| Protein | Heparanase |
| Gene | HPSE |
| Status | Reviewed |
| Source | ARO Cell Line (Thyroid Cance); Breast cancer xenografts; Breast cell lines; DLBCL cell lines (Diffuse large B-cell lymphoma); Human; LNCap/PC3 cell lines (Prostate cancer); Liver; OVCAR-3 cell line (Ovarian cancer); Ovarian cancer cell lines; Ovarian tumor; Platelet; Prostate tumor; Urine |
| Years | 2007-2015 |
| Site | Identified Peptides | Year(Publication ID) |
|---|---|---|
| 162 | FKnSTYSR | 2014(16); 2015(2); |
| 178 | SSVDVLYTFAnCSGLDLIFGLNALLR | 2015(unpublished); |
| 200 | nSSNAQLLLDYCSSK | 2015(1); |
| 200 | TADLQWnSSNAQLLLDYCSSK | 2015(unpublished); |
| 217 | GYnISWEIGNEPNSFIK | 2014(16); |
| 217 | GYnISWELGNEPNSFLK | 2009(62); 2009(64); 2012(52); 2014(33); 2015(1); 2015(unpublished);2015(2); |
| 217 | GYnISWELGNEPNSFLKK | 2015(unpublished); |
| 238 | ADIFInGSQLGEDFIQLHK | 2015(unpublished);2015(1); 2015(unpublished);2015(2); |
| 238 | KADIFInGSQIGEDFIQIHK | 2014(16); |
| 238 | KADIFInGSQLGEDFIQLHK | 2007(64); 2009(33); 2014(1); 2015(2); 2015(unpublished);2015(unpublished);2015;2007;2007; |
| 238 | SFLKKADIFInGSQLGEDFI | 2015(6); |
| 459 | AINLHnVTKY | 2014(33); |
| 459 | EGDLTLYAINLHnVTK | 2015(unpublished);2015(unpublished);2015(unpublished); |
| 459 | YKEGDITIYAINIHnVTK | 2014(16); |
| 459 | YKEGDLTLYAINLHnVTK | 2015(1); 2015(unpublished);2007(unpublished);2007(unpublished);2007; |
| 1 | 11 | 21 | 31 | 41 | 51 | 61 | 71 | 81 | 91 |
| MLLRSKPALP | PPLMLLLLGP | LGPLSPGALP | RPAQAQDVVD | LDFFTQEPLH | LVSPSFLSVT | IDANLATDPR | FLILLGSPKL | RTLARGLSPA | YLRFGGTKTD |
| 101 | 111 | 121 | 131 | 141 | 151 | 161 | 171 | 181 | 191 |
| FLIFDPKKES | TFEERSYWQS | QVNQDICKYG | SIPPDVEEKL | RLEWPYQEQL | LLREHYQKKF | KNSTYSRSSV | DVLYTFANCS | GLDLIFGLNA | LLRTADLQWN |
| 201 | 211 | 221 | 231 | 241 | 251 | 261 | 271 | 281 | 291 |
| SSNAQLLLDY | CSSKGYNISW | ELGNEPNSFL | KKADIFINGS | QLGEDFIQLH | KLLRKSTFKN | AKLYGPDVGQ | PRRKTAKMLK | SFLKAGGEVI | DSVTWHHYYL |
| 301 | 311 | 321 | 331 | 341 | 351 | 361 | 371 | 381 | 391 |
| NGRTATKEDF | LNPDVLDIFI | SSVQKVFQVV | ESTRPGKKVW | LGETSSAYGG | GAPLLSDTFA | AGFMWLDKLG | LSARMGIEVV | MRQVFFGAGN | YHLVDENFDP |
| 401 | 411 | 421 | 431 | 441 | 451 | 461 | 471 | 481 | 491 |
| LPDYWLSLLF | KKLVGTKVLM | ASVQGSKRRK | LRVYLHCTNT | DNPRYKEGDL | TLYAINLHNV | TKYLRLPYPF | SNKQVDKYLL | RPLGPHGLLS | KSVQLNGLTL |
| 501 | 511 | 521 | 531 | 541 | |||||
| KMVDDQTLPP | LMEKPLRPGS | SLGLPAFSYS | FFVIRNAKVA | ACI |
| ID | Publication |
|---|---|
| 1 | Sun S, Shah P, Eshghi ST, Yang W, Trikannad N, Yang S, Chen L, Aiyetan P, Hoti N, Zhang Z, et al: Comprehensive analysis of protein glycosylation by solid-phase extraction of N-linked glycans and glycosite-containing peptides. Nat Biotech 2015, advance online publication. |
| 2 | Shah P, Wang X, Yang W, Eshghi ST, Sun S, Hoti N, Chen L, Yang S, Pasay J, Rubin A: Integrated Proteomic and Glycoproteomic Analyses of Prostate Cancer Cells Reveal Glycoprotein Alteration in Protein Abundance and Glycosylation. Molecular & Cellular Proteomics 2015, 14:2753-2763. |
| 6 | Kim DS, Hahn Y: The acquisition of novel N-glycosylation sites in conserved proteins during human evolution. Bmc Bioinformatics 2015, 16. |
| 16 | Deeb SJ, Cox J, Schmidt-Supprian M, Mann M: N-linked Glycosylation Enrichment for In-depth Cell Surface Proteomics of Diffuse Large B-cell Lymphoma Subtypes. Molecular & Cellular Proteomics 2014, 13:240-251. |
| 33 | Zhu J, Sun Z, Cheng K, Chen R, Ye M, Xu B, Sun D, Wang L, Liu J, Wang F, Zou H: Comprehensive Mapping of Protein N-Glycosylation in Human Liver by Combining Hydrophilic Interaction Chromatography and Hydrazide Chemistry. Journal of Proteome Research 2014, 13:1713-1721. |
| 52 | Yen T-Y, Macher BA, McDonald CA, Alleyne-Chin C, Timpe LC: Glycoprotein Profiles of Human Breast Cells Demonstrate a Clear Clustering of Normal/Benign versus Malignant Cell Lines and Basal versus Luminal Cell Lines. Journal of Proteome Research 2012, 11:656-667. |
| 62 | Arcinas A, Yen T-Y, Kebebew E, Macher BA: Cell Surface and Secreted Protein Profiles of Human Thyroid Cancer Cell Lines Reveal Distinct Glycoprotein Patterns. Journal of Proteome Research 2009, 8:3958-3968. |
| 64 | Chen R, Jiang X, Sun D, Han G, Wang F, Ye M, Wang L, Zou H: Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry. J Proteome Res 2009, 8:651-661. |