDLSVWDYAHQHGIPDETCNNYQAKDQECDKFNQCGTCNEFKECHAIRNYTLWRVGDYGSLSGRE
201211221231241251261271281291
KMMAEIYANGPISCGIMATERLANYTGGIYAEYQDTTYINHVVSVAGWGISDGTEYWIVRNSWGEPWGERGWLRIVTSTYKDGKGARYNLAIEEHCTFGD
301
PIV

Reference

ID Publication
2Shah P, Wang X, Yang W, Eshghi ST, Sun S, Hoti N, Chen L, Yang S, Pasay J, Rubin A: Integrated Proteomic and Glycoproteomic Analyses of Prostate Cancer Cells Reveal Glycoprotein Alteration in Protein Abundance and Glycosylation. Molecular & Cellular Proteomics 2015, 14:2753-2763.
12Weng Y, Sui Z, Jiang H, Shan Y, Chen L, Zhang S, Zhang L, Zhang Y: Releasing N-glycan from Peptide N-terminus by N-terminal Succinylation Assisted Enzymatic Deglycosylation. Scientific Reports 2015, 5.
16Deeb SJ, Cox J, Schmidt-Supprian M, Mann M: N-linked Glycosylation Enrichment for In-depth Cell Surface Proteomics of Diffuse Large B-cell Lymphoma Subtypes. Molecular & Cellular Proteomics 2014, 13:240-251.
19Huang G, Sun Z, Qin H, Zhao L, Xiong Z, Peng X, Ou J, Zou H: Preparation of hydrazine functionalized polymer brushes hybrid magnetic nanoparticles for highly specific enrichment of glycopeptides. Analyst 2014, 139:2199-2206.
33Zhu J, Sun Z, Cheng K, Chen R, Ye M, Xu B, Sun D, Wang L, Liu J, Wang F, Zou H: Comprehensive Mapping of Protein N-Glycosylation in Human Liver by Combining Hydrophilic Interaction Chromatography and Hydrazide Chemistry. Journal of Proteome Research 2014, 13:1713-1721.
38Kaji H, Ocho M, Togayachi A, Kuno A, Sogabe M, Ohkura T, Nozaki H, Angata T, Chiba Y, Ozaki H, et al: Glycoproteomic Discovery of Serological Biomarker Candidates for HCV/HBV Infection-Associated Liver Fibrosis and Hepatocellular Carcinoma. Journal of Proteome Research 2013, 12:2630-2640.
40Li X, Jiang J, Zhao X, Wang J, Han H, Zhao Y, Peng B, Zhong R, Ying W, Qian X: N-glycoproteome Analysis of the Secretome of Human Metastatic Hepatocellular Carcinoma Cell Lines Combining Hydrazide Chemistry, HILIC Enrichment and Mass Spectrometry. Plos One 2013, 8.
42Ma C, Zhao X, Han H, Tong W, Zhang Q, Qin P, Chang C, Peng B, Ying W, Qian X: N-linked glycoproteome profiling of human serum using tandem enrichment and multiple fraction concatenation. Electrophoresis 2013, 34:2440-2450.
45Zhou H, Froehlich JW, Briscoe AC, Lee RS: The GlycoFilter: A Simple and Comprehensive Sample Preparation Platform for Proteomics, N-Glycomics and Glycosylation Site Assignment. Molecular & Cellular Proteomics 2013, 12:2981-2991.
52Yen T-Y, Macher BA, McDonald CA, Alleyne-Chin C, Timpe LC: Glycoprotein Profiles of Human Breast Cells Demonstrate a Clear Clustering of Normal/Benign versus Malignant Cell Lines and Basal versus Luminal Cell Lines. Journal of Proteome Research 2012, 11:656-667.
64Chen R, Jiang X, Sun D, Han G, Wang F, Ye M, Wang L, Zou H: Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry. J Proteome Res 2009, 8:651-661.