Detail


Protein	Brefeldin A-inhibited guanine nucleotide-exchange protein 1
Gene	ARFGEF1
Status	Reviewed
Source	Liver; OVCAR-3 cell line (Ovarian cancer)
Years	2014-2015

Site	Identified Peptides	Year(Publication ID)
398	LSVSSnDTQESGNSSGPSPGAK	2014(33);
398	TPSLPDDRLSVSSnDTQESGNSSGPSPGAKF	2014(33);
405	nSSGPSPGAK	2015(1);
405	LSVSSNDTQESGnSSGPSPGAK	2014(33);
405	TPSLPDDRLSVSSNDTQESGnSSGPSPGAKF	2014(33);

Sequence

1	11	21	31	41	51	61	71	81	91
MYEGKKTKNM	FLTRALEKIL	ADKEVKKAHH	SQLRKACEVA	LEEIKAETEK	QSPPHGEAKA	GSSTLPPVKS	KTNFIEADKY	FLPFELACQS	KCPRIVSTSL
101	111	121	131	141	151	161	171	181	191
DCLQKLIAYG	HLTGNAPDST	TPGKKLIDRI	IETICGCFQG	PQTDEGVQLQ	IIKALLTAVT	SQHIEIHEGT	VLQAVRTCYN	IYLASKNLIN	QTTAKATLTQ
201	211	221	231	241	251	261	271	281	291
MLNVIFARME	NQALQEAKQM	EKERHRQHHH	LLQSPVSHHE	PESPQLRYLP	PQTVDHISQE	HEGDLDLHTN	DVDKSLQDDT	EPENGSDISS	AENEQTEADQ
301	311	321	331	341	351	361	371	381	391
ATAAETLSKN	EVLYDGENHD	CEEKPQDIVQ	NIVEEMVNIV	VGDMGEGTTI	NASADGNIGT	IEDGSDSENI	QANGIPGTPI	SVAYTPSLPD	DRLSVSSNDT
401	411	421	431	441	451	461	471	481	491
QESGNSSGPS	PGAKFSHILQ	KDAFLVFRSL	CKLSMKPLSD	GPPDPKSHEL	RSKILSLQLL	LSILQNAGPI	FRTNEMFINA	IKQYLCVALS	KNGVSSVPEV
501	511	521	531	541	551	561	571	581	591
FELSLSIFLT	LLSNFKTHLK	MQIEVFFKEI	FLYILETSTS	SFDHKWMVIQ	TLTRICADAQ	SVVDIYVNYD	CDLNAANIFE	RLVNDLSKIA	QGRGSQELGM
601	611	621	631	641	651	661	671	681	691
SNVQELSLRK	KGLECLVSIL	KCMVEWSKDQ	YVNPNSQTTL	GQEKPSEQEM	SEIKHPETIN	RYGSLNSLES	TSSSGIGSYS	TQMSGTDNPE	QFEVLKQQKE
701	711	721	731	741	751	761	771	781	791
IIEQGIDLFN	KKPKRGIQYL	QEQGMLGTTP	EDIAQFLHQE	ERLDSTQVGE	FLGDNDKFNK	EVMYAYVDQH	DFSGKDFVSA	LRMFLEGFRL	PGEAQKIDRL
801	811	821	831	841	851	861	871	881	891
MEKFAARYLE	CNQGQTLFAS	ADTAYVLAYS	IIMLTTDLHS	PQVKNKMTKE	QYIKMNRGIN	DSKDLPEEYL	SAIYNEIAGK	KISMKETKEL	TIPTKSSKQN
901	911	921	931	941	951	961	971	981	991
VASEKQRRLL	YNLEMEQMAK	TAKALMEAVS	HVQAPFTSAT	HLEHVRPMFK	LAWTPFLAAF	SVGLQDCDDT	EVASLCLEGI	RCAIRIACIF	SIQLERDAYV
1001	1011	1021	1031	1041	1051	1061	1071	1081	1091
QALARFTLLT	VSSGITEMKQ	KNIDTIKTLI	TVAHTDGNYL	GNSWHEILKC	ISQLELAQLI	GTGVKPRYIS	GTVRGREGSL	TGTKDQAPDE	FVGLGLVGGN
1101	1111	1121	1131	1141	1151	1161	1171	1181	1191
VDWKQIASIQ	ESIGETSSQS	VVVAVDRIFT	GSTRLDGNAI	VDFVRWLCAV	SMDELLSTTH	PRMFSLQKIV	EISYYNMGRI	RLQWSRIWEV	IGDHFNKVGC
1201	1211	1221	1231	1241	1251	1261	1271	1281	1291
NPNEDVAIFA	VDSLRQLSMK	FLEKGELANF	RFQKDFLRPF	EHIMKRNRSP	TIRDMVVRCI	AQMVNSQAAN	IRSGWKNIFS	VFHLAASDQD	ESIVELAFQT
1301	1311	1321	1331	1341	1351	1361	1371	1381	1391
TGHIVTLVFE	KHFPATIDSF	QDAVKCLSEF	ACNAAFPDTS	MEAIRLIRHC	AKYVSDRPQA	FKEYTSDDMN	VAPEDRVWVR	GWFPILFELS	CIINRCKLDV
1401	1411	1421	1431	1441	1451	1461	1471	1481	1491
RTRGLTVMFE	IMKTYGHTYE	KHWWQDLFRI	VFRIFDNMKL	PEQQTEKAEW	MTTTCNHALY	AICDVFTQYL	EVLSDVLLDD	IFAQLYWCVQ	QDNEQLARSG
1501	1511	1521	1531	1541	1551	1561	1571	1581	1591
TNCLENVVIL	NGEKFTLEIW	DKTCNCTLDI	FKTTIPHALL	TWRPNSGETA	PPPPSPVSEK	PLDTISQKSV	DIHDSIQPRS	VDNRPQAPLV	SASAVNEEVS
1601	1611	1621	1631	1641	1651	1661	1671	1681	1691
KIKSTAKFPE	QKLFAALLIK	CVVQLELIQT	IDNIVFFPAT	SKKEDAENLA	AAQRDAVDFD	VRVDTQDQGM	YRFLTSQQLF	KLLDCLLESH	RFAKAFNSNN
1701	1711	1721	1731	1741	1751	1761	1771	1781	1791
EQRTALWKAG	FKGKSKPNLL	KQETSSLACG	LRILFRMYMD	ESRVSAWEEV	QQRLLNVCSE	ALSYFLTLTS	ESHREAWTNL	LLLFLTKVLK	ISDNRFKAHA
1801	1811	1821	1831	1841
SFYYPLLCEI	MQFDLIPELR	AVLRRFFLRI	GVVFQISQPP	EQELGINKQ

Reference

ID	Publication
1	Sun S, Shah P, Eshghi ST, Yang W, Trikannad N, Yang S, Chen L, Aiyetan P, Hoti N, Zhang Z, et al: Comprehensive analysis of protein glycosylation by solid-phase extraction of N-linked glycans and glycosite-containing peptides. Nat Biotech 2015, advance online publication.
33	Zhu J, Sun Z, Cheng K, Chen R, Ye M, Xu B, Sun D, Wang L, Liu J, Wang F, Zou H: Comprehensive Mapping of Protein N-Glycosylation in Human Liver by Combining Hydrophilic Interaction Chromatography and Hydrazide Chemistry. Journal of Proteome Research 2014, 13:1713-1721.

UniProtKB-Q9Y6D6

Glycosites

Sequence

Reference