Detail

UniProtKB-V5YQU3


Protein	Receptor protein-tyrosine kinase
Gene	FGFR2-BICC1
Status	Unreviewed
Source	Breast Cancer cell lines; Breast cancer xenografts; Liver; OVCAR-3 cell line (Ovarian cancer)
Years	2013-2015

Glycosites

Site	Identified Peptides	Year(Publication ID)
229	HSGInSSNAEVLALFNVTEADAGEYICK	2015(1);
240	nVTEADAGEYICK	2015(1);
240	HSGINSSNAEVLALFnVTEADAGEYICK	2015(1);
261	nQSAWLTVLPK	2015(1);
261	NYIGQAnQSAWIT	2013(37);
261	VSNYIGQAnQSAWLTVLPK	2014(33); 2015(1); 2015(unpublished);

Sequence

1	11	21	31	41	51	61	71	81	91
MVSWGRFICL	VVVTMATLSL	ARPSFSLVED	TTLEPEDAIS	SGDDEDDTDG	AEDFVSENSN	NKRAPYWTNT	EKMEKRLHAV	PAANTVKFRC	PAGGNPMPTM
101	111	121	131	141	151	161	171	181	191
RWLKNGKEFK	QEHRIGGYKV	RNQHWSLIME	SVVPSDKGNY	TCVVENEYGS	INHTYHLDVV	ERSPHRPILQ	AGLPANASTV	VGGDVEFVCK	VYSDAQPHIQ
201	211	221	231	241	251	261	271	281	291
WIKHVEKNGS	KYGPDGLPYL	KVLKHSGINS	SNAEVLALFN	VTEADAGEYI	CKVSNYIGQA	NQSAWLTVLP	KQQAPGREKE	ITASPDYLEI	AIYCIGVFLI
301	311	321	331	341	351	361	371	381	391
ACMVVTVILC	RMKNTTKKPD	FSSQPAVHKL	TKRIPLRRQV	TVSAESSSSM	NSNTPLVRIT	TRLSSTADTP	MLAGVSEYEL	PEDPKWEFPR	DKLTLGKPLG
401	411	421	431	441	451	461	471	481	491
EGCFGQVVMA	EAVGIDKDKP	KEAVTVAVKM	LKDDATEKDL	SDLVSEMEMM	KMIGKHKNII	NLLGACTQDG	PLYVIVEYAS	KGNLREYLRA	RRPPGMEYSY
501	511	521	531	541	551	561	571	581	591
DINRVPEEQM	TFKDLVSCTY	QLARGMEYLA	SQKCIHRDLA	ARNVLVTENN	VMKIADFGLA	RDINNIDYYK	KTTNGRLPVK	WMAPEALFDR	VYTHQSDVWS
601	611	621	631	641	651	661	671	681	691
FGVLMWEIFT	LGGSPYPGIP	VEELFKLLKE	GHRMDKPANC	TNELYMMMRD	CWHAVPSQRP	TFKQLVEDLD	RILTLTTNEI	MEETNTQIAW	PSKLKIGAKS
701	711	721	731	741	751	761	771	781	791
KKDPHIKVSG	KKEDVKEAKE	MIMSVLDTKS	NRVTLKMDVS	HTEHSHVIGK	GGNNIKKVME	ETGCHIHFPD	SNRNNQAEKS	NQVSIAGQPA	GVESARVRIR
801	811	821	831	841	851	861	871	881	891
ELLPLVLMFE	LPIAGILQPV	PDPNSPSIQH	ISQTYNISVS	FKQRSRMYGA	TVIVRGSQNN	TSAVKEGTAM	LLEHLAGSLA	SAIPVSTQLD	IAAQHHLFMM
901	911	921	931	941	951	961	971	981	991
GRNGSNIKHI	MQRTGAQIHF	PDPSNPQKKS	TVYLQGTIES	VCLARQYLMG	CLPLVLMFDM	KEEIEVDPQF	IAQLMEQLDV	FISIKPKPKQ	PSKSVIVKSV
1001	1011	1021	1031	1041	1051	1061	1071	1081	1091
ERNALNMYEA	RKCLLGLESS	GVTIATSPSP	ASCPAGLACP	SLDILASAGL	GLTGLGLLGP	TTLSLNTSTT	PNSLLNALNS	SVSPLQSPSS	GTPSPTLWAP
1101	1111	1121	1131	1141	1151	1161	1171	1181	1191
PLANTSSATG	FSAIPHLMIP	STAQATLTNI	LLSGVPTYGH	TAPSPPPGLT	PVDVHINSMQ	TEGKKISAAL	NGHAQSPDIK	YGAISTSSLG	EKVLSANHGD
1201	1211	1221	1231	1241	1251	1261	1271	1281	1291
PSIQTSGSEQ	TSPKSSPTEG	CNDAFVEVGM	PRSPSHSGNA	GDLKQMMCPS	KVSCAKRQTV	ELLQGTKNSH	LHSTDRLLSD	PELSATESPL	ADKKAPGSER
1301	1311	1321	1331	1341	1351	1361	1371	1381	1391
AAERAAAAQQ	NSERAHLAPR	SSYVNMQAFD	YEQKKLLATK	AMLKKPVVTE	VRTPTNTWSG	LGFSKSMPAE	TIKELRRANH	VSYKPTMTTT	YEGSSMSLSR
1401	1411	1421	1431	1441	1451	1461	1471	1481	1491
SNSREHLGGG	SESDNWRDRN	GIGPGSHSEF	AASIGSPKRK	QNKSTEHYLS	SSNYMDCISS	LTGSNGCNLN	SSFKGSDLPE	LFSKLGLGKY	TDVFQQQEID
1501	1511	1521	1531	1541	1551	1561	1571
LQTFLTLTDQ	DLKELGITTF	GARRKMLLAI	SELNKNRRKL	FESPNARTSF	LEGGASGRLP	RQYHSDIASV	SGRW

Reference

ID	Publication
1	Sun S, Shah P, Eshghi ST, Yang W, Trikannad N, Yang S, Chen L, Aiyetan P, Hoti N, Zhang Z, et al: Comprehensive analysis of protein glycosylation by solid-phase extraction of N-linked glycans and glycosite-containing peptides. Nat Biotech 2015, advance online publication.
33	Zhu J, Sun Z, Cheng K, Chen R, Ye M, Xu B, Sun D, Wang L, Liu J, Wang F, Zou H: Comprehensive Mapping of Protein N-Glycosylation in Human Liver by Combining Hydrophilic Interaction Chromatography and Hydrazide Chemistry. Journal of Proteome Research 2014, 13:1713-1721.
37	Boersema PJ, Geiger T, Wisniewski JR, Mann M: Quantification of the N-glycosylated Secretome by Super-SILAC During Breast Cancer Progression and in Human Blood Samples. Molecular & Cellular Proteomics 2013, 12:158-171.