| Protein | Epididymis-specific alpha-mannosidase |
| Gene | MAN2B2 |
| Status | Reviewed |
| Source | ARO Cell Line (Thyroid Cance); Breast Cancer cell lines; Breast cancer cell lines; Breast cancer xenografts; Breast cell lines; Breast tumor; Cerebrospinal fluid; DLBCL cell lines (Diffuse large B-cell lymphoma); HCC cell lines (Liver); Hela cell line (cervical cancer); HuH-7 cell line (Liver); LNCap/PC3 cell lines (Prostate cancer); Liver; Liver tumor (HCC); Non-small Cell Lung Carcinoma; OVCAR-3 cell line (Ovarian cancer); Ovarian tumor; Pancreatic islets; Prostate; Prostate cancer metastasis to liver; Prostate tumor; Serum; TPC-1 Cell Line (Thyroid Cance); Urine; UrineJurkat T cell line; XTC-1 Cell Line (Thyroid Cance); XTC-1 Cell Line (Thyroid Cance)Jurkat T cell line |
| Years | 2007-2015 |
| Site | Identified Peptides | Year(Publication ID) |
|---|---|---|
| 226 | SYCTPSHIPFSnR | 2014(33); |
| 226 | QEIFTHIMDQYSYCTPSHIPFSnR | 2009(62); 2009(62); 2009(62); 2014(16); |
| 249 | SGFYWNGVAVFPKPPQDGVYPnMSEPVTPANINLYAEALVANVK | 2015(unpublished); |
| 336 | AIHAInVTWR | 2014(16); 2014(32); |
| 336 | ALHALnVTWR | 2007(62); 2009(62); 2009(40); 2013(33); 2014(1); 2015(2); 2015(unpublished);2015(unpublished);2015;2015;2015;2007;2007; |
| 336 | RAIHAInVTWRVR | 2013(37); |
| 516 | AGHPVPSQIQnSTETPSAY | 2014(33); |
| 516 | AGHPVPSQIQnSTETPSAYD | 2014(33); |
| 516 | VTDEAGHPVPSQIQnSTETPSAY | 2014(33); |
| 516 | TVGFPGVRVTDEAGHPVPSQIQnSTETPSAY | 2014(33); |
| 516 | VTDEAGHPVPSQIQnSTETPSAYDIIIITTIPGISYR | 2014(32); 2014(32); |
| 516 | VTDEAGHPVPSQIQnSTETPSAYDLLILTTIPGLSYR | 2007(62); 2009(64); 2009(52); 2012(33); 2014(1); 2015(2); 2015(12); 2015(unpublished);2015(unpublished);2007(unpublished);2007(unpublished);2007(Unpublished ); 2007;2007 ; |
| 670 | YRnMTAQNY | 2014(33); |
| 670 | FYRnMTAQNY | 2014(33); |
| 670 | nMTAQNYTYAIR | 2007(62); 2009(62); 2009(13); 2014(14); 2014(33); 2014(2); 2015(unpublished);2015(unpublished);2015;2015;2015;2015;2007;2007; |
| 675 | nYTYAIR | 2015(1); |
| 675 | YRNMTAQnY | 2014(33); |
| 675 | FYRNMTAQnY | 2014(33); |
| 675 | NMTAQnYTYAIR | 2007(62); 2009(62); 2009(13); 2014(14); 2014(33); 2014(2); 2015(unpublished);2015(unpublished);2015;2015;2015;2015;2007;2007; |
| 748 | RPYVSYVnN | 2014(33); |
| 748 | VnNSIARNY | 2014(33); |
| 748 | VSYVnNSIAR | 2014(33); |
| 748 | VSYVnNSIARN | 2014(33); |
| 748 | YVSYVnNSIAR | 2014(14); 2015(unpublished); |
| 748 | VSYVnNSIARNY | 2014(33); |
| 748 | PYVSYVnNSIARN | 2013(37); |
| 748 | RPYVSYVnNSIAR | 2007(62); 2009(62); 2009(62); 2009(48); 2012(52); 2012(40); 2013(45); 2013(13); 2014(14); 2014(16); 2014(32); 2014(33); 2014(1); 2015(2); 2015(unpublished);2015(unpublished);2015(unpublished);2015(unpublished);2015(unpublished);2015(unpublished);2015;2007;2007;2007;2007;2007;2007; |
| 748 | QMQRRPYVSYVnNSIAR | 2015(unpublished); |
| 808 | nLTLNDTSVVHPVLW | 2014(33); |
| 812 | TLnDTSVVHPVLW | 2014(33); |
| 812 | NLTLnDTSVVHPVLW | 2014(33); |
| 890 | GWRYSSnHTEHSQ | 2013(37); |
| 890 | YSSnHTEHSQNIR | 2014(16); |
| 890 | YSSnHTEHSQNLR | 2013(38); 2013(40); 2014(18); 2015(unpublished);2015(unpublished);2015(12); |
| 890 | YSSnHTEHSQNLRK | 2013(38); |
| 1 | 11 | 21 | 31 | 41 | 51 | 61 | 71 | 81 | 91 |
| MGQLCWLPLL | APLLLLRPPG | VQSAGPIRAF | VVPHSHMDVG | WVYTVQESMR | AYAANVYTSV | VEELARGQQR | RFIAVEQEFF | RLWWDGVASD | QQKYQVRQLL |
| 101 | 111 | 121 | 131 | 141 | 151 | 161 | 171 | 181 | 191 |
| EEGRLEFVIG | GQVMHDEAVT | HLDDQILQLT | EGHGFLYETF | GIRPQFSWHV | DPFGASATTP | TLFALAGFNA | HLGSRIDYDL | KAAMQEARGL | QFVWRGSPSL |
| 201 | 211 | 221 | 231 | 241 | 251 | 261 | 271 | 281 | 291 |
| SERQEIFTHI | MDQYSYCTPS | HIPFSNRSGF | YWNGVAVFPK | PPQDGVYPNM | SEPVTPANIN | LYAEALVANV | KQRAAWFRTP | HVLWPWGCDK | QFFNASVQFA |
| 301 | 311 | 321 | 331 | 341 | 351 | 361 | 371 | 381 | 391 |
| NMDPLLDHIN | SHAAELGVSV | QYATLGDYFR | ALHALNVTWR | VRDHHDFLPY | STEPFQAWTG | FYTSRSSLKG | LARRASALLY | AGESMFTRYL | WPAPRGHLDP |
| 401 | 411 | 421 | 431 | 441 | 451 | 461 | 471 | 481 | 491 |
| TWALQQLQQL | RWAVSEVQHH | DAITGTESPK | VRDMYATHLA | SGMLGMRKLM | ASIVLDELQP | QAPMAASSDA | GPAGHFASVY | NPLAWTVTTI | VTLTVGFPGV |
| 501 | 511 | 521 | 531 | 541 | 551 | 561 | 571 | 581 | 591 |
| RVTDEAGHPV | PSQIQNSTET | PSAYDLLILT | TIPGLSYRHY | NIRPTAGAQE | GTQEPAATVA | STLQFGRRLR | RRTSHAGRYL | VPVANDCYIV | LLDQDTNLMH |
| 601 | 611 | 621 | 631 | 641 | 651 | 661 | 671 | 681 | 691 |
| SIWERQSNRT | VRVTQEFLEY | HVNGDVKQGP | ISDNYLFTPG | KAAVPAWEAV | EMEIVAGQLV | TEIRQYFYRN | MTAQNYTYAI | RSRLTHVPQG | HDGELLCHRI |
| 701 | 711 | 721 | 731 | 741 | 751 | 761 | 771 | 781 | 791 |
| EQEYQAGPLE | LNREAVLRTS | TNLNSQQVIY | SDNNGYQMQR | RPYVSYVNNS | IARNYYPMVQ | SAFMEDGKSR | LVLLSERAHG | ISSQGNGQVE | VMLHRRLWNN |
| 801 | 811 | 821 | 831 | 841 | 851 | 861 | 871 | 881 | 891 |
| FDWDLGYNLT | LNDTSVVHPV | LWLLLGSWSL | TTALRQRSAL | ALQHRPVVLF | GDLAGTAPKL | PGPQQQEAVT | LPPNLHLQIL | SIPGWRYSSN | HTEHSQNLRK |
| 901 | 911 | 921 | 931 | 941 | 951 | 961 | 971 | 981 | 991 |
| GHRGEAQADL | RRVLLRLYHL | YEVGEDPVLS | QPVTVNLEAV | LQALGSVVAV | EERSLTGTWD | LSMLHRWSWR | TGPGRHRGDT | TSPSRPPGGP | IITVHPKEIR |
| 1001 | |||||||||
| TFFIHFQQQ |
| ID | Publication |
|---|---|
| 1 | Sun S, Shah P, Eshghi ST, Yang W, Trikannad N, Yang S, Chen L, Aiyetan P, Hoti N, Zhang Z, et al: Comprehensive analysis of protein glycosylation by solid-phase extraction of N-linked glycans and glycosite-containing peptides. Nat Biotech 2015, advance online publication. |
| 2 | Shah P, Wang X, Yang W, Eshghi ST, Sun S, Hoti N, Chen L, Yang S, Pasay J, Rubin A: Integrated Proteomic and Glycoproteomic Analyses of Prostate Cancer Cells Reveal Glycoprotein Alteration in Protein Abundance and Glycosylation. Molecular & Cellular Proteomics 2015, 14:2753-2763. |
| 12 | Weng Y, Sui Z, Jiang H, Shan Y, Chen L, Zhang S, Zhang L, Zhang Y: Releasing N-glycan from Peptide N-terminus by N-terminal Succinylation Assisted Enzymatic Deglycosylation. Scientific Reports 2015, 5. |
| 13 | Yang W, Laeyendecker O, Wendel SK, Zhang B, Sun S, Zhou J-Y, Ao M, Moore RD, Jackson JB, Zhang H: Glycoproteomic Study Reveals Altered Plasma Proteins Associated with HIV Elite Suppressors. Theranostics 2014, 4:1153. |
| 14 | Liu Y, Chen J, Sethi A, Li QK, Chen L, Collins B, Gillet LC, Wollscheid B, Zhang H, Aebersold R: Glycoproteomic analysis of prostate cancer tissues by SWATH mass spectrometry discovers N-acylethanolamine acid amidase and protein tyrosine kinase 7 as signatures for tumor aggressiveness. Molecular & Cellular Proteomics 2014, 13:1753-1768. |
| 16 | Deeb SJ, Cox J, Schmidt-Supprian M, Mann M: N-linked Glycosylation Enrichment for In-depth Cell Surface Proteomics of Diffuse Large B-cell Lymphoma Subtypes. Molecular & Cellular Proteomics 2014, 13:240-251. |
| 18 | Hirao Y, Matsuzaki H, Iwaki J, Kuno A, Kaji H, Ohkura T, Togayachi A, Abe M, Nomura M, Noguchi M, et al: Glycoproteomics Approach for Identifying Glycobiomarker Candidate Molecules for Tissue Type Classification of Non-small Cell Lung Carcinoma. Journal of Proteome Research 2014, 13:4705-4716. |
| 32 | Zhang Z, Sun Z, Zhu J, Liu J, Huang G, Ye M, Zou H: High-Throughput Determination of the Site-Specific N-Sialoglycan Occupancy Rates by Differential Oxidation of Glycoproteins Followed with Quantitative Glycoproteomics Analysis. Analytical Chemistry 2014, 86:9830-9837. |
| 33 | Zhu J, Sun Z, Cheng K, Chen R, Ye M, Xu B, Sun D, Wang L, Liu J, Wang F, Zou H: Comprehensive Mapping of Protein N-Glycosylation in Human Liver by Combining Hydrophilic Interaction Chromatography and Hydrazide Chemistry. Journal of Proteome Research 2014, 13:1713-1721. |
| 37 | Boersema PJ, Geiger T, Wisniewski JR, Mann M: Quantification of the N-glycosylated Secretome by Super-SILAC During Breast Cancer Progression and in Human Blood Samples. Molecular & Cellular Proteomics 2013, 12:158-171. |
| 38 | Kaji H, Ocho M, Togayachi A, Kuno A, Sogabe M, Ohkura T, Nozaki H, Angata T, Chiba Y, Ozaki H, et al: Glycoproteomic Discovery of Serological Biomarker Candidates for HCV/HBV Infection-Associated Liver Fibrosis and Hepatocellular Carcinoma. Journal of Proteome Research 2013, 12:2630-2640. |
| 40 | Li X, Jiang J, Zhao X, Wang J, Han H, Zhao Y, Peng B, Zhong R, Ying W, Qian X: N-glycoproteome Analysis of the Secretome of Human Metastatic Hepatocellular Carcinoma Cell Lines Combining Hydrazide Chemistry, HILIC Enrichment and Mass Spectrometry. Plos One 2013, 8. |
| 45 | Zhou H, Froehlich JW, Briscoe AC, Lee RS: The GlycoFilter: A Simple and Comprehensive Sample Preparation Platform for Proteomics, N-Glycomics and Glycosylation Site Assignment. Molecular & Cellular Proteomics 2013, 12:2981-2991. |
| 48 | Danzer C, Eckhardt K, Schmidt A, Fankhauser N, Ribrioux S, Wollscheid B, Mueller L, Schiess R, Zuellig R, Lehmann R, et al: Comprehensive Description of the N-Glycoproteome of Mouse Pancreatic beta-Cells and Human Islets. Journal of Proteome Research 2012, 11:1598-1608. |
| 52 | Yen T-Y, Macher BA, McDonald CA, Alleyne-Chin C, Timpe LC: Glycoprotein Profiles of Human Breast Cells Demonstrate a Clear Clustering of Normal/Benign versus Malignant Cell Lines and Basal versus Luminal Cell Lines. Journal of Proteome Research 2012, 11:656-667. |
| 62 | Arcinas A, Yen T-Y, Kebebew E, Macher BA: Cell Surface and Secreted Protein Profiles of Human Thyroid Cancer Cell Lines Reveal Distinct Glycoprotein Patterns. Journal of Proteome Research 2009, 8:3958-3968. |
| 64 | Chen R, Jiang X, Sun D, Han G, Wang F, Ye M, Wang L, Zou H: Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry. J Proteome Res 2009, 8:651-661. |