Protein | Transmembrane protein 2 |
Gene | TMEM2 |
Status | Reviewed |
Source | Breast Cancer cell lines; Breast cancer xenografts; Breast cell lines; Colorectal cancer cell line, HCT-116 (colorectal cancer); Colorectal tumor; DLBCL cell lines (Diffuse large B-cell lymphoma); HCC cell lines (Liver); HEK293 cell line (embryonic kidney); Hela cell line (cervical cancer); HuH-7 cell line (Liver); IGROV-1/CP cell line (Ovarian cancer)IGROV-1/CP; Jurkat T cell line; LNCap/PC3 cell lines (Prostate cancer); Liver; Liver tumor (HCC); Non-small Cell Lung Carcinoma; OVCAR-3 cell line (Ovarian cancer); Ovarian tumor; Pancreatic islets; Prostate; Prostate cancer metastasis to liver; Prostate tumor; SKOV-3 cell line (Ovarian cancer) |
Years | 2007-2015 |
Site | Identified Peptides | Year(Publication ID) |
---|---|---|
171 | nITIR | 2014(33); |
171 | nITLR | 2014(33); |
171 | nLTIR | 2014(33); |
171 | nLTLR | 2014(33); |
248 | TLnSSGLPFGSY | 2014(33); |
248 | TLLARTLnSSGLPF | 2014(33); |
248 | TLnSSGLPFGSYTFE | 2014(33); |
248 | TInSSGIPFGSYTFEK | 2014(32); |
248 | TLnSSGLPFGSYTFEK | 2011(58); 2012(52); 2013(34); 2013(40); 2014(13); 2014(14); 2014(15); 2014(33); 2015(unpublished);2015(1); 2015(unpublished); |
248 | TInSSGIPFGSYTFEKDFSR | 2014(16); |
248 | TLnSSGLPFGSYTFEKDFSR | 2011(58); 2014(15); 2014(18); 2014(33); 2015(12); |
292 | FDTHEYRnE | 2014(33); |
292 | FDTHEYRnESR | 2012(48); 2013(40); 2014(33); 2015(unpublished);2015(1); 2015(2); 2015(unpublished); |
292 | IIESERFDTHEYRnESR | 2014(16); |
292 | ILESERFDTHEYRnESR | 2014(33); 2015(1); |
362 | ALVGVIDGGSTSCnESVR | 2014(33); |
362 | ALVGVIDGGSTSCnESVRNY | 2014(33); |
362 | QAWALVGVIDGGSTSCnESVR | 2007(unpublished);2014(33); 2015(1); |
525 | IMKnFTSVHL | 2014(33); |
525 | nFTSVHLSYVE | 2014(33); |
525 | nFTSVHLSYVELK | 2013(40); 2014(33); 2015(unpublished);2015(1); 2015(2); |
636 | nNSMCTTMR | 2013(40); 2015(1); |
739 | TTnSSAADPR | 2013(40); 2014(14); 2014(15); 2014(16); 2014(17); 2014(22); 2014(33); 2015(unpublished); |
739 | IDKGVKTTnSSAADPREY | 2014(33); |
739 | IDKGVKTTnSSAADPREYL | 2014(33); |
914 | NnISLVK | 2013(40); 2014(13); 2014(22); 2014(33); 2015(2); 2015(unpublished); |
980 | HPSCVnVSK | 2012(48); 2013(40); 2014(16); 2014(22); 2015(12); |
980 | LIRHPSCVnVSKW | 2014(33); |
980 | RHPSCVnVSKWNA | 2013(37); |
1005 | nLSMTITR | 2015(1); |
1005 | STQnLSMTITR | 2014(33); |
1078 | CYPSnTSFQVTF | 2014(33); |
1078 | nTSFQVTFGYLQR | 2015(1); |
1078 | VGLCYPSnTSFQVTFGYLQRQNGSLSK | 2013(38); |
1092 | VGLCYPSNTSFQVTFGYLQRQnGSLSK | 2013(38); |
1234 | GDPSVISVnGTDF | 2014(33); |
1234 | GDPSVISVnGTDFTFR | 2007(75); 2011(58); 2012(48); 2012(52); 2013(34); 2013(40); 2014(14); 2014(15); 2014(16); 2014(18); 2014(32); 2014(32); 2014(33); 2015(1); 2015(12); 2015(unpublished);2015(Unpublished ); 2007;2007 ; |
1234 | QSPDKAETQRGDPSVISVnGTDF | 2014(33); |
1299 | QLnISHLLVPL | 2014(33); |
1299 | QLnISHLLVPLGLAK | 2014(33); 2015(unpublished); |
1299 | QInISHIIVPIGIAKPAHIYDK | 2014(16); |
1 | 11 | 21 | 31 | 41 | 51 | 61 | 71 | 81 | 91 |
MYATDSRGHS | PAFLQPQNGN | SRHPSGYVPG | KVVPLRPPPP | PKSQASAKFT | SIRREDRATF | AFSPEEQQAQ | RESQKQKRHK | NTFICFAITS | FSFFIALAII |
101 | 111 | 121 | 131 | 141 | 151 | 161 | 171 | 181 | 191 |
LGISSKYAPD | ENCPDQNPRL | RNWDPGQDSA | KQVVIKEGDM | LRLTSDATVH | SIVIQDGGLL | VFGDNKDGSR | NITLRTHYIL | IQDGGALHIG | AEKCRYKSKA |
201 | 211 | 221 | 231 | 241 | 251 | 261 | 271 | 281 | 291 |
TITLYGKSDE | GESMPTFGKK | FIGVEAGGTL | ELHGARKASW | TLLARTLNSS | GLPFGSYTFE | KDFSRGLNVR | VIDQDTAKIL | ESERFDTHEY | RNESRRLQEF |
301 | 311 | 321 | 331 | 341 | 351 | 361 | 371 | 381 | 391 |
LRFQDPGRIV | AIAVGDSAAK | SLLQGTIQMI | QERLGSELIQ | GLGYRQAWAL | VGVIDGGSTS | CNESVRNYEN | HSSGGKALAQ | REFYTVDGQK | FSVTAYSEWI |
401 | 411 | 421 | 431 | 441 | 451 | 461 | 471 | 481 | 491 |
EGVSLSGFRV | EVVDGVKLNL | LDDVSSWKPG | DQIVVASTDY | SMYQAEEFTL | LPCSECSHFQ | VKVKETPQFL | HMGEIIDGVD | MRAEVGILTR | NIVIQGEVED |
501 | 511 | 521 | 531 | 541 | 551 | 561 | 571 | 581 | 591 |
SCYAENQCQF | FDYDTFGGHI | MIMKNFTSVH | LSYVELKHMG | QQQMGRYPVH | FHLCGDVDYK | GGYRHATFVD | GLSIHHSFSR | CITVHGTNGL | LIKDTIGFDT |
601 | 611 | 621 | 631 | 641 | 651 | 661 | 671 | 681 | 691 |
LGHCFFLEDG | IEQRNTLFHN | LGLLTKPGTL | LPTDRNNSMC | TTMRDKVFGN | YIPVPATDCM | AVSTFWIAHP | NNNLINNAAA | GSQDAGIWYL | FHKEPTGESS |
701 | 711 | 721 | 731 | 741 | 751 | 761 | 771 | 781 | 791 |
GLQLLAKPEL | TPLGIFYNNR | VHSNFKAGLF | IDKGVKTTNS | SAADPREYLC | LDNSARFRPH | QDANPEKPRV | AALIDRLIAF | KNNDNGAWVR | GGDIIVQNSA |
801 | 811 | 821 | 831 | 841 | 851 | 861 | 871 | 881 | 891 |
FADNGIGLTF | ASDGSFPSDE | GSSQEVSESL | FVGESRNYGF | QGGQNKYVGT | GGIDQKPRTL | PRNRTFPIRG | FQIYDGPIHL | TRSTFKKYVP | TPDRYSSAIG |
901 | 911 | 921 | 931 | 941 | 951 | 961 | 971 | 981 | 991 |
FLMKNSWQIT | PRNNISLVKF | GPHVSLNVFF | GKPGPWFEDC | EMDGDKNSIF | HDIDGSVTGY | KDAYVGRMDN | YLIRHPSCVN | VSKWNAVICS | GTYAQVYVQT |
1001 | 1011 | 1021 | 1031 | 1041 | 1051 | 1061 | 1071 | 1081 | 1091 |
WSTQNLSMTI | TRDEYPSNPM | VLRGINQKAA | FPQYQPVVML | EKGYTIHWNG | PAPRTTFLYL | VNFNKNDWIR | VGLCYPSNTS | FQVTFGYLQR | QNGSLSKIEE |
1101 | 1111 | 1121 | 1131 | 1141 | 1151 | 1161 | 1171 | 1181 | 1191 |
YEPVHSLEEL | QRKQSERKFY | FDSSTGLLFL | YLKAKSHRHG | HSYCSSQGCE | RVKIQAATDS | KDISNCMAKA | YPQYYRKPSV | VKRMPAMLTG | LCQGCGTRQV |
1201 | 1211 | 1221 | 1231 | 1241 | 1251 | 1261 | 1271 | 1281 | 1291 |
VFTSDPHKSY | LPVQFQSPDK | AETQRGDPSV | ISVNGTDFTF | RSAGVLLLVV | DPCSVPFRLT | EKTVFPLADV | SRIEEYLKTG | IPPRSIVLLS | TRGEIKQLNI |
1301 | 1311 | 1321 | 1331 | 1341 | 1351 | 1361 | 1371 | 1381 | |
SHLLVPLGLA | KPAHLYDKGS | TIFLGFSGNF | KPSWTKLFTS | PAGQGLGVLE | QFIPLQLDEY | GCPRATTVRR | RDLELLKQAS | KAH |
ID | Publication |
---|---|
1 | Sun S, Shah P, Eshghi ST, Yang W, Trikannad N, Yang S, Chen L, Aiyetan P, Hoti N, Zhang Z, et al: Comprehensive analysis of protein glycosylation by solid-phase extraction of N-linked glycans and glycosite-containing peptides. Nat Biotech 2015, advance online publication. |
2 | Shah P, Wang X, Yang W, Eshghi ST, Sun S, Hoti N, Chen L, Yang S, Pasay J, Rubin A: Integrated Proteomic and Glycoproteomic Analyses of Prostate Cancer Cells Reveal Glycoprotein Alteration in Protein Abundance and Glycosylation. Molecular & Cellular Proteomics 2015, 14:2753-2763. |
12 | Weng Y, Sui Z, Jiang H, Shan Y, Chen L, Zhang S, Zhang L, Zhang Y: Releasing N-glycan from Peptide N-terminus by N-terminal Succinylation Assisted Enzymatic Deglycosylation. Scientific Reports 2015, 5. |
13 | Yang W, Laeyendecker O, Wendel SK, Zhang B, Sun S, Zhou J-Y, Ao M, Moore RD, Jackson JB, Zhang H: Glycoproteomic Study Reveals Altered Plasma Proteins Associated with HIV Elite Suppressors. Theranostics 2014, 4:1153. |
14 | Liu Y, Chen J, Sethi A, Li QK, Chen L, Collins B, Gillet LC, Wollscheid B, Zhang H, Aebersold R: Glycoproteomic analysis of prostate cancer tissues by SWATH mass spectrometry discovers N-acylethanolamine acid amidase and protein tyrosine kinase 7 as signatures for tumor aggressiveness. Molecular & Cellular Proteomics 2014, 13:1753-1768. |
15 | Chen R, Seebun D, Ye M, Zou H, Figeys D: Site-specific characterization of cell membrane N-glycosylation with integrated hydrophilic interaction chromatography solid phase extraction and LC-MS/MS. Journal of Proteomics 2014, 103:194-203. |
16 | Deeb SJ, Cox J, Schmidt-Supprian M, Mann M: N-linked Glycosylation Enrichment for In-depth Cell Surface Proteomics of Diffuse Large B-cell Lymphoma Subtypes. Molecular & Cellular Proteomics 2014, 13:240-251. |
17 | Fang C, Xiong Z, Qin H, Huang G, Liu J, Ye M, Feng S, Zou H: One-pot synthesis of magnetic colloidal nanocrystal clusters coated with chitosan for selective enrichment of glycopeptides. Analytica Chimica Acta 2014, 841:99-105. |
18 | Hirao Y, Matsuzaki H, Iwaki J, Kuno A, Kaji H, Ohkura T, Togayachi A, Abe M, Nomura M, Noguchi M, et al: Glycoproteomics Approach for Identifying Glycobiomarker Candidate Molecules for Tissue Type Classification of Non-small Cell Lung Carcinoma. Journal of Proteome Research 2014, 13:4705-4716. |
22 | Nicastri A, Gaspari M, Sacco R, Elia L, Gabriele C, Romano R, Rizzuto A, Cuda G: N-Glycoprotein Analysis Discovers New Up-Regulated Glycoproteins in Colorectal Cancer Tissue. Journal of Proteome Research 2014, 13:4932-4941. |
32 | Zhang Z, Sun Z, Zhu J, Liu J, Huang G, Ye M, Zou H: High-Throughput Determination of the Site-Specific N-Sialoglycan Occupancy Rates by Differential Oxidation of Glycoproteins Followed with Quantitative Glycoproteomics Analysis. Analytical Chemistry 2014, 86:9830-9837. |
33 | Zhu J, Sun Z, Cheng K, Chen R, Ye M, Xu B, Sun D, Wang L, Liu J, Wang F, Zou H: Comprehensive Mapping of Protein N-Glycosylation in Human Liver by Combining Hydrophilic Interaction Chromatography and Hydrazide Chemistry. Journal of Proteome Research 2014, 13:1713-1721. |
34 | Sun S, Zhang B, Aiyetan P, Zhou J-Y, Shah P, Yang W, Levine DA, Zhang Z, Chan DW, Zhang H: Analysis of N-glycoproteins using Genomic N-glycosite Prediction. Journal of Proteome Research 2013, 12:5609-5615. |
37 | Boersema PJ, Geiger T, Wisniewski JR, Mann M: Quantification of the N-glycosylated Secretome by Super-SILAC During Breast Cancer Progression and in Human Blood Samples. Molecular & Cellular Proteomics 2013, 12:158-171. |
38 | Kaji H, Ocho M, Togayachi A, Kuno A, Sogabe M, Ohkura T, Nozaki H, Angata T, Chiba Y, Ozaki H, et al: Glycoproteomic Discovery of Serological Biomarker Candidates for HCV/HBV Infection-Associated Liver Fibrosis and Hepatocellular Carcinoma. Journal of Proteome Research 2013, 12:2630-2640. |
40 | Li X, Jiang J, Zhao X, Wang J, Han H, Zhao Y, Peng B, Zhong R, Ying W, Qian X: N-glycoproteome Analysis of the Secretome of Human Metastatic Hepatocellular Carcinoma Cell Lines Combining Hydrazide Chemistry, HILIC Enrichment and Mass Spectrometry. Plos One 2013, 8. |
48 | Danzer C, Eckhardt K, Schmidt A, Fankhauser N, Ribrioux S, Wollscheid B, Mueller L, Schiess R, Zuellig R, Lehmann R, et al: Comprehensive Description of the N-Glycoproteome of Mouse Pancreatic beta-Cells and Human Islets. Journal of Proteome Research 2012, 11:1598-1608. |
52 | Yen T-Y, Macher BA, McDonald CA, Alleyne-Chin C, Timpe LC: Glycoprotein Profiles of Human Breast Cells Demonstrate a Clear Clustering of Normal/Benign versus Malignant Cell Lines and Basal versus Luminal Cell Lines. Journal of Proteome Research 2012, 11:656-667. |
58 | Nagano K, Shinkawa T, Kato K, Inomata N, Yabuki N, Haramura M: Distinct cell surface proteome profiling by biotin labeling and glycoprotein capturing. Journal of Proteomics 2011, 74:1985-1993. |
75 | Sun B, Ranish JA, Utleg AG, White JT, Yan X, Lin B, Hood L: Shotgun glycopeptide capture approach coupled with mass Spectrometry for comprehensive glycoproteomics. Molecular & Cellular Proteomics 2007, 6:141-149. |