Detail


Protein	Neurogenic locus notch homolog protein 3
Gene	NOTCH3
Status	Reviewed
Source	Breast Cancer cell lines; Breast cancer xenografts; OVCAR-3 cell line (Ovarian cancer)
Years	2013-2015

Site	Identified Peptides	Year(Publication ID)
1179	nGTCVDLVGGFR	2015(1);
1179	GPRCIHnGTCVDI	2013(37);
1179	CLHnGTCVDLVGGFR	2015(unpublished);
1438	LFnNSR	2015(unpublished);

Sequence

1	11	21	31	41	51	61	71	81	91
MGPGARGRRR	RRRPMSPPPP	PPPVRALPLL	LLLAGPGAAA	PPCLDGSPCA	NGGRCTQLPS	REAACLCPPG	WVGERCQLED	PCHSGPCAGR	GVCQSSVVAG
101	111	121	131	141	151	161	171	181	191
TARFSCRCPR	GFRGPDCSLP	DPCLSSPCAH	GARCSVGPDG	RFLCSCPPGY	QGRSCRSDVD	ECRVGEPCRH	GGTCLNTPGS	FRCQCPAGYT	GPLCENPAVP
201	211	221	231	241	251	261	271	281	291
CAPSPCRNGG	TCRQSGDLTY	DCACLPGFEG	QNCEVNVDDC	PGHRCLNGGT	CVDGVNTYNC	QCPPEWTGQF	CTEDVDECQL	QPNACHNGGT	CFNTLGGHSC
301	311	321	331	341	351	361	371	381	391
VCVNGWTGES	CSQNIDDCAT	AVCFHGATCH	DRVASFYCAC	PMGKTGLLCH	LDDACVSNPC	HEDAICDTNP	VNGRAICTCP	PGFTGGACDQ	DVDECSIGAN
401	411	421	431	441	451	461	471	481	491
PCEHLGRCVN	TQGSFLCQCG	RGYTGPRCET	DVNECLSGPC	RNQATCLDRI	GQFTCICMAG	FTGTYCEVDI	DECQSSPCVN	GGVCKDRVNG	FSCTCPSGFS
501	511	521	531	541	551	561	571	581	591
GSTCQLDVDE	CASTPCRNGA	KCVDQPDGYE	CRCAEGFEGT	LCDRNVDDCS	PDPCHHGRCV	DGIASFSCAC	APGYTGTRCE	SQVDECRSQP	CRHGGKCLDL
601	611	621	631	641	651	661	671	681	691
VDKYLCRCPS	GTTGVNCEVN	IDDCASNPCT	FGVCRDGINR	YDCVCQPGFT	GPLCNVEINE	CASSPCGEGG	SCVDGENGFR	CLCPPGSLPP	LCLPPSHPCA
701	711	721	731	741	751	761	771	781	791
HEPCSHGICY	DAPGGFRCVC	EPGWSGPRCS	QSLARDACES	QPCRAGGTCS	SDGMGFHCTC	PPGVQGRQCE	LLSPCTPNPC	EHGGRCESAP	GQLPVCSCPQ
801	811	821	831	841	851	861	871	881	891
GWQGPRCQQD	VDECAGPAPC	GPHGICTNLA	GSFSCTCHGG	YTGPSCDQDI	NDCDPNPCLN	GGSCQDGVGS	FSCSCLPGFA	GPRCARDVDE	CLSNPCGPGT
901	911	921	931	941	951	961	971	981	991
CTDHVASFTC	TCPPGYGGFH	CEQDLPDCSP	SSCFNGGTCV	DGVNSFSCLC	RPGYTGAHCQ	HEADPCLSRP	CLHGGVCSAA	HPGFRCTCLE	SFTGPQCQTL
1001	1011	1021	1031	1041	1051	1061	1071	1081	1091
VDWCSRQPCQ	NGGRCVQTGA	YCLCPPGWSG	RLCDIRSLPC	REAAAQIGVR	LEQLCQAGGQ	CVDEDSSHYC	VCPEGRTGSH	CEQEVDPCLA	QPCQHGGTCR
1101	1111	1121	1131	1141	1151	1161	1171	1181	1191
GYMGGYMCEC	LPGYNGDNCE	DDVDECASQP	CQHGGSCIDL	VARYLCSCPP	GTLGVLCEIN	EDDCGPGPPL	DSGPRCLHNG	TCVDLVGGFR	CTCPPGYTGL
1201	1211	1221	1231	1241	1251	1261	1271	1281	1291
RCEADINECR	SGACHAAHTR	DCLQDPGGGF	RCLCHAGFSG	PRCQTVLSPC	ESQPCQHGGQ	CRPSPGPGGG	LTFTCHCAQP	FWGPRCERVA	RSCRELQCPV
1301	1311	1321	1331	1341	1351	1361	1371	1381	1391
GVPCQQTPRG	PRCACPPGLS	GPSCRSFPGS	PPGASNASCA	AAPCLHGGSC	RPAPLAPFFR	CACAQGWTGP	RCEAPAAAPE	VSEEPRCPRA	ACQAKRGDQR
1401	1411	1421	1431	1441	1451	1461	1471	1481	1491
CDRECNSPGC	GWDGGDCSLS	VGDPWRQCEA	LQCWRLFNNS	RCDPACSSPA	CLYDNFDCHA	GGRERTCNPV	YEKYCADHFA	DGRCDQGCNT	EECGWDGLDC
1501	1511	1521	1531	1541	1551	1561	1571	1581	1591
ASEVPALLAR	GVLVLTVLLP	PEELLRSSAD	FLQRLSAILR	TSLRFRLDAH	GQAMVFPYHR	PSPGSEPRAR	RELAPEVIGS	VVMLEIDNRL	CLQSPENDHC
1601	1611	1621	1631	1641	1651	1661	1671	1681	1691
FPDAQSAADY	LGALSAVERL	DFPYPLRDVR	GEPLEPPEPS	VPLLPLLVAG	AVLLLVILVL	GVMVARRKRE	HSTLWFPEGF	SLHKDVASGH	KGRREPVGQD
1701	1711	1721	1731	1741	1751	1761	1771	1781	1791
ALGMKNMAKG	ESLMGEVATD	WMDTECPEAK	RLKVEEPGMG	AEEAVDCRQW	TQHHLVAADI	RVAPAMALTP	PQGDADADGM	DVNVRGPDGF	TPLMLASFCG
1801	1811	1821	1831	1841	1851	1861	1871	1881	1891
GALEPMPTEE	DEADDTSASI	ISDLICQGAQ	LGARTDRTGE	TALHLAARYA	RADAAKRLLD	AGADTNAQDH	SGRTPLHTAV	TADAQGVFQI	LIRNRSTDLD
1901	1911	1921	1931	1941	1951	1961	1971	1981	1991
ARMADGSTAL	ILAARLAVEG	MVEELIASHA	DVNAVDELGK	SALHWAAAVN	NVEATLALLK	NGANKDMQDS	KEETPLFLAA	REGSYEAAKL	LLDHFANREI
2001	2011	2021	2031	2041	2051	2061	2071	2081	2091
TDHLDRLPRD	VAQERLHQDI	VRLLDQPSGP	RSPPGPHGLG	PLLCPPGAFL	PGLKAAQSGS	KKSRRPPGKA	GLGPQGPRGR	GKKLTLACPG	PLADSSVTLS
2101	2111	2121	2131	2141	2151	2161	2171	2181	2191
PVDSLDSPRP	FGGPPASPGG	FPLEGPYAAA	TATAVSLAQL	GGPGRAGLGR	QPPGGCVLSL	GLLNPVAVPL	DWARLPPPAP	PGPSFLLPLA	PGPQLLNPGT
2201	2211	2221	2231	2241	2251	2261	2271	2281	2291
PVSPQERPPP	YLAVPGHGEE	YPAAGAHSSP	PKARFLRVPS	EHPYLTPSPE	SPEHWASPSP	PSLSDWSEST	PSPATATGAM	ATTTGALPAQ	PLPLSVPSSL
2301	2311	2321
AQAQTQLGPQ	PEVTPKRQVL	A

UniProtKB-Q9UM47

Glycosites

Sequence

Reference

ID	Publication
1	Sun S, Shah P, Eshghi ST, Yang W, Trikannad N, Yang S, Chen L, Aiyetan P, Hoti N, Zhang Z, et al: Comprehensive analysis of protein glycosylation by solid-phase extraction of N-linked glycans and glycosite-containing peptides. Nat Biotech 2015, advance online publication.
37	Boersema PJ, Geiger T, Wisniewski JR, Mann M: Quantification of the N-glycosylated Secretome by Super-SILAC During Breast Cancer Progression and in Human Blood Samples. Molecular & Cellular Proteomics 2013, 12:158-171.