| Protein | Plexin-D1 |
| Gene | PLXND1 |
| Status | Reviewed |
| Source | Breast Cancer cell lines; Breast cancer xenografts; Colorectal tumor; DLBCL cell lines (Diffuse large B-cell lymphoma); HCC cell lines (Liver); HCC cell lines (Liver)Jurkat T cell line; HCCLM3 cell line (Liver); Hela cell line (cervical cancer); IGROV-1/CP cell line (Ovarian cancer)IGROV-1/CP; Jurkat T cell line; Liver; Lymphocytes; OVCAR-3 cell line (Ovarian cancer); Ovarian tumor; Plasma; Prostate; Prostate tumor; SKOV-3 cell line (Ovarian cancer); Serum; Urine; ovarian tumor |
| Years | 2005-2015 |
| Site | Identified Peptides | Year(Publication ID) |
|---|---|---|
| 155 | GnISAVAVR | 2014(33); 2015(unpublished);2015(unpublished); |
| 155 | RGnISAVAVR | 2005(81); 2013(40); 2014(16); 2015(unpublished); |
| 155 | RRGnISAVAVR | 2014(13); |
| 188 | NVAANHPnASTVGL | 2014(33); |
| 188 | nASTVGLVLPPAAGAGGSR | 2015(1); |
| 481 | APGLTSVAVASVNnYTAVFLGTVNGR | 2015(1); |
| 500 | INInESMQVVSR | 2014(16); 2014(32); |
| 500 | INLnESMQVVSR | 2005( 81); 2007(75); 2009(63); 2009(64); 2011(54); 2013(34); 2013(40); 2014(13); 2014(14); 2014(22); 2014(33); 2015(1); 2015(12); 2015(unpublished);2015(unpublished);2007(unpublished);2007(unpublished);2007;2007; |
| 500 | IIKINInESMQVV | 2013(37); |
| 583 | nSSQQHFWTSASEGPSR | 2015(1); |
| 583 | CTIQQDCTnSSQQHFWTSASEGPSR | 2014(16); |
| 583 | CTLQQDCTnSSQQHFWTSASEGPSR | 2013(45); |
| 696 | AnFTIYDCSR | 2007(40); 2013(13); 2014(16); 2014(33); 2014(12); 2015(unpublished);2015(unpublished);2015;2015;2015;2007;2007; |
| 696 | RNIVKAnFTIYDC | 2013(37); |
| 1017 | LQVLVnDTDPCTE | 2014(33); |
| 1099 | nVSMAVHHIGR | 2015(1); |
| 1099 | FHMVQnVSMAVH | 2014(33); |
| 1099 | FHMVQnVSMAVHHIGR | 2014(33); 2015(unpublished);2015(unpublished); |
| 1118 | VLnSTLITCPSPGALSNASAPVDFFINGR | 2015(1); 2015(12); |
| 1132 | VLNSTLITCPSPGALSnASAPVDFFINGR | 2015(1); 2015(12); |
| 1237 | IIHCSVnE | 2014(33); |
| 1341 | KGFAELQTDMTDLTKELnR | 2010(40); |
| 1 | 11 | 21 | 31 | 41 | 51 | 61 | 71 | 81 | 91 |
| MAPRAAGGAP | LSARAAAASP | PPFQTPPRCP | VPLLLLLLLG | AARAGALEIQ | RRFPSPTPTN | NFALDGAAGT | VYLAAVNRLY | QLSGANLSLE | AEAAVGPVPD |
| 101 | 111 | 121 | 131 | 141 | 151 | 161 | 171 | 181 | 191 |
| SPLCHAPQLP | QASCEHPRRL | TDNYNKILQL | DPGQGLVVVC | GSIYQGFCQL | RRRGNISAVA | VRFPPAAPPA | EPVTVFPSML | NVAANHPNAS | TVGLVLPPAA |
| 201 | 211 | 221 | 231 | 241 | 251 | 261 | 271 | 281 | 291 |
| GAGGSRLLVG | ATYTGYGSSF | FPRNRSLEDH | RFENTPEIAI | RSLDTRGDLA | KLFTFDLNPS | DDNILKIKQG | AKEQHKLGFV | SAFLHPSDPP | PGAQSYAYLA |
| 301 | 311 | 321 | 331 | 341 | 351 | 361 | 371 | 381 | 391 |
| LNSEARAGDK | ESQARSLLAR | ICLPHGAGGD | AKKLTESYIQ | LGLQCAGGAG | RGDLYSRLVS | VFPARERLFA | VFERPQGSPA | ARAAPAALCA | FRFADVRAAI |
| 401 | 411 | 421 | 431 | 441 | 451 | 461 | 471 | 481 | 491 |
| RAARTACFVE | PAPDVVAVLD | SVVQGTGPAC | ERKLNIQLQP | EQLDCGAAHL | QHPLSILQPL | KATPVFRAPG | LTSVAVASVN | NYTAVFLGTV | NGRLLKINLN |
| 501 | 511 | 521 | 531 | 541 | 551 | 561 | 571 | 581 | 591 |
| ESMQVVSRRV | VTVAYGEPVH | HVMQFDPADS | GYLYLMTSHQ | MARVKVAACN | VHSTCGDCVG | AADAYCGWCA | LETRCTLQQD | CTNSSQQHFW | TSASEGPSRC |
| 601 | 611 | 621 | 631 | 641 | 651 | 661 | 671 | 681 | 691 |
| PAMTVLPSEI | DVRQEYPGMI | LQISGSLPSL | SGMEMACDYG | NNIRTVARVP | GPAFGHQIAY | CNLLPRDQFP | PFPPNQDHVT | VEMSVRVNGR | NIVKANFTIY |
| 701 | 711 | 721 | 731 | 741 | 751 | 761 | 771 | 781 | 791 |
| DCSRTAQVYP | HTACTSCLSA | QWPCFWCSQQ | HSCVSNQSRC | EASPNPTSPQ | DCPRTLLSPL | APVPTGGSQN | ILVPLANTAF | FQGAALECSF | GLEEIFEAVW |
| 801 | 811 | 821 | 831 | 841 | 851 | 861 | 871 | 881 | 891 |
| VNESVVRCDQ | VVLHTTRKSQ | VFPLSLQLKG | RPARFLDSPE | PMTVMVYNCA | MGSPDCSQCL | GREDLGHLCM | WSDGCRLRGP | LQPMAGTCPA | PEIHAIEPLS |
| 901 | 911 | 921 | 931 | 941 | 951 | 961 | 971 | 981 | 991 |
| GPLDGGTLLT | IRGRNLGRRL | SDVAHGVWIG | GVACEPLPDR | YTVSEEIVCV | TGPAPGPLSG | VVTVNASKEG | KSRDRFSYVL | PLVHSLEPTM | GPKAGGTRIT |
| 1001 | 1011 | 1021 | 1031 | 1041 | 1051 | 1061 | 1071 | 1081 | 1091 |
| IHGNDLHVGS | ELQVLVNDTD | PCTELMRTDT | SIACTMPEGA | LPAPVPVCVR | FERRGCVHGN | LTFWYMQNPV | ITAISPRRSP | VSGGRTITVA | GERFHMVQNV |
| 1101 | 1111 | 1121 | 1131 | 1141 | 1151 | 1161 | 1171 | 1181 | 1191 |
| SMAVHHIGRE | PTLCKVLNST | LITCPSPGAL | SNASAPVDFF | INGRAYADEV | AVAEELLDPE | EAQRGSRFRL | DYLPNPQFST | AKREKWIKHH | PGEPLTLVIH |
| 1201 | 1211 | 1221 | 1231 | 1241 | 1251 | 1261 | 1271 | 1281 | 1291 |
| KEQDSLGLQS | HEYRVKIGQV | SCDIQIVSDR | IIHCSVNESL | GAAVGQLPIT | IQVGNFNQTI | ATLQLGGSET | AIIVSIVICS | VLLLLSVVAL | FVFCTKSRRA |
| 1301 | 1311 | 1321 | 1331 | 1341 | 1351 | 1361 | 1371 | 1381 | 1391 |
| ERYWQKTLLQ | MEEMESQIRE | EIRKGFAELQ | TDMTDLTKEL | NRSQGIPFLE | YKHFVTRTFF | PKCSSLYEER | YVLPSQTLNS | QGSSQAQETH | PLLGEWKIPE |
| 1401 | 1411 | 1421 | 1431 | 1441 | 1451 | 1461 | 1471 | 1481 | 1491 |
| SCRPNMEEGI | SLFSSLLNNK | HFLIVFVHAL | EQQKDFAVRD | RCSLASLLTI | ALHGKLEYYT | SIMKELLVDL | IDASAAKNPK | LMLRRTESVV | EKMLTNWMSI |
| 1501 | 1511 | 1521 | 1531 | 1541 | 1551 | 1561 | 1571 | 1581 | 1591 |
| CMYSCLRETV | GEPFFLLLCA | IKQQINKGSI | DAITGKARYT | LSEEWLLREN | IEAKPRNLNV | SFQGCGMDSL | SVRAMDTDTL | TQVKEKILEA | FCKNVPYSQW |
| 1601 | 1611 | 1621 | 1631 | 1641 | 1651 | 1661 | 1671 | 1681 | 1691 |
| PRAEDVDLEW | FASSTQSYIL | RDLDDTSVVE | DGRKKLNTLA | HYKIPEGASL | AMSLIDKKDN | TLGRVKDLDT | EKYFHLVLPT | DELAEPKKSH | RQSHRKKVLP |
| 1701 | 1711 | 1721 | 1731 | 1741 | 1751 | 1761 | 1771 | 1781 | 1791 |
| EIYLTRLLST | KGTLQKFLDD | LFKAILSIRE | DKPPLAVKYF | FDFLEEQAEK | RGISDPDTLH | IWKTNSLPLR | FWVNILKNPQ | FVFDIDKTDH | IDACLSVIAQ |
| 1801 | 1811 | 1821 | 1831 | 1841 | 1851 | 1861 | 1871 | 1881 | 1891 |
| AFIDACSISD | LQLGKDSPTN | KLLYAKEIPE | YRKIVQRYYK | QIQDMTPLSE | QEMNAHLAEE | SRKYQNEFNT | NVAMAEIYKY | AKRYRPQIMA | ALEANPTARR |
| 1901 | 1911 | 1921 | |||||||
| TQLQHKFEQV | VALMEDNIYE | CYSEA |
| ID | Publication |
|---|---|
| 1 | Sun S, Shah P, Eshghi ST, Yang W, Trikannad N, Yang S, Chen L, Aiyetan P, Hoti N, Zhang Z, et al: Comprehensive analysis of protein glycosylation by solid-phase extraction of N-linked glycans and glycosite-containing peptides. Nat Biotech 2015, advance online publication. |
| 12 | Weng Y, Sui Z, Jiang H, Shan Y, Chen L, Zhang S, Zhang L, Zhang Y: Releasing N-glycan from Peptide N-terminus by N-terminal Succinylation Assisted Enzymatic Deglycosylation. Scientific Reports 2015, 5. |
| 13 | Yang W, Laeyendecker O, Wendel SK, Zhang B, Sun S, Zhou J-Y, Ao M, Moore RD, Jackson JB, Zhang H: Glycoproteomic Study Reveals Altered Plasma Proteins Associated with HIV Elite Suppressors. Theranostics 2014, 4:1153. |
| 14 | Liu Y, Chen J, Sethi A, Li QK, Chen L, Collins B, Gillet LC, Wollscheid B, Zhang H, Aebersold R: Glycoproteomic analysis of prostate cancer tissues by SWATH mass spectrometry discovers N-acylethanolamine acid amidase and protein tyrosine kinase 7 as signatures for tumor aggressiveness. Molecular & Cellular Proteomics 2014, 13:1753-1768. |
| 16 | Deeb SJ, Cox J, Schmidt-Supprian M, Mann M: N-linked Glycosylation Enrichment for In-depth Cell Surface Proteomics of Diffuse Large B-cell Lymphoma Subtypes. Molecular & Cellular Proteomics 2014, 13:240-251. |
| 22 | Nicastri A, Gaspari M, Sacco R, Elia L, Gabriele C, Romano R, Rizzuto A, Cuda G: N-Glycoprotein Analysis Discovers New Up-Regulated Glycoproteins in Colorectal Cancer Tissue. Journal of Proteome Research 2014, 13:4932-4941. |
| 32 | Zhang Z, Sun Z, Zhu J, Liu J, Huang G, Ye M, Zou H: High-Throughput Determination of the Site-Specific N-Sialoglycan Occupancy Rates by Differential Oxidation of Glycoproteins Followed with Quantitative Glycoproteomics Analysis. Analytical Chemistry 2014, 86:9830-9837. |
| 33 | Zhu J, Sun Z, Cheng K, Chen R, Ye M, Xu B, Sun D, Wang L, Liu J, Wang F, Zou H: Comprehensive Mapping of Protein N-Glycosylation in Human Liver by Combining Hydrophilic Interaction Chromatography and Hydrazide Chemistry. Journal of Proteome Research 2014, 13:1713-1721. |
| 34 | Sun S, Zhang B, Aiyetan P, Zhou J-Y, Shah P, Yang W, Levine DA, Zhang Z, Chan DW, Zhang H: Analysis of N-glycoproteins using Genomic N-glycosite Prediction. Journal of Proteome Research 2013, 12:5609-5615. |
| 37 | Boersema PJ, Geiger T, Wisniewski JR, Mann M: Quantification of the N-glycosylated Secretome by Super-SILAC During Breast Cancer Progression and in Human Blood Samples. Molecular & Cellular Proteomics 2013, 12:158-171. |
| 40 | Li X, Jiang J, Zhao X, Wang J, Han H, Zhao Y, Peng B, Zhong R, Ying W, Qian X: N-glycoproteome Analysis of the Secretome of Human Metastatic Hepatocellular Carcinoma Cell Lines Combining Hydrazide Chemistry, HILIC Enrichment and Mass Spectrometry. Plos One 2013, 8. |
| 45 | Zhou H, Froehlich JW, Briscoe AC, Lee RS: The GlycoFilter: A Simple and Comprehensive Sample Preparation Platform for Proteomics, N-Glycomics and Glycosylation Site Assignment. Molecular & Cellular Proteomics 2013, 12:2981-2991. |
| 54 | Tian Y, Yao Z, Roden R, Zhang H: Identification of glycoproteins associated with different histological subtypes of ovarian tumors using quantitative glycoproteomics. Proteomics 2011, 11:4677-4687. |
| 63 | Cao J, Shen C, Wang H, Shen H, Chen Y, Nie A, Yan G, Lu H, Liu Y, Yang P: Identification of N-Glycosylation Sites on Secreted Proteins of Human Hepatocellular Carcinoma Cells with a Complementary Proteomics Approach. Journal of Proteome Research 2009, 8:662-672. |
| 64 | Chen R, Jiang X, Sun D, Han G, Wang F, Ye M, Wang L, Zou H: Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry. J Proteome Res 2009, 8:651-661. |
| 75 | Sun B, Ranish JA, Utleg AG, White JT, Yan X, Lin B, Hood L: Shotgun glycopeptide capture approach coupled with mass Spectrometry for comprehensive glycoproteomics. Molecular & Cellular Proteomics 2007, 6:141-149. |
| 81 | Liu T, Qian WJ, Gritsenko MA, Camp DG, Monroe ME, Moore RJ, Smith RD: Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry. Journal of Proteome Research 2005, 4:2070-2080. |