Detail


Protein	Talin-1
Gene	TLN1
Status	Reviewed
Source	Breast cancer xenografts; Liver; OVCAR-3 cell line (Ovarian cancer); Platelet
Years	2014-2015

Site	Identified Peptides	Year(Publication ID)
225	nGSHPVSFDK	2015(1);
225	DDILnGSHPVSFDK	2014(33); 2015(unpublished);
1534	nSTANLVK	2015(1);
1534	EVAnSTANLVK	2015(unpublished);2015(unpublished);
1571	AATAPLLEAVDnLSAFASNPEFSSIPAQISPEGR	2015(unpublished);

Sequence

1	11	21	31	41	51	61	71	81	91
MVALSLKISI	GNVVKTMQFE	PSTMVYDACR	IIRERIPEAP	AGPPSDFGLF	LSDDDPKKGI	WLEAGKALDY	YMLRNGDTME	YRKKQRPLKI	RMLDGTVKTI
101	111	121	131	141	151	161	171	181	191
MVDDSKTVTD	MLMTICARIG	ITNHDEYSLV	RELMEEKKEE	ITGTLRKDKT	LLRDEKKMEK	LKQKLHTDDE	LNWLDHGRTL	REQGVEEHET	LLLRRKFFYS
201	211	221	231	241	251	261	271	281	291
DQNVDSRDPV	QLNLLYVQAR	DDILNGSHPV	SFDKACEFAG	FQCQIQFGPH	NEQKHKAGFL	DLKDFLPKEY	VKQKGERKIF	QAHKNCGQMS	EIEAKVRYVK
301	311	321	331	341	351	361	371	381	391
LARSLKTYGV	SFFLVKEKMK	GKNKLVPRLL	GITKECVMRV	DEKTKEVIQE	WNLTNIKRWA	ASPKSFTLDF	GDYQDGYYSV	QTTEGEQIAQ	LIAGYIDIIL
401	411	421	431	441	451	461	471	481	491
KKKKSKDHFG	LEGDEESTML	EDSVSPKKST	VLQQQYNRVG	KVEHGSVALP	AIMRSGASGP	ENFQVGSMPP	AQQQITSGQM	HRGHMPPLTS	AQQALTGTIN
501	511	521	531	541	551	561	571	581	591
SSMQAVQAAQ	ATLDDFDTLP	PLGQDAASKA	WRKNKMDESK	HEIHSQVDAI	TAGTASVVNL	TAGDPAETDY	TAVGCAVTTI	SSNLTEMSRG	VKLLAALLED
601	611	621	631	641	651	661	671	681	691
EGGSGRPLLQ	AAKGLAGAVS	ELLRSAQPAS	AEPRQNLLQA	AGNVGQASGE	LLQQIGESDT	DPHFQDALMQ	LAKAVASAAA	ALVLKAKSVA	QRTEDSGLQT
701	711	721	731	741	751	761	771	781	791
QVIAAATQCA	LSTSQLVACT	KVVAPTISSP	VCQEQLVEAG	RLVAKAVEGC	VSASQAATED	GQLLRGVGAA	ATAVTQALNE	LLQHVKAHAT	GAGPAGRYDQ
801	811	821	831	841	851	861	871	881	891
ATDTILTVTE	NIFSSMGDAG	EMVRQARILA	QATSDLVNAI	KADAEGESDL	ENSRKLLSAA	KILADATAKM	VEAAKGAAAH	PDSEEQQQRL	REAAEGLRMA
901	911	921	931	941	951	961	971	981	991
TNAAAQNAIK	KKLVQRLEHA	AKQAAASATQ	TIAAAQHAAS	TPKASAGPQP	LLVQSCKAVA	EQIPLLVQGV	RGSQAQPDSP	SAQLALIAAS	QSFLQPGGKM
1001	1011	1021	1031	1041	1051	1061	1071	1081	1091
VAAAKASVPT	IQDQASAMQL	SQCAKNLGTA	LAELRTAAQK	AQEACGPLEM	DSALSVVQNL	EKDLQEVKAA	ARDGKLKPLP	GETMEKCTQD	LGNSTKAVSS
1101	1111	1121	1131	1141	1151	1161	1171	1181	1191
AIAQLLGEVA	QGNENYAGIA	ARDVAGGLRS	LAQAARGVAA	LTSDPAVQAI	VLDTASDVLD	KASSLIEEAK	KAAGHPGDPE	SQQRLAQVAK	AVTQALNRCV
1201	1211	1221	1231	1241	1251	1261	1271	1281	1291
SCLPGQRDVD	NALRAVGDAS	KRLLSDSLPP	STGTFQEAQS	RLNEAAAGLN	QAATELVQAS	RGTPQDLARA	SGRFGQDFST	FLEAGVEMAG	QAPSQEDRAQ
1301	1311	1321	1331	1341	1351	1361	1371	1381	1391
VVSNLKGISM	SSSKLLLAAK	ALSTDPAAPN	LKSQLAAAAR	AVTDSINQLI	TMCTQQAPGQ	KECDNALREL	ETVRELLENP	VQPINDMSYF	GCLDSVMENS
1401	1411	1421	1431	1441	1451	1461	1471	1481	1491
KVLGEAMTGI	SQNAKNGNLP	EFGDAISTAS	KALCGFTEAA	AQAAYLVGVS	DPNSQAGQQG	LVEPTQFARA	NQAIQMACQS	LGEPGCTQAQ	VLSAATIVAK
1501	1511	1521	1531	1541	1551	1561	1571	1581	1591
HTSALCNSCR	LASARTTNPT	AKRQFVQSAK	EVANSTANLV	KTIKALDGAF	TEENRAQCRA	ATAPLLEAVD	NLSAFASNPE	FSSIPAQISP	EGRAAMEPIV
1601	1611	1621	1631	1641	1651	1661	1671	1681	1691
ISAKTMLESA	GGLIQTARAL	AVNPRDPPSW	SVLAGHSRTV	SDSIKKLITS	MRDKAPGQLE	CETAIAALNS	CLRDLDQASL	AAVSQQLAPR	EGISQEALHT
1701	1711	1721	1731	1741	1751	1761	1771	1781	1791
QMLTAVQEIS	HLIEPLANAA	RAEASQLGHK	VSQMAQYFEP	LTLAAVGAAS	KTLSHPQQMA	LLDQTKTLAE	SALQLLYTAK	EAGGNPKQAA	HTQEALEEAV
1801	1811	1821	1831	1841	1851	1861	1871	1881	1891
QMMTEAVEDL	TTTLNEAASA	AGVVGGMVDS	ITQAINQLDE	GPMGEPEGSF	VDYQTTMVRT	AKAIAVTVQE	MVTKSNTSPE	ELGPLANQLT	SDYGRLASEA
1901	1911	1921	1931	1941	1951	1961	1971	1981	1991
KPAAVAAENE	EIGSHIKHRV	QELGHGCAAL	VTKAGALQCS	PSDAYTKKEL	IECARRVSEK	VSHVLAALQA	GNRGTQACIT	AASAVSGIIA	DLDTTIMFAT
2001	2011	2021	2031	2041	2051	2061	2071	2081	2091
AGTLNREGTE	TFADHREGIL	KTAKVLVEDT	KVLVQNAAGS	QEKLAQAAQS	SVATITRLAD	VVKLGAASLG	AEDPETQVVL	INAVKDVAKA	LGDLISATKA
2101	2111	2121	2131	2141	2151	2161	2171	2181	2191
AAGKVGDDPA	VWQLKNSAKV	MVTNVTSLLK	TVKAVEDEAT	KGTRALEATT	EHIRQELAVF	CSPEPPAKTS	TPEDFIRMTK	GITMATAKAV	AAGNSCRQED
2201	2211	2221	2231	2241	2251	2261	2271	2281	2291
VIATANLSRR	AIADMLRACK	EAAYHPEVAP	DVRLRALHYG	RECANGYLEL	LDHVLLTLQK	PSPELKQQLT	GHSKRVAGSV	TELIQAAEAM	KGTEWVDPED
2301	2311	2321	2331	2341	2351	2361	2371	2381	2391
PTVIAENELL	GAAAAIEAAA	KKLEQLKPRA	KPKEADESLN	FEEQILEAAK	SIAAATSALV	KAASAAQREL	VAQGKVGAIP	ANALDDGQWS	QGLISAARMV
2401	2411	2421	2431	2441	2451	2461	2471	2481	2491
AAATNNLCEA	ANAAVQGHAS	QEKLISSAKQ	VAASTAQLLV	ACKVKADQDS	EAMKRLQAAG	NAVKRASDNL	VKAAQKAAAF	EEQENETVVV	KEKMVGGIAQ
2501	2511	2521	2531	2541
IIAAQEEMLR	KERELEEARK	KLAQIRQQQY	KFLPSELRDE	H

UniProtKB-Q9Y490

Glycosites

Sequence

Reference

ID	Publication
1	Sun S, Shah P, Eshghi ST, Yang W, Trikannad N, Yang S, Chen L, Aiyetan P, Hoti N, Zhang Z, et al: Comprehensive analysis of protein glycosylation by solid-phase extraction of N-linked glycans and glycosite-containing peptides. Nat Biotech 2015, advance online publication.
33	Zhu J, Sun Z, Cheng K, Chen R, Ye M, Xu B, Sun D, Wang L, Liu J, Wang F, Zou H: Comprehensive Mapping of Protein N-Glycosylation in Human Liver by Combining Hydrophilic Interaction Chromatography and Hydrazide Chemistry. Journal of Proteome Research 2014, 13:1713-1721.