Detail

UniProtKB-Q9UHW9


Protein	Solute carrier family 12 member 6
Gene	SLC12A6
Status	Reviewed
Source	Colorectal tumor; Colorectal tumors; DLBCL cell lines (Diffuse large B-cell lymphoma); Jurkat T cell line; LNCap/PC3 cell lines (Prostate cancer); Liver; OVCAR-3 cell line (Ovarian cancer)
Years	2009-2015

Glycosites

Site	Identified Peptides	Year(Publication ID)
379	SSFAPPHFPVCMIGnR	2014(16);
398	nMTVPSK	2015(1);
398	EINnMTVPSK	2009(68); 2014(13); 2014(22);
398	TKEINnMTVPSK	2014(13); 2015(2);
417	nATCDEYFVHN	2015(1);
428	YFVHNnVTSIQGIPGLASGIITE	2014(33);

Sequence

1	11	21	31	41	51	61	71	81	91
MHPPETTTKM	ASVRFMVTPT	KIDDIPGLSD	TSPDLSSRSS	SRVRFSSRES	VPETSRSEPM	SEMSGATTSL	ATVALDPPSD	RTSHPQDVIE	DLSQNSITGE
101	111	121	131	141	151	161	171	181	191
HSQLLDDGHK	KARNAYLNNS	NYEEGDEYFD	KNLALFEEEM	DTRPKVSSLL	NRMANYTNLT	QGAKEHEEAE	NITEGKKKPT	KTPQMGTFMG	VYLPCLQNIF
201	211	221	231	241	251	261	271	281	291
GVILFLRLTW	VVGTAGVLQA	FAIVLICCCC	TMLTAISMSA	IATNGVVPAG	GSYFMISRAL	GPEFGGAVGL	CFYLGTTFAA	AMYILGAIEI	FLVYIVPRAA
301	311	321	331	341	351	361	371	381	391
IFHSDDALKE	SAAMLNNMRV	YGTAFLVLMV	LVVFIGVRYV	NKFASLFLAC	VIVSILAIYA	GAIKSSFAPP	HFPVCMLGNR	TLSSRHIDVC	SKTKEINNMT
401	411	421	431	441	451	461	471	481	491
VPSKLWGFFC	NSSQFFNATC	DEYFVHNNVT	SIQGIPGLAS	GIITENLWSN	YLPKGEIIEK	PSAKSSDVLG	SLNHEYVLVD	ITTSFTLLVG	IFFPSVTGIM
501	511	521	531	541	551	561	571	581	591
AGSNRSGDLK	DAQKSIPIGT	ILAILTTSFV	YLSNVVLFGA	CIEGVVLRDK	FGDAVKGNLV	VGTLSWPSPW	VIVIGSFFST	CGAGLQSLTG	APRLLQAIAK
601	611	621	631	641	651	661	671	681	691
DNIIPFLRVF	GHSKANGEPT	WALLLTAAIA	ELGILIASLD	LVAPILSMFF	LMCYLFVNLA	CALQTLLRTP	NWRPRFRYYH	WALSFMGMSI	CLALMFISSW
701	711	721	731	741	751	761	771	781	791
YYAIVAMVIA	GMIYKYIEYQ	GAEKEWGDGI	RGLSLSAARF	ALLRLEEGPP	HTKNWRPQLL	VLLKLDEDLH	VKHPRLLTFA	SQLKAGKGLT	IVGSVIVGNF
801	811	821	831	841	851	861	871	881	891
LENYGEALAA	EQTIKHLMEA	EKVKGFCQLV	VAAKLREGIS	HLIQSCGLGG	MKHNTVVMGW	PNGWRQSEDA	RAWKTFIGTV	RVTTAAHLAL	LVAKNISFFP
901	911	921	931	941	951	961	971	981	991
SNVEQFSEGN	IDVWWIVHDG	GMLMLLPFLL	KQHKVWRKCS	IRIFTVAQLE	DNSIQMKKDL	ATFLYHLRIE	AEVEVVEMHD	SDISAYTYER	TLMMEQRSQM
1001	1011	1021	1031	1041	1051	1061	1071	1081	1091
LRHMRLSKTE	RDREAQLVKD	RNSMLRLTSI	GSDEDEETET	YQEKVHMTWT	KDKYMASRGQ	KAKSMEGFQD	LLNMRPDQSN	VRRMHTAVKL	NEVIVNKSHE
1101	1111	1121	1131	1141
AKLVLLNMPG	PPRNPEGDEN	YMEFLEVLTE	GLERVLLVRG	GGSEVITIYS

Reference

ID	Publication
1	Sun S, Shah P, Eshghi ST, Yang W, Trikannad N, Yang S, Chen L, Aiyetan P, Hoti N, Zhang Z, et al: Comprehensive analysis of protein glycosylation by solid-phase extraction of N-linked glycans and glycosite-containing peptides. Nat Biotech 2015, advance online publication.
2	Shah P, Wang X, Yang W, Eshghi ST, Sun S, Hoti N, Chen L, Yang S, Pasay J, Rubin A: Integrated Proteomic and Glycoproteomic Analyses of Prostate Cancer Cells Reveal Glycoprotein Alteration in Protein Abundance and Glycosylation. Molecular & Cellular Proteomics 2015, 14:2753-2763.
13	Yang W, Laeyendecker O, Wendel SK, Zhang B, Sun S, Zhou J-Y, Ao M, Moore RD, Jackson JB, Zhang H: Glycoproteomic Study Reveals Altered Plasma Proteins Associated with HIV Elite Suppressors. Theranostics 2014, 4:1153.
16	Deeb SJ, Cox J, Schmidt-Supprian M, Mann M: N-linked Glycosylation Enrichment for In-depth Cell Surface Proteomics of Diffuse Large B-cell Lymphoma Subtypes. Molecular & Cellular Proteomics 2014, 13:240-251.
22	Nicastri A, Gaspari M, Sacco R, Elia L, Gabriele C, Romano R, Rizzuto A, Cuda G: N-Glycoprotein Analysis Discovers New Up-Regulated Glycoproteins in Colorectal Cancer Tissue. Journal of Proteome Research 2014, 13:4932-4941.
33	Zhu J, Sun Z, Cheng K, Chen R, Ye M, Xu B, Sun D, Wang L, Liu J, Wang F, Zou H: Comprehensive Mapping of Protein N-Glycosylation in Human Liver by Combining Hydrophilic Interaction Chromatography and Hydrazide Chemistry. Journal of Proteome Research 2014, 13:1713-1721.
68	Zhang L, Xu Y, Yao H, Xie L, Yao J, Lu H, Yang P: Boronic Acid Functionalized Core-Satellite Composite Nanoparticles for Advanced Enrichment of Glycopeptides and Glycoproteins. Chemistry-a European Journal 2009, 15:10158-10166.