Detail

Contains

UniProtKB-Q9Y6L7


Protein	Tolloid-like protein 2
Gene	TLL2
Status	Reviewed
Source	LNCap/PC3 cell lines (Prostate cancer); OVCAR-3 cell line (Ovarian cancer); Ovarian tumor; Pancreatic islets; Prostate tumor
Years	2007-2015

Glycosites

Site	Identified Peptides	Year(Publication ID)
126	EnTTLLHSPGTLHAAAK	2015(2);
171	IGGnFTGSQR	2012(48);
171	VIGGnFTGSQR	2012(48); 2015(unpublished);2007(unpublished);2007;
805	nISSTAGHR	2015(1);

Sequence

1	11	21	31	41	51	61	71	81	91
MPRATALGAL	VSLLLLLPLP	RGAGGLGERP	DATADYSELD	GEEGTEQQLE	HYHDPCKAAV	FWGDIALDED	DLKLFHIDKA	RDWTKQTVGA	TGHSTGGLEE
101	111	121	131	141	151	161	171	181	191
QASESSPDTT	AMDTGTKEAG	KDGRENTTLL	HSPGTLHAAA	KTFSPRVRRA	TTSRTERIWP	GGVIPYVIGG	NFTGSQRAIF	KQAMRHWEKH	TCVTFIERTD
201	211	221	231	241	251	261	271	281	291
EESFIVFSYR	TCGCCSYVGR	RGGGPQAISI	GKNCDKFGIV	AHELGHVVGF	WHEHTRPDRD	QHVTIIRENI	QPGQEYNFLK	MEAGEVSSLG	ETYDFDSIMH
301	311	321	331	341	351	361	371	381	391
YARNTFSRGV	FLDTILPRQD	DNGVRPTIGQ	RVRLSQGDIA	QARKLYKCPA	CGETLQDTTG	NFSAPGFPNG	YPSYSHCVWR	ISVTPGEKIV	LNFTSMDLFK
401	411	421	431	441	451	461	471	481	491
SRLCWYDYVE	VRDGYWRKAP	LLGRFCGDKI	PEPLVSTDSR	LWVEFRSSSN	ILGKGFFAAY	EATCGGDMNK	DAGQIQSPNY	PDDYRPSKEC	VWRITVSEGF
501	511	521	531	541	551	561	571	581	591
HVGLTFQAFE	IERHDSCAYD	YLEVRDGPTE	ESALIGHFCG	YEKPEDVKSS	SNRLWMKFVS	DGSINKAGFA	ANFFKEVDEC	SWPDHGGCEH	RCVNTLGSYK
601	611	621	631	641	651	661	671	681	691
CACDPGYELA	ADKKMCEVAC	GGFITKLNGT	ITSPGWPKEY	PTNKNCVWQV	VAPAQYRISL	QFEVFELEGN	DVCKYDFVEV	RSGLSPDAKL	HGRFCGSETP
701	711	721	731	741	751	761	771	781	791
EVITSQSNNM	RVEFKSDNTV	SKRGFRAHFF	SDKDECAKDN	GGCQHECVNT	FGSYLCRCRN	GYWLHENGHD	CKEAGCAHKI	SSVEGTLASP	NWPDKYPSRR
801	811	821	831	841	851	861	871	881	891
ECTWNISSTA	GHRVKLTFNE	FEIEQHQECA	YDHLEMYDGP	DSLAPILGRF	CGSKKPDPTV	ASGSSMFLRF	YSDASVQRKG	FQAVHSTECG	GRLKAEVQTK
901	911	921	931	941	951	961	971	981	991
ELYSHAQFGD	NNYPSEARCD	WVIVAEDGYG	VELTFRTFEV	EEEADCGYDY	MEAYDGYDSS	APRLGRFCGS	GPLEEIYSAG	DSLMIRFRTD	DTINKKGFHA
1001	1011
RYTSTKFQDA	LHMKK

Reference

ID	Publication
1	Sun S, Shah P, Eshghi ST, Yang W, Trikannad N, Yang S, Chen L, Aiyetan P, Hoti N, Zhang Z, et al: Comprehensive analysis of protein glycosylation by solid-phase extraction of N-linked glycans and glycosite-containing peptides. Nat Biotech 2015, advance online publication.
2	Shah P, Wang X, Yang W, Eshghi ST, Sun S, Hoti N, Chen L, Yang S, Pasay J, Rubin A: Integrated Proteomic and Glycoproteomic Analyses of Prostate Cancer Cells Reveal Glycoprotein Alteration in Protein Abundance and Glycosylation. Molecular & Cellular Proteomics 2015, 14:2753-2763.
48	Danzer C, Eckhardt K, Schmidt A, Fankhauser N, Ribrioux S, Wollscheid B, Mueller L, Schiess R, Zuellig R, Lehmann R, et al: Comprehensive Description of the N-Glycoproteome of Mouse Pancreatic beta-Cells and Human Islets. Journal of Proteome Research 2012, 11:1598-1608.