Detail


Protein	Talin-2
Gene	TLN2
Status	Reviewed
Source	Breast cancer xenografts; Colorectal tumor; OVCAR-3 cell line (Ovarian cancer); Platelet
Years	2014-2015

Site	Identified Peptides	Year(Publication ID)
1309	EDQIQVIGNLKnISMASSK	2014(22);
1536	nSTANLVK	2015(1);
1536	EVAnSTANLVK	2015(unpublished);2015(unpublished);

Sequence

1	11	21	31	41	51	61	71	81	91
MVALSLKICV	RHCNVVKTMQ	FEPSTAVYDA	CRVIRERVPE	AQTGQASDYG	LFLSDEDPRK	GIWLEAGRTL	DYYMLRNGDI	LEYKKKQRPQ	KIRMLDGSVK
101	111	121	131	141	151	161	171	181	191
TVMVDDSKTV	GELLVTICSR	IGITNYEEYS	LIQETIEEKK	EEGTGTLKKD	RTLLRDERKM	EKLKAKLHTD	DDLNWLDHSR	TFREQGVDEN	ETLLLRRKFF
201	211	221	231	241	251	261	271	281	291
YSDQNVDSRD	PVQLNLLYVQ	ARDDILNGSH	PVSFEKACEF	GGFQAQIQFG	PHVEHKHKPG	FLDLKEFLPK	EYIKQRGAEK	RIFQEHKNCG	EMSEIEAKVK
301	311	321	331	341	351	361	371	381	391
YVKLARSLRT	YGVSFFLVKE	KMKGKNKLVP	RLLGITKDSV	MRVDEKTKEV	LQEWPLTTVK	RWAASPKSFT	LDFGEYQESY	YSVQTTEGEQ	ISQLIAGYID
401	411	421	431	441	451	461	471	481	491
IILKKKQSKD	RFGLEGDEES	TMLEESVSPK	KSTILQQQFN	RTGKAEHGSV	ALPAVMRSGS	SGPETFNVGS	MPSPQQQVMV	GQMHRGHMPP	LTSAQQALMG
501	511	521	531	541	551	561	571	581	591
TINTSMHAVQ	QAQDDLSELD	SLPPLGQDMA	SRVWVQNKVD	ESKHEIHSQV	DAITAGTASV	VNLTAGDPAD	TDYTAVGCAI	TTISSNLTEM	SKGVKLLAAL
601	611	621	631	641	651	661	671	681	691
MDDEVGSGED	LLRAARTLAG	AVSDLLKAVQ	PTSGEPRQTV	LTAAGSIGQA	SGDLLRQIGE	NETDERFQDV	LMSLAKAVAN	AAAMLVLKAK	NVAQVAEDTV
701	711	721	731	741	751	761	771	781	791
LQNRVIAAAT	QCALSTSQLV	ACAKVVSPTI	SSPVCQEQLI	EAGKLVDRSV	ENCVRACQAA	TTDSELLKQV	SAAASVVSQA	LHDLLQHVRQ	FASRGEPIGR
801	811	821	831	841	851	861	871	881	891
YDQATDTIMC	VTESIFSSMG	DAGEMVRQAR	VLAQATSDLV	NAMRSDAEAE	IDMENSKKLL	AAAKLLADST	ARMVEAAKGA	AANPENEDQQ	QRLREAAEGL
901	911	921	931	941	951	961	971	981	991
RVATNAAAQN	AIKKKIVNRL	EVAAKQAAAA	ATQTIAASQN	AAVSNKNPAA	QQQLVQSCKA	VADHIPQLVQ	GVRGSQAQAE	DLSAQLALII	SSQNFLQPGS
1001	1011	1021	1031	1041	1051	1061	1071	1081	1091
KMVSSAKAAV	PTVSDQAAAM	QLSQCAKNLA	TSLAELRTAS	QKAHEACGPM	EIDSALNTVQ	TLKNELQDAK	MAAVESQLKP	LPGETLEKCA	QDLGSTSKAV
1101	1111	1121	1131	1141	1151	1161	1171	1181	1191
GSSMAQLLTC	AAQGNEHYTG	VAARETAQAL	KTLAQAARGV	AASTTDPAAA	HAMLDSARDV	MEGSAMLIQE	AKQALIAPGD	AERQQRLAQV	AKAVSHSLNN
1201	1211	1221	1231	1241	1251	1261	1271	1281	1291
CVNCLPGQKD	VDVALKSIGE	SSKKLLVDSL	PPSTKPFQEA	QSELNQAAAD	LNQSAGEVVH	ATRGQSGELA	AASGKFSDDF	DEFLDAGIEM	AGQAQTKEDQ
1301	1311	1321	1331	1341	1351	1361	1371	1381	1391
IQVIGNLKNI	SMASSKLLLA	AKSLSVDPGA	PNAKNLLAAA	ARAVTESINQ	LITLCTQQAP	GQKECDNALR	ELETVKGMLD	NPNEPVSDLS	YFDCIESVME
1401	1411	1421	1431	1441	1451	1461	1471	1481	1491
NSKVLGESMA	GISQNAKTGD	LPAFGECVGI	ASKALCGLTE	AAAQAAYLVG	ISDPNSQAGH	QGLVDPIQFA	RANQAIQMAC	QNLVDPGSSP	SQVLSAATIV
1501	1511	1521	1531	1541	1551	1561	1571	1581	1591
AKHTSALCNA	CRIASSKTAN	PVAKRHFVQS	AKEVANSTAN	LVKTIKALDG	DFSEDNRNKC	RIATAPLIEA	VENLTAFASN	PEFVSIPAQI	SSEGSQAQEP
1601	1611	1621	1631	1641	1651	1661	1671	1681	1691
ILVSAKTMLE	SSSYLIRTAR	SLAINPKDPP	TWSVLAGHSH	TVSDSIKSLI	TSIRDKAPGQ	RECDYSIDGI	NRCIRDIEQA	SLAAVSQSLA	TRDDISVEAL
1701	1711	1721	1731	1741	1751	1761	1771	1781	1791
QEQLTSVVQE	IGHLIDPIAT	AARGEAAQLG	HKVTQLASYF	EPLILAAVGV	ASKILDHQQQ	MTVLDQTKTL	AESALQMLYA	AKEGGGNPKA	QHTHDAITEA
1801	1811	1821	1831	1841	1851	1861	1871	1881	1891
AQLMKEAVDD	IMVTLNEAAS	EVGLVGGMVD	AIAEAMSKLD	EGTPPEPKGT	FVDYQTTVVK	YSKAIAVTAQ	EMMTKSVTNP	EELGGLASQM	TSDYGHLAFQ
1901	1911	1921	1931	1941	1951	1961	1971	1981	1991
GQMAAATAEP	EEIGFQIRTR	VQDLGHGCIF	LVQKAGALQV	CPTDSYTKRE	LIECARAVTE	KVSLVLSALQ	AGNKGTQACI	TAATAVSGII	ADLDTTIMFA
2001	2011	2021	2031	2041	2051	2061	2071	2081	2091
TAGTLNAENS	ETFADHRENI	LKTAKALVED	TKLLVSGAAS	TPDKLAQAAQ	SSAATITQLA	EVVKLGAASL	GSDDPETQVV	LINAIKDVAK	ALSDLISATK
2101	2111	2121	2131	2141	2151	2161	2171	2181	2191
GAASKPVDDP	SMYQLKGAAK	VMVTNVTSLL	KTVKAVEDEA	TRGTRALEAT	IECIKQELTV	FQSKDVPEKT	SSPEESIRMT	KGITMATAKA	VAAGNSCRQE
2201	2211	2221	2231	2241	2251	2261	2271	2281	2291
DVIATANLSR	KAVSDMLTAC	KQASFHPDVS	DEVRTRALRF	GTECTLGYLD	LLEHVLVILQ	KPTPEFKQQL	AAFSKRVAGA	VTELIQAAEA	MKGTEWVDPE
2301	2311	2321	2331	2341	2351	2361	2371	2381	2391
DPTVIAETEL	LGAAASIEAA	AKKLEQLKPR	AKPKQADETL	DFEEQILEAA	KSIAAATSAL	VKSASAAQRE	LVAQGKVGSI	PANAADDGQW	SQGLISAARM
2401	2411	2421	2431	2441	2451	2461	2471	2481	2491
VAAATSSLCE	AANASVQGHA	SEEKLISSAK	QVAASTAQLL	VACKVKADQD	SEAMRRLQAA	GNAVKRASDN	LVRAAQKAAF	GKADDDDVVV	KTKFVGGIAQ
2501	2511	2521	2531	2541
IIAAQEEMLK	KERELEEARK	KLAQIRQQQY	KFLPTELRED	EG

UniProtKB-Q9Y4G6

Glycosites

Sequence

Reference

ID	Publication
1	Sun S, Shah P, Eshghi ST, Yang W, Trikannad N, Yang S, Chen L, Aiyetan P, Hoti N, Zhang Z, et al: Comprehensive analysis of protein glycosylation by solid-phase extraction of N-linked glycans and glycosite-containing peptides. Nat Biotech 2015, advance online publication.
22	Nicastri A, Gaspari M, Sacco R, Elia L, Gabriele C, Romano R, Rizzuto A, Cuda G: N-Glycoprotein Analysis Discovers New Up-Regulated Glycoproteins in Colorectal Cancer Tissue. Journal of Proteome Research 2014, 13:4932-4941.